RESUMO
New Jersey Caucasian, African American, and Hispanic genotype and allele frequencies were determined for the six PCR-based loci, HLA-DQA1, LDLR, GYPA, HBGG, D7S8, and Gc. All but one locus (HLA-DQA1 for African Americans) meet Hardy-Weinberg expectations. However, observing one departure in 18 loci over the three New Jersey sample populations is not unexpected. There is little evidence for departures from independence between pairs of loci in the three populations studied. Thus, multiple locus profile frequencies can be determined using the product rule.
Assuntos
População Negra/genética , DNA/análise , Genética Populacional , Hispânico ou Latino/genética , População Branca/genética , Alelos , Impressões Digitais de DNA/métodos , Frequência do Gene , Marcadores Genéticos , Genótipo , Glucanos/genética , Glicoforinas/genética , Antígenos HLA-DQ/genética , Cadeias alfa de HLA-DQ , Humanos , New Jersey , Reação em Cadeia da Polimerase , Polimorfismo Genético/genética , Receptores de LDL/genética , Proteína de Ligação a Vitamina D/genéticaRESUMO
Allele frequencies for six PCR-based loci and three protein-based (i.e., enzyme systems) loci were determined in a Caucasian sample population from New Jersey. The loci are LDLR, GYPA, HBGG, D7S8, Gc, HLA-DQA1, PGM1, ESD, and EAP. All loci meet Hardy-Weinberg expectations. In addition, there is little evidence for association of alleles among the nine loci. The allelic frequency data generally are similar to another Caucasian population database.
