COVID-19 New Cases and Environmental Factors During Wet and Dry Seasons in West and Southern Africa.

Sub-Saharan Africa has been the last continent to experience a significant number of cases in the novel Coronavirus (COVID-19). Studies suggest that air pollution is related to COVID-19 mortality; poor air quality has been linked to cardiovascular, cerebrovascular, and respiratory diseases, which are considered co-morbidities linked to COVID-19 deaths. We examine potential connections between country-wide COVID-19 cases and environmental conditions in Senegal, Cabo Verde, Nigeria, Cote D'Ivorie, and Angola. We analyze PM2.5 concentrations, temperatures from cost-effective in situ measurements, aerosol optical depth (AOD), and fire count and NO2 column values from space-borne platforms from 1 January 2020 through 31 March 2021. Our results show that the first COVID-19 wave in West Africa began during the wet season of 2020, followed by a second during the dry season of 2020. In Angola, the first wave starts during the biomass burning season but does not peak until November of 2020. Overall PM2.5 concentrations are the highest in Ibadan, Nigeria, and coincided with the second wave of COVID-19 in late 2021 and early 2022. The COVID-19 waves in Cabo Verde are not in phase with those in Senegal, Nigeria, and Cote, lagging by several months in general. Overall, the highest correlations occurred between weekly new COVID-19 cases meteorological and air quality variables occurred in the dry season.

Classifying the unclassifiable-a Delphi study to reach consensus on the fibrotic nature of diseases.

BACKGROUND: Traditionally, clinical research has focused on individual fibrotic diseases or fibrosis in a particular organ. However, it is possible for people to have multiple fibrotic diseases. While multi-organ fibrosis may suggest shared pathogenic mechanisms, yet there is no consensus on what constitutes a fibrotic disease and therefore fibrotic multimorbidity. AIM: A Delphi study was performed to reach consensus on which diseases may be described as fibrotic. METHODS: Participants were asked to rate a list of diseases, sub-grouped according to eight body regions, as 'fibrotic manifestation always present', 'can develop fibrotic manifestations', 'associated with fibrotic manifestations' or 'not fibrotic nor associated'. Classifications of 'fibrotic manifestation always present' and 'can develop fibrotic manifestations' were merged and termed 'fibrotic'. Clinical consensus was defined according to the interquartile range, having met a minimum number of responses. Clinical agreement was used for classification where diseases did not meet the minimum number of responses (required for consensus measure), were only classified if there was 100% consensus on disease classification. RESULTS: After consulting experts, searching the literature and coding dictionaries, a total of 323 non-overlapping diseases which might be considered fibrotic were identified; 92 clinical specialists responded to the first round of the survey. Over three survey rounds, 240 diseases were categorized as fibrotic via clinical consensus and 25 additional diseases through clinical agreement. CONCLUSION: Using a robust methodology, an extensive list of diseases was classified. The findings lay the foundations for studies estimating the burden of fibrotic multimorbidity, as well as investigating shared mechanisms and therapies.

Social isolation and mental health: Evidence from adults with serious mental illness.

OBJECTIVE: In the United States, loneliness is increasingly becoming a public health crisis. Individuals with serious mental illness (SMI) report loneliness at rates much higher than the general population. In this secondary data analysis, we examine how subjective and objective social isolation influence perceptions of mental health and well-being. METHOD: Using a cross-sectional design, we conducted a multivariate hierarchical regression analysis to determine the unique influence both subjective and objective isolation had on perceptions of mental health and well-being in adults with SMI. RESULTS: Rates of reported loneliness in those with SMI was consistent with the literature. Increased perceptions of loneliness were found to be a significant predictor of decreased self-report mental health rating and increased frequency of bothersome symptoms. Increased perceptions of social support were also a significant predictor in increased self-report mental health rating and frequency of bothersome symptoms. CONCLUSION AND IMPLICATIONS FOR PRACTICE: For social workers and providers of services to individuals with SMI, it is important to understand the prevalence of loneliness in the population. It is also critical to provide those with SMI social support and inclusion interventions that aim to increase perceptions of mental well-being. Additionally, the distinction between subjective and objective social isolation provides evaluators of social support interventions a more accurate definition from which to measure. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Simultaneous contrast improvement and temporal compression using divided-pulse nonlinear compression.

