RESUMO
Epidemic dropsy, a disease due to Argemone mexicana poisoning, is characterized by pathological accumulation of diluted lymph in body tissues and cavities. Recently, the largest epidemic of the disease in India affected Delhi and its neighboring states during the months of August-September 1998. Over 3000 persons fell ill, and more than 65 died in the state of Delhi alone. Two cases belonging to the same family died, out of the large number of cases admitted in this tertiary care teaching hospital situated in eastern part of Delhi. Autopsy findings of these two cases are presented and discussed here along with the review of toxicity due to this poisoning.
Assuntos
Autopsia/métodos , Óleos de Plantas/intoxicação , Toxicologia/métodos , Causas de Morte , Criança , Pré-Escolar , Surtos de Doenças/estatística & dados numéricos , Feminino , Humanos , Índia , Masculino , Óleos de Plantas/química , Intoxicação/diagnóstico , Intoxicação/epidemiologia , Estações do AnoRESUMO
The effect of trituration on thermal degradation of lactose (sugar of milk) was studied using a thermogravimetric analyser. A correlation between the rate of degradation with increased potency observed up to 600§C suggests that the vehicle plays an important role in the bioavailability of the drug. Comparison was also made between machine and hand tritured lactose. For lower potencies (up to the 2x) machine triturated lactose was found to degrade faster than hand triturated lactose, whereas at higher potencies hand triturated lactose showed faster degradation as compared to machine triturated lactose (AU)