Additivity of retention of diastereoisomeric and enantiomeric arylphthalides, aryl(arylene)phthalides and aryldiphthalides of dyadic and triadic composition.

For the first time, four series of new phthalide-containing heteroaromatic compounds were separated by reverse phase HPLC: OYO, OYS, SYS; OYOYO, OYOYS, SYOYS; SYSYS, SYSYO, OYSYO; OYYO, OYYS, SYYS, (where O - diphenyloxide, S - diphenylsulfide, Y - phthalide group). A fundamental difference was established in the chromatographic behavior of diaryl(arylene)diphthalides, built on the principle of "head-to-tail", and diaryldiphthalides with a structure of "head-to-head". The meso and chiral diastereoisomers of the former were eluted by one peak, while the latter existed in solution in the forms of stable cis (racemic form) and trans (meso form) rotamers with different retention times. It was shown that to calculate the retention times of related diarylphthalides, diaryl(arylene)phthalides, diastereoisomeric and enantiomeric diaryldiphthalides of an asymmetric structure, the half-sum rule can be applied according to which: tR(A-X-B)≈[(tR(A-X-A)+tR(B-X-B)]/2. For diaryl(arylene)diphthalides of a triadic structure, a modified additive scheme for calculating retention times is proposed, including multiplication and division operations: tR(A-A-A) = tR(A-A-B) × tR(A-B-B)/tR(B-B-B).

Use of lectins as indicators for magnetic field action on erythrocyte membranes.

The effects of magnetic fields on biological membranes in general and on the red blood cell membrane in particular have been studied intensively in the last two decades. A variety of methods for evaluation of magnetic field action on the structure and function of biological membranes has been used. It has been suggested /1/ that the cell membrane can be considered as one of the primary targets affected by magnetic field exposure.

[Intraoperative echocardiography]. / Intraoperatsionnaia ékhokardiografiia.

Combined echocardiography (uni- and two-dimensional, and Doppler) was used during surgery on an open heart. Technological aspects of such examinations are discussed. A method for tricuspid valve annuloplasty is suggested, monitored and regulated by echocardiography on an open heart. Such monitoring will help assess the efficacy of valve-preserving surgery.

[Results of the plastic repair of interventricular septal defects 15 to 20 years after operation]. / Rezul'taty plastiki defektov mezhzheludochkovoi peregorodki cherez 15-20 let posle operatsii.

The authors carried out a comprehensive examination of patients operated on for the radical correction of a ventricular septum defect through the right atrium and with a temporary excision of the septal cusp of the tricuspid valev. The ECG, PCG, and roentgenogram were found to be altered at a long-term period. Examination of the tricuspid valve showed its good function at a long-term period. Practical recommendations on examining this group of patients are offered.

[Evaluation of the contractile function of the right ventricle of the heart after plastic procedures on the tricuspid valve during artificial circulation]. / Otsenka sokratitel'noi funktsii pravogo zheludochka serdtsa posle plasticheskikh vmeshatel'stv na trikuspidal'nom klapane v usloviiakh iskusstvennogo krovoobrashcheniia.

Changes in right-ventricular function were investigated after surgical correction of the mitral-tricuspid valvular defect and congenital heart diseases, such as the interventricular septum defect and Fallot's tetrad. In patients with acquired valvular defects, the analysis of intraventricular pressure curves showed reduced hyperfunction and better relaxation of the right ventricle. The assessment of the effects of different surgical accesses used in radical correction of the interventricular septum defect and Fallot's tetrad demonstrated the advantage of sparing surgery achieved through the right atrium.