We experimentally demonstrate how divided-pulse nonlinear compression can be used to improve the temporal contrast of a laser pulse train while simultaneously temporally compressing the pulses. We measure a contrast improvement of almost four orders of magnitude on a nanosecond time scale and temporally compress the pulses from 1.2 ps to 187 fs. The efficiency of our method is also competitive with other contrast improvement methods, with 72% efficiency measured for the main pulse. We expect the method will be useful in the continuing development of high-power, Yb regenerative amplifiers, which suffer from both significant prepulses and relatively long pulse durations.

Energy scaling beyond the gas ionization threshold with divided-pulse nonlinear compression.

We demonstrate how pulse energy in hollow-core fiber can be scaled beyond gas-ionization limitations using divided-pulse nonlinear compression. With one pulse, ionization limits our fiber's output pulse energy to 2.7 mJ at an input of 4 mJ. By dividing the pulse to four low-energy pulses before the fiber, we eliminated the ionization and scaled the pulse energy 2.5× to 6.6 mJ at an input energy of 10 mJ. Larger energy scaling is possible, as our maximum pulse energy has not reached the new gas ionization threshold. Our results motivate applying the method to state-of-the-art systems for large pulse energy scaling without prohibitive system size increases.

The Role of Meteorological Variables and Aerosols in the Transmission of COVID-19 During Harmattan Season.

The role of atmospheric parameters and aerosols in the transmission of COVID-19 within tropical Africa, especially during the harmattan season, has been under-investigated in published papers. The harmattan season within the West African region is associated with significant dust incursion from the Bodele depression and biomass burning. In this study, the correlation between atmospheric parameters (temperature and humidity) and aerosols with COVID-19 cases and fatalities within seven locations in tropical Nigeria during the harmattan period was investigated. COVID-19 infection cases were found to be significantly positively correlated with atmospheric parameters (temperature and humidity) in the southern part of the country while the number of fatalities showed weaker significant correlation with particulate matters only in three locations. The significant correlation values were found to be between 0.22 and 0.48 for particulate matter and -0.19 to -0.32 for atmospheric parameters. Although, temperature and humidity showed negative correlations in some locations, the impact is smaller compared to particulate matter. In December, COVID-19 cases in all locations showed strong correlation with particulate matter except in Kano State. It is suggested that a reduction in atmospheric particulate matter can be used as a control measure for the spread of COVID-19.

Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation.

Keratinocytes produce lipids that are critical for the skin barrier, however, little is known about the impact of age on fatty acid (FA) biosynthesis in these cells. We have examined the relationship between keratinocyte FA composition, lipid biosynthetic gene expression, gene promoter methylation and age. Expression of elongase (ELOVL6 and 7) and desaturase (FADS1 and 2) genes was lower in adult versus neonatal keratinocytes, and was associated with lower concentrations of n-7, n-9 and n-10 polyunsaturated FA in adult cells. Consistent with these findings, transient FADS2 knockdown in neonatal keratinocytes mimicked the adult keratinocyte FA profile in neonatal cells. Interrogation of methylation levels across the FADS2 locus (53 genomic sites) revealed differential methylation of 15 sites in neonatal versus adult keratinocytes, of which three hypermethylated sites in adult keratinocytes overlapped with a SMARCA4 protein binding site in the FADS2 promoter.

The role of adjuvant radiotherapy in locally advanced T4 mandible squamous cell carcinoma in the N0 patient: a single centre experience.

In locally advanced oral squamous cell carcinoma (OSCC), namely that showing invasion of the mandible, demonstrating no high-risk (e.g. extranodal extension, positive margin) or intermediate-risk histopathological features (e.g. perineural invasion, lymphovascular invasion), the additional benefit of postoperative radiotherapy (PORT) currently remains uncertain. A retrospective review covering the period between January 1, 2010 and December 31, 2019 was conducted to identify patients from a single UK centre with locally advanced invasive mandibular OSCC defined as pT4a, with no nodal or distant metastasis (N0 M0). The primary outcome was to determine the disease-free survival and overall survival rates in the surgery + PORT group, in comparison to the surgery only group. Twenty-eight eligible patients were identified, with 13 patients in the surgery + PORT group and 15 patients in the surgery only group. A single patient in the surgery + PORT group developed disease recurrence and subsequently died (1/13) (median follow-up 5.24 years, range 2.13-10.71 years). No patient in the surgery only group developed disease recurrence or died (0/15) (median follow-up 5.13 years, range 1.37-10.93 years). It may be reasonable to consider omitting PORT in pT4a pN0 M0 OSCC of the mandible in patients who demonstrate no high- or intermediate-risk histopathological features, following multidisciplinary team discussion.

