RESUMO
Solutions of the ferrous sulfate, of the albumin and of the suspension of liposomes were irradiated by mixed gamma-neutron radiation (fission spectrum neutrons, contribution of gamma-component to the absorbed dose up to 20%) at the pulse reactor BARS-6 with single-pulse (duration 100 micros) or continuous radiation (duration 60 min). It was shown, that after the pulse irradiation the concentration of the malonic dialdehyde in liposomes was in 3-4 times higher than after the continuous radiation at equal absorbed doses (p < 0.05). On the contrary, the irradiation of the liposomes suspension as well as of the solutions of the ferrous sulfate and of the albumin in a mode of single-pulse or of continuous mode did not reveal the statistically significant differences in the production of Fe3+ ions and of peroxides of the albumin for two mode of the radiation action.
Assuntos
Albuminas/química , Compostos Ferrosos/química , Raios gama , Lipossomos , Nêutrons , Relação Dose-Resposta à Radiação , SoluçõesRESUMO
Accumulation and excretion of beta-carotene in rat liver tissue were studied when the carotinoid was intraperitoneally administered as olive oil as suspension and a water liposomal suspension. Single injection of the liposomal form of beta-carotene caused an increase in its content in liver tissue. If beta-carotene was administered at a dose of 10 mg/kg its maximal content 44 mg/g of the tissue was observed within one day, and at a dose of 50 mg/kg, its maximal content constituted 178 mg/g within two days. Administration of beta-carotene as an oil suspension at a dose of 50 mg/kg led to a considerably slight accumulation in rat liver tissue with the maximal value of 12 mg/kg of the tissue within two days. Possible use of beta-carotene various forms, as well as experimental models for study their biological activity are discussed.