RESUMO
We report mid-aortic syndrome (MAC) in two preterm infants. Both infants developed malignant hypertension refractory to medical therapy and died early in infancy. Thus far, this account is of the two youngest patients with MAC.
Assuntos
Anormalidades Múltiplas/diagnóstico , Aorta Abdominal/anormalidades , Aorta Torácica/anormalidades , Cardiopatias Congênitas/diagnóstico , Hipertensão Renal/diagnóstico , Recém-Nascido Prematuro , Anormalidades Múltiplas/terapia , Cesárea , Constrição Patológica , Progressão da Doença , Ecocardiografia Doppler , Evolução Fatal , Feminino , Idade Gestacional , Cardiopatias Congênitas/terapia , Humanos , Hipertensão Renal/terapia , Recém-Nascido , Masculino , Cuidados Paliativos/métodos , Gravidez , Síndrome , Tomografia Computadorizada por Raios X/métodos , Ultrassonografia Pré-NatalRESUMO
OBJECTIVE: To quantify spectral power in frequency specific bands and commonly observed types of bursting activities in the EEG during early human development. METHODS: An extensive archive of EEG data from human infants from 35 to 52 weeks postmenstrual age obtained in a prior multi-center study was analyzed using power spectrum analyses and a high frequency burst detection algorithm. RESULTS: Low frequency power increased with age; however, high frequency power decreased from 35 to 45 weeks. This unexpected decrease was largely attributable to a rapid decline in the number of high frequency bursts. CONCLUSIONS: The decline in high frequency bursting activity overlaps with a developmental shift in GABA's actions on neurons from depolarizing to hyperpolarizing and the dissolution of the gap junction circuitry of the cortical subplate. SIGNIFICANCE: We postulate that quantitative characterization of features of the EEG unique to early development provide indices for tracking changes in specific neurophysiologic mechanisms that are critical for normal development of brain function.
Assuntos
Ondas Encefálicas/fisiologia , Encéfalo/fisiologia , Córtex Cerebral/fisiologia , Desenvolvimento Infantil/fisiologia , Recém-Nascido Prematuro/fisiologia , Algoritmos , Encéfalo/crescimento & desenvolvimento , Eletroencefalografia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , PolissonografiaRESUMO
Neonatal central cyanosis is always a sign of serious pathological processes and may involve diverse organs and impose a significant diagnostic and therapeutic challenge. Here, we report an unusual presentation of Ebstein's anomaly, a rare congenital heart malformation, as the cause of central cyanosis in a one-week-old full-term infant. Initiation of PEG(1) therapy in neonates with Ebstein's anomaly always needs a very careful consideration because of a high risk for the development of a "circular shunt" leading to severe deterioration of multiple organs perfusion.