Malignant transformation of calcifying epithelial odontogenic tumour with solitary pulmonary metastasis.

This report describes the management of a case of calcifying epithelial odontogenic tumour (CEOT) that underwent malignant transformation and metastasized to the lung. The solitary pulmonary metastasis was discovered incidentally on computed tomography (CT) imaging of the neck. It appears that only one previous case with proven pulmonary metastasis has been reported in the literature, which involved multiple pulmonary deposits managed with platinum chemotherapy. The long-term prognosis of metastatic CEOT is therefore unknown. In the case presented here, the patient was managed successfully with surgery alone. There is often diagnostic uncertainty because histological features of benign, recurrent, and malignant CEOT are not dissimilar. Ki-67 immunohistochemistry is helpful, as higher levels are more indicative of malignancy. We consider that in cases of suspected recurrent and malignant CEOT, CT imaging of the thorax and abdomen as part of follow-up may identify metastases early, resulting in earlier treatment, an improved prognosis, and reduced morbidity and mortality.

Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis.

Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory Syndrome (SARS) survivor's consequent to SARS-Cov-2 infection. Thus there is an urgent medical need for identification of readily available biomarkers that in patients with SARS-Cov-2 infection are able to; (1) identify patients in most need of medical care prior to admittance to an intensive care unit (ICU), and; (2) identify patients post-infection at risk of developing persistent fibrosis of lungs with subsequent impaired quality of life and increased morbidity and mortality. An intense amount of research have focused on wound healing and Extracellular Matrix (ECM) remodelling of the lungs related to lung function decline in pulmonary fibrosis (PF). A range of non-invasive serological biomarkers, reflecting tissue remodelling, and fibrosis have been shown to predict risk of acute exacerbations, lung function decline and mortality in PF and other interstitial lung diseases (Sand et al. in Respir Res 19:82, 2018). We suggest that lessons learned from such PF studies of the pathological processes leading to lung function decline could be used to better identify patients infected with SARS-Co-V2 at most risk of acute deterioration or persistent fibrotic damage of the lung and could consequently be used to guide treatment decisions.

Soil nitrogen accumulation, denitrification potential, and carbon source tracing in bioretention basins.

Bioretention basins are one of the most commonly used green stormwater features, with the potential to accumulate significant levels of nitrogen (N) in their soil and to permanently remove it through denitrification. Many studies have investigated the N removal potential of bioretention basins through the assessment of inflow and outflow concentrations. However, their long-term N removal through soil accumulation and denitrification potential is less known. This study investigated the temporal variation of total N (TN) accumulation and denitrification potential in soils of 25 bioretention basins within a 13-year soil chronosequence, in a subtropical climate in Australia. The denitrification potential of a subset of seven bioretention basins was investigated in accompaniment with nutrient and soil characteristics. Additionally, stable isotopes (δ13C and δ15N) were used to assess temporal changes in the soil composition as well as to identify the sources of carbon (C) into these basins. Over 13 years of operation, TN accumulated faster in the top 5 cm of soil than deeper soils. Soil TN density was highest in the top 5 cm with an average of 1.4 kg N m-3, which was about two times higher than deeper soils. Site age and soil texture were the best predictors of soil TN density and denitrification (1 to 9.7 mg N m-2 h-1). The isotope values were variable among basins. Low δ15N values in young basins (-1.02‰) suggested fixation as the main source of N, while older basins had higher δ15N, indicating higher denitrification. Bioretention plants were the primary source of soil C; although the occurrence of soil amendment also contributed to the C pool. To improve the performance of these bioretention basins, we recommend increasing vegetation at initial years after construction, and enhancing more frequent anaerobic conditions in the high soil profile. These two conditions can improve denitrification potential, and thus the performance of these basins for improving water quality.

