1.
Lab Chip
; 12(5): 916-22, 2012 Mar 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22252585
RESUMO
Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.