RESUMO
BACKGROUND: Several studies have focused on the safety of withholding anticoagulant therapy in patients with negative results on helical computed tomography (CT). However, these studies were either retrospective or had a selection bias, since spiral CT was performed only in selected patients. Moreover, no special attention has been directed towards an alternative diagnosis which might explain patients' signs and symptoms. OBJECTIVES: To determine the safety of withholding anticoagulants in patients with clinically suspected pulmonary embolism (PE) and negative CT results when ultrasonography (US) was performed only in patients with clinical suspicion of deep vein thrombosis (DVT). Another goal was to evaluate the effect of CT findings on the final clinical diagnosis. METHODS: Among 192 consecutive patients who underwent CT for possible acute PE, 98 patients had negative images and 88 of them-- without clinical suspicion of DVT-- were prospectively followed up for 3 months for evidence of subsequent thromboembolic disease. They did not receive anticoagulation. Clinical probability of PE was assessed applying the Geneva score. These patients were also classified into several diagnostic categories according to the CT findings and clinical presentation. In addition, all patients who were alive (or a member of his or her family) were interviewed by phone once the last patient's follow-up was completed. RESULTS: One patient was lost to follow-up. Among the remaining 87 patients (35 with low, 47 with intermediate and 5 with high clinical probability), subsequent thromboembolic disease was found in 1 (1.1%; 95%CI: 0.03-6.2%). Two patients died during the follow-up period, but no deaths were attributed to PE. Alternative diagnoses were: nonspecific thoracic pain (43.3%), nonspecific pleuritis (19.5%), pneumonia (18.4%), other (18.8%). The telephone survey was performed in 74 patients (median follow-up: 11 months; range: 4-23). None of them had newly diagnosed episodes of PE and none of them had received anticoagulation for any reason. CONCLUSIONS: With the limitations of a small single-center series, our data suggest that withholding anticoagulation in patients with suspected acute PE and negative CT results appears to be safe when the clinical probability of PE is assessed as low or intermediate. This technique also provides useful information to pose an alternative diagnosis. US could be avoided in patients without clinical suspicion of DVT.
Assuntos
Anticoagulantes/uso terapêutico , Embolia Pulmonar/tratamento farmacológico , Anticoagulantes/administração & dosagem , Esquema de Medicação , Empiema/diagnóstico por imagem , Humanos , Derrame Pleural/diagnóstico por imagem , Pneumonia/diagnóstico por imagem , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/etiologia , Segurança , Trombose/complicações , Tomografia Computadorizada EspiralRESUMO
OBJECTIVE: To assess differences in the brachial plexus block in 2 groups who received the same dose of levobupivacaine: 1 group received a small volume of solution at high concentration and the other group received a large volume in solution at low concentration. MATERIAL AND METHODS: A prospective, randomized clinical trial enrolling 69 patients scheduled for wrist and/or hand surgery with a brachial plexus block with levobupivacaine in the humeral canal. Nerve stimulation was used to locate a response from the 4 terminal nerves in the brachial plexus. In the group receiving a larger volume, 10 mL of a solution of levobupivacaine at a concentration of 0.375% was used for each nerve. In the high concentration group receiving a smaller volume, levobupivacaine was used at a concentration of 0.75% in 5 mL for each nerve. Sensory latency was assessed by the pin prick technique. Motor block, the success rate (percentage), and duration of sensory and motor blockades were also evaluated. RESULTS: The full sensory block was significantly more efficacious in the large volume group than in the high concentration group (85.3% vs 51.6%, P = 0.003). A full motor block was reached in a small percentage of patients in both groups. There were no significant differences in latency or duration of block. CONCLUSIONS: The success rate was lower in the group receiving the smaller volume at a higher concentration. It is advisable to administer local anesthetics in larger volumes at lower concentrations to improve block quality. Latency and duration were similar in both groups.
Assuntos
Anestésicos Locais/administração & dosagem , Plexo Braquial , Bloqueio Nervoso , Bupivacaína/administração & dosagem , Bupivacaína/análogos & derivados , Feminino , Humanos , Levobupivacaína , Masculino , Pessoa de Meia-Idade , Bloqueio Nervoso/métodos , Estudos ProspectivosRESUMO
OBJETIVO: Valorar las diferencias en el bloqueo del plexo braquial entre dos grupos en los que se emplea la misma dosis de levobupivacaína: un grupo con bajo volumen/alta concentración y el otro con alto volumen/ baja concentración. MATERIAL Y MÉTODOS: Estudio prospectivo randomizado de 69 pacientes programados para cirugía de muñeca y/o mano, a los que se realizó un bloqueo del plexo braquial en el canal humeral con levobupivacaína. Se buscó la respuesta de los cuatro nervios terminales del plexo braquial mediante neuroestimulación. En el grupo volumen se utilizó levobupivacaína al 0,375%, 10 mL en cada nervio y en el grupo concentración se utilizó levobupivacaína al 0,75%, 5 mL en cada nervio. Se valoró la latencia sensitiva del bloqueo mediante la técnica del pinchazo, el bloqueo motor y el porcentaje de éxito de la técnica. También se recogió la duración del bloqueo sensitivo y motor. RESULTADOS: En el grupo volumen, el bloqueo sensitivo completo fue significativamente más efectivo que en el grupo concentración (85,3% vs 51,6%; p=0,003). El bloqueo motor completo se alcanzó en un porcentaje bajo de pacientes en ambos grupos. No hubo diferencias significativas en cuanto a la latencia y a la duración del bloqueo. CONCLUSIONES: Se obtuvo un bajo porcentaje de éxitos en el grupo bajo volumen/alta concentración. Es aconsejable utilizar volúmenes más elevados de anestésico local para mejorar la calidad del bloqueo. La latencia y la duración en ambos grupos fueron similares (AU)
OBJECTIVE: To assess differences in the brachial plexus block in 2 groups who received the same dose of levobupivacaine: 1 group received a small volume of solution at high concentration and the other group received a large volume in solution at low concentration. MATERIAL AND METHODS: A prospective, randomized clinical trial enrolling 69 patients scheduled for wrist and/or hand surgery with a brachial plexus block with levobupivacaine in the humeral canal. Nerve stimulation was used to locate a response from the 4 terminal nerves in the brachial plexus. In the group receiving a larger volume, 10 mL of a solution of levobupivacaine at a concentration of 0.375% was used for each nerve. In the high concentration group receiving a smaller volume, levobupivacaine was used at a concentration of 0.75% in 5 mL for each nerve. Sensory latency was assessed by the pin prick technique. Motor block, the success rate (percentage), and duration of sensory and motor blockades were also evaluated. RESULTS: The full sensory block was significantly more efficacious in the large volume group than in the high concentration group (85.3% vs 51.6%, P=0.003). A full motor block was reached in a small percentage of patients in both groups. There were no significant differences in latency or duration of block. CONCLUSIONS: The success rate was lower in the group receiving the smaller volume at a higher concentration. It is advisable to administer local anesthetics in larger volumes at lower concentrations to improve block quality. Latency and duration were similar in both groups (AU)