Overcoming gas ionization limitations with divided-pulse nonlinear compression.

We simulate Kerr and plasma nonlinearities in a hollow-core fiber to show how plasma effects degrade the output pulse. Our simulations predict the plasma effects can be avoided entirely by implementing divided-pulse nonlinear compression. In divided-pulse nonlinear compression, a high-energy pulse is divided into multiple low-energy pulses, which are spectrally broadened in the hollow-core fiber and then recombined into a high-energy, spectrally broadened pulse. With the plasma effects overcome, spectral broadening can be scaled to larger broadening factors and higher pulse energies. We anticipate this method will also be useful to scale spectral broadening in gas-filled multipass cells.

Effect of breed as a risk factor for humeral condylar fracture in skeletally immature dogs.

OBJECTIVES: To investigate the effect of breed as a risk factor associated with humeral condylar fracture in skeletally immature dogs in the UK. MATERIALS AND METHODS: Retrospective study of dogs under 12 months of age that were presented with humeral condylar fracture to three specialist referral centres between 2015 and 2018. Data retrieved from medical records included breed, age, gender, neuter status, affected limb, fracture configuration and aetiology of the fracture. Breed population percentages were compared with those recorded by the UK Kennel Club. RESULTS: Of the 115 dogs with 118 fractures, French bulldogs (41%) and English springer spaniels (15%) were overrepresented: humeral condylar fractures were more commonly diagnosed in French bulldogs (odds ratio = 5.86) and English springer spaniels (odds ratio = 5.66) compared with mixed-breed dogs. Lateral condylar fractures occurred in 70% of cases, with medial condylar fractures and Y/T fractures accounting for 9% and 21%, respectively. Median age at the time of fracture was 4 months (range 2 to 10 months). CLINICAL SIGNIFICANCE: French bulldogs and English springer spaniels were identified as being at potentially increased risk of humeral condylar fracture in skeletally immature dogs.

Diaphragmotomy to aid exposure during hepatobiliary surgery: a multi-centre retrospective review of 31 dogs.

OBJECTIVES: To report surgical technique, intra- and post-operative complications, and short- and long-term outcome following canine hepatobiliary surgery in which exposure of intra-abdominal hepatobiliary lesions was aided by diaphragmotomy. MATERIALS AND METHODS: Clinical records from four multi-disciplinary UK-based small animal referral hospitals were retrospectively reviewed for dogs in which diaphragmotomy was performed between January 2014 and May 2019. Signalment, diagnosis, surgery performed, diaphragmotomy technique, management of diaphragmotomy and pneumothorax, intra- and post-operative complications, short-term outcome and long-term outcome were recorded. RESULTS: Thirty-one cases were identified. The most common hepatobiliary surgeries performed alongside diaphragmotomy were single hepatic lobectomy (14/31) and cholecystectomy (11/31). The most common diagnoses were hepatocellular carcinoma (10/31), gall bladder mucocoele (7/31) and hepatic nodular hyperplasia (4/31). Peri-operative mortality rate was 9.7% (3/31 cases) though none of these deaths were considered attributable to diaphragmotomy. Post-operative complications were encountered in 67.9% (19/28) cases that survived the peri-operative period, of which 25.0% (7/28) suffered complications that were considered attributable or likely attributable to diaphragmotomy. These seven complications resolved following non-surgical intervention. Follow-up was available for 26 of 28 patients that survived to discharge at a median of 4-months (range 10 days to 24 months) following surgery and revealed no evidence of complications related to diaphragmotomy. CLINICAL SIGNIFICANCE: Diaphragmotomy appears safe and increases abdominal exposure of hepatobiliary lesions. The benefit of improved exposure must be carefully weighed up against the risks inherent in inducing pneumothorax.

Critical Issues in Leadership Development for Peer Support Specialists.

This paper is a qualitative analysis of perspectives on leadership development among working peer support specialists and highlights the challenges, needs and efficacy these individuals experience in their work settings. Six participants engaged in a 2 h semi-structured focus group. Participants were guided through a series of nine questions regarding their transition to leadership, professional communication and relationships. Seven themes emerged: managing dual relationships; having difficult conversations; push and pull of leadership; taking responsibility for others; taking responsibility for self-care; addressing stigma in the workplace, and, spirituality/a calling to help. These professionals integrate their personal experiences of recovery into their direct care and leadership approaches in the workplace. This blending of recovery concepts and supervision approaches reflect some of the powerful elements that peer recovery specialists are uniquely qualified to lead in the healthcare workforce. These findings provide important implications for leadership development among this growing segment of the healthcare workforce.

