Bambusa arundinacea leaves extract-derived Ag NPs: evaluation of the photocatalytic, antioxidant, antibacterial, and anticancer activities.

Bio-fabrication has become a safe approach for silver nanoparticles (Ag NPs). The plant-mediated biosynthesized Ag NPs have emerged as a potential substitute for conventional chemical formation. The biosynthesized Ag NPs were analyzed in terms of crystalline nature, morphology, chemical composition, particle size, stability, size, and shape of the particles. The XRD, FTIR, and TEM analysis indicate the presence of the bioactive secondary metabolites compounds. The bamboo-mediated Ag NPs demonstrated a notable antibacterial efficacy against Gram-positive and Gram-negative pathogenic microorganisms and showed significant antioxidant activity against DPPH free radicals. The degradation of methylene blue at various intervals under solar light irradiation was used to evaluate the photocatalytic performance of Ag NPs. Further, Ag NPs conveyed potent anticancer activity against MCF-7 cell lines with a significant value IC50. The bamboo leaves-mediated Ag NPs synthesized Ag NPs signified strong antibacterial, antioxidant, and anticancer activity; hence, it can be used in various biomedical applications and face mask coating to prevent the coronavirus after successful clinical trials in research laboratories.

Biosynthesis of MgO nanoparticles using mushroom extract: effect on peanut (Arachis hypogaea L.) seed germination.

Current study describes the green, environmental friendly, and cost-effectiveness technique for the preparation of MgO nanoparticles (NPs) via white button mushroom aqueous extract. The synthesized MgO NPs were characterized using equipments such as X-ray diffraction, dynamic light scattering (DLS), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), and thermal gravimetric analysis (TGA) for average crystalline size, particle size, morphology, elemental analysis, and weight loss of the materials, respectively. This study reports the application of gardened sizes of (20, 18.5, 18, 16.5, and 15 nm) biosynthesized MgO NPs on seed germination. The smaller size (15 nm) MgO NPs have been enhanced the seed germination and growth parameters as compared with remaining sizes of MgO NPs and control. The magnesium oxide NPs penetrates into peanut seeds and affecting on seed germination and growth rate mechanism. In addition, this germination found to be high in seeds than germination on selected soil plot MgO NPs (0.5 mg/L stable concentrations) compared to different size of MgO NPs and control. Physicochemical methods indicated that the MgO NPs are able to penetrate into the seed coat and support water uptake inside of seeds. Probably, this positive effect may cause for the uptake of MgO NPs by the plants, as indicated in the UV and SEM analyses. As the smaller size (15 nm) of MgO NPs particles stimulates the development of seedling and growth enhancement of peanut, it clearly indicates that the current study is helpful in growing of peanuts in large-scale agricultural production.

Fe3O4 Nanoparticles Mediated Synthesis of Novel Isatin-dihydropyrimidinone Hybrid Molecules as Antioxidant and Cytotoxic Agents.

BACKGROUND: The present study emphasizes on designing a new series of isatin-dihydropyrimidinone derivatives by adopting a hybrid pharmacophore approach. Fe3O4 nanoparticles (Fe3O4 NP) are magnetically recoverable and are effective catalysts adequately used to synthesize Isatin-dihydropyrimidinones. Individual derivatives of Isatin and dihydropyrimidinone are equipotent to treat cytotoxicity. OBJECTIVE: The present work was planned to fuse two pharmacophores (Isatin, dihydropyrimidinone) and to examine any synergistic effect in the anticancer activity. METHOD: The individual compounds are synthesized by adopting appropriate synthetic routes like sandmayers and biginellis reaction and are fused together by using glacial acetic acid and Methanolic KOH to form novel Isatindihydropyrimidinone hybrids. All the new series of hybrids 7a-l were characterized by FT-IR, 1H NMR, 13C NMR, elemental analysis and Mass spectroscopy. The antioxidant activity of the synthesized compounds was assessed by using two models: 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and Hydrogen peroxide (H2O2) scavenging assay. RESULTS: From the results it can be inferred that nearly all the synthesized compounds have shown antioxidant activity at the tested dose as correlated with the standard ascorbic acid. The in vitro cytotoxic activity was assayed by using MTT assay. Compound 7l with IC50 values 22.13, 25.68 and 35.59 µM has significantly greater potency against MCF- 7, HeLa and IMR-32 cell lines. CONCLUSION: The compounds with halogen and electron withdrawing groups at the C-5 position of isatin ring exhibited significant antioxidant and cytotoxic activity.