[The patterns of alteration of content of growth-stimulating and growth-inhibiting factors in blood serum under ß-cell chronic lymphatic leukemia and their diagnostic value.]

The article evaluates balance of growth-stimulating and growth-inhibiting factors in blood serum of patients with different stages of B-cell chronic lymphatic leukemia residing on examination and hospital treatment in Saratov clinic of occupational pathology and hematology in 2007-2016. The indices of content of VEGF165, PDGF-AB, pRb, p53 and p73 in blood serum was detected using solid-phase enzyme-linked immunosorbent assay. The specific characteristic of B-cell chronic lymphatic leukemia became stably higher content of growth-stimulating cytokines of development of disease that permitted to conclude about (VEGF165, PDGF-AB) in dynamics of development of disease that permitted to conclude about their important role in mechanisms of oncogene transformation and stimulation of proliferation activity of neoplastic cells at various stages of pathology. At the same time, disturbance of anti-proliferation signals under B-cell chronic lymphatic leukemia was characterized by singleat-once decreasing of controlling cell cycle of several mechanisms of regulation of changing G1-phase to S-phase conditioned by low level of inhibitors of cyclin-dependent kinases (p53 and p73) and inadequate expression of regulator of cellular cycle of protein pRb.

[Chancriform pyoderma]. / Shankriformnaia piodermiia.

A patient with chancriform pyoderma is described. He has been repeatedly examined with the use of routine serologic tests, Treponema pallidum immobilization and immunofluorescence tests and other laboratory analyses; this has permitted a correct clinical diagnosis. A 6-month follow-up, including clinical examinations and laboratory analyses, has confirmed the diagnosis.

[Formation of structures of the cochlear complex, olfactory bulbs, and cerebellum during postnatal development of rats]. / Formirovanie struktur kokhlearnogo kompleksa, oboniatel'nykh lukovits i mozzhechka v postnatal'nom razvitii krys.

Formation of structures in the cochlear complex, olfactory bulb and cerebellum has been studied during postnatal development, with special reference to the development of granular cells in the structures mentioned. The granular cells have been demonstrated to be formed rather synchronously and according to a common plan By the time of birth, every structure has a layer of the granular cells formed which is cambial for most of the granular cells in the given structure. It has bene found out that in the cochlear complex, by the time of birth, there is an external layer of the granular cells which is analogous to the external cerebellar granular layer and is connected with it by a cellular cord. Morphological changes in the structure of the granular cells have been described in the process of their differentiation.

[Disruption of food-getting movements after removal of the motor or premotor zone of the cerebral cortex in cats]. / Narusheniia pishchedobyvatel'nykh dvizhenii posle udaleniia motornoi ili premotornoi oblasti kory bol'shogo mozga u koshek.

Instrumental food-procuring movements were studied in cats before and after unilateral or bilateral ablation of the motor or premotor cortical area. It is shown that unilateral impairment of the motor area affects the strength and accuracy of movements of the contralateral fore-leg, whereas the ablation of the premotor area leads to a slowing down of movements and breaking of a goal-directed movement into separate components. Bilataral ablation of the motor area irreversibly abolished the instrumental reflex. The ablation of the premotor cortex destroyed the animal's reaction to the sound signal, but food-procuring movements of the fore-legs were disturbed only temporarily. The obtained data are discussed on the basis of the concept that in cats the above cortical areas play different roles in the organization of goal directed behaviour.

[Granular neurons of the cochlear complex in rats]. / Izuchenie zernistykh kletok kokhlearnogo kompleksa krysy.

In the cochlear complex of white male rats the dorsal nucleus, the anterior ventral nucleus, the posterior ventral nucleus and the granular layer were studied histologically and morphometrically. While counting the number of different cells in all the above mentioned formations, by means of ocular grid (S.B. Stefanov, 1974) it was revealed that the granular neurons of the cochlear nuclei of the rats form 72--86 per cent of all the cells. The granular cells represent an independent type of neurons and these differ clearly from other neurons by the diameter of their nuclei and by the size of the pericarion. The granular cells form two cell types according to patterns of their nuclei, and these cell types are independent of each other within the limits of every cochlear complex. Percentage of different types of neurons in different parts of cochlear nuclei depends on the cell density. The distribution of the granular neurons is independent on that of large and middle size neurons.

[A cytophotometric and karyometric study of the granular cells of the rat brain. I. Granular cells of the cochlear complex and cerebellum]. / Tsitofotometricheskoe i kariometricheskoe issledovanie zernistykh kletok mozga krysy. I. Zernistye kletki kokhlearnogo kompleksa i mozzhechka

Two cell types can be distinguished in granular cells of the chochlear complex of the rat by the form of their processes and the structure of the nuclear chromatin. It is shown cytophotometrically that the majority of the granular cells of the cochlear complex and in the cerebellar cortex are diploid. However, some cells contain DNA amount close to tetraploid. Some correlation between the size of the nucleus and its DNA amount was discovered both in the cerebellar cortex and in the cochlear complex.