Optical evidence of the chiral magnetic anomaly in the Weyl semimetal TaAs.

Chiral pumping from optical electric fields oscillating at terahertz frequencies is observed in the Weyl material TaAs with electric and magnetic fields aligned along both the a and c axes. Free-carrier spectral weight enhancement is measured directly, confirming theoretical expectations of chiral pumping. A departure from linear field dependence of the Drude weight is observed at the highest fields in the quantum limit, providing evidence of field-dependent Fermi velocity of the chiral Landau level. Implications for the chiral magnetic effect in Weyl semimetals from the optical f -sum rule are discussed.

Prediction of effects of dairy selection indexes on methane emissions.

Global warming caused by greenhouse gas emissions is a threat to the survival of humans and other organisms living on Earth. The greenhouse gases released from the dairy sector of New Zealand accounted for 18.2 Mt of carbon dioxide equivalent (CO2-eq) in 2016, mainly from methane generated by enteric fermentation in the rumen of milking cows and their replacement stock. A productivity commission established by the New Zealand government in 2018 estimated that methane emissions from livestock needed to be reduced from 2016 levels by 10 to 22% by 2050 (i.e., 2.8 to 6.1 million t lower), so as to restrict future increases in global temperature to less than 2°C. In this study, we evaluated genetic effects of 8 traits included in the New Zealand national dairy breeding objective, on 3 types of methane emissions metrics: gross methane emissions per dairy cow per year (E), methane emissions per hectare (EH), and methane emissions intensity per milk protein equivalents (EI), as carbon dioxide equivalents. These effects were then aligned with recent genetic changes in these traits brought about by breeding schemes, so that the overall genetic trend for each metric into the future was estimated. The results showed that EH and EI are currently being reduced at rates of -2.31 kg of CO2-eq per hectare per cow per year (current average is 6,915 kg of CO2-eq/ha per cow per year) and -0.04 kg of CO2-eq per kg of milk protein equivalents per cow per year, respectively (current average is 9.7 kg of CO2-eq/milk protein-eq per cow per year). These improvements directly reflect increased production efficiency through selection for farm profitability. If the pastureland area in New Zealand remains the same, at the same productivity and with no increase in supplementation rates from external land sources, in 20 years gross emissions would be reduced by only 0.6%, or 89 Mt. Increased production efficiency will likely result in corresponding changes to the stocking rate, to fully utilize the pasture resource available, and might further encourage a greater rate of intensification via supplementary feeding. Both consequences of current genetic selection could negate any benefits for the national greenhouse gas inventory. New selection criteria for reduced methane production are needed to help achieve New Zealand's national methane reduction targets.

Comparison of the piezoelectric cutter with a conventional cutting technique in orthognathic surgery.

The use of a piezoelectric cutter has been reported to improve outcomes in orthognathic surgery, particularly with regards to neurosensory disturbance of the inferior alveolar nerve. The aims of this retrospective longitudinal cohort study were to compare outcomes regarding neurosensory disturbance, and operating time. During two 15-month periods a single surgeon treated 24 consecutive patients with a conventional cutting technique and a further 24 consecutive patients with a piezoelectric cutter. In both groups the duration of operation was noted, and neurosensory disturbance graded at 12-month follow up. Neurosensory recovery was better in the piezoelectric group than in the conventional group (p=0.01), and the duration of operation nearly identical. We conclude that the piezoelectric cutter offers advantages with regards to neurosensory deficit over a more conventional technique without the previously-reported disadvantage of a longer operating time.

Changes in epidermal morphology associated with dandruff.

OBJECTIVE: Dandruff is a very common scalp condition characterized by flaking and pruritus usually with no visible signs of inflammation, such as redness and erythema. Dandruff is considered a multifactorial condition with both microbial colonization and host factors such as sebum production thought to play a role. There is evidence of changes in epidermal morphology in the scalp skin of dandruff sufferers, with reports of an increase in mean thickness and more nucleated cell layers. The underlