RESUMO
We have described a 38-year-old woman with a lesion of the cervix found on routine physical examination. The lesion proved to be a primary leiomyosarcoma of the cervix. Despite radiation therapy, surgery, and chemotherapy, the tumor recurred and grew relentlessly. She is alive with disease at two years seven months after initiation of therapy. The biologic behavior of leiomyosarcoma appears to be quite different from that of squamous cell carcinoma of the cervix.
Assuntos
Leiomiossarcoma/patologia , Neoplasias do Colo do Útero/patologia , Adulto , Feminino , HumanosAssuntos
Extratos Vegetais/farmacologia , África , Animais , Atropina/farmacologia , Gatos , Hemodinâmica/efeitos dos fármacos , Técnicas In Vitro , Contração Muscular/efeitos dos fármacos , Contração Miocárdica/efeitos dos fármacos , Extratos Vegetais/antagonistas & inibidores , Plantas Medicinais , CoelhosRESUMO
The actions of 100-2500 mug ketamine hydrochloride per ml Ringer solution were examined on the various components of the compound nerve volley of isolated sciatic-tibial nerves of toads. The smaller diameter fibres were blocked first and fibres of progressively larger diameter were blocked with increasing ketamine concentration. A progressive reducton in conduction velocities and amplitude, as well as increasing thresholds, accompanied increased drug contact and concentration. A preliminary trial on human volunteers revealed an apparent loss of pain and thermal sensations following subcutaneous injection.
