RESUMO
A high-grade diffuse T cell lymphoma, initially simulating bilateral panuveitis, was diagnosed by analysis of a vitreous biopsy specimen and a breast tumor in a 57-year-old woman. It responded favorably to aggressive chemotherapy before it relapsed in leukemic transformation. This case emphasizes the misleading initial symptoms of primary intraocular lymphoma and the role of immunophenotyping in the diagnosis and classification of lymphoproliferative ocular disorders. The presentation and management of uveal lymphoid neoplasia are discussed.
Assuntos
Granuloma/etiologia , Linfoma de Células T/complicações , Pan-Uveíte/etiologia , Neoplasias Uveais/complicações , Diagnóstico Diferencial , Feminino , Granuloma/diagnóstico , Humanos , Linfoma de Células T/diagnóstico , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Pan-Uveíte/diagnóstico , Neoplasias Uveais/diagnósticoRESUMO
The craniopharyngioma is a benign tumor located at least in part in the suprasellar cistern. The symptoms are determined not only by the position of the tumor but also by its size and the age of the patient. The goal of our study is to analyse retrospectively the manifestations of craniopharyngioma and their prognosis after treatment in function of the age.
Assuntos
Craniofaringioma/diagnóstico , Craniofaringioma/terapia , Neoplasias Hipofisárias/diagnóstico , Neoplasias Hipofisárias/terapia , Adolescente , Adulto , Criança , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Prognóstico , Acuidade VisualRESUMO
The main haemostasis changes observed in a screening study performed in 40 patients who underwent an open heart surgery with extracorporeal circulation (ECC) are: a significant drop in platelet count from the onset of the ECC to the third postoperative day, a decrease of platelet retention and aggregation during ECC with an 8-day persistently increased heparin-neutralizing activity in plasma but not in serum, a moderate decrease of plasma factors I, II, VII-X, X and XIII and a more important drop in factor V which disappears 24 h after ECC, a transitory increase of fibrinolysis during ECC and the lack of FDP elevation in the serum. These disorders require a very good neutralization of the heparin used during ECC. The ratio protamine/heparin can be established by a titration clotting time test. Protamine chloride seems to be more efficacious and to act more quickly than protamine sulfate for the neutralization. An overload in protamine can enhance the hemostatic, biological and clinical disorders. The preventive administration of platelet concentrate immediately after the heparin neutralization contributes to reduce the bleeding disorders related to the quantitative and qualitative platelet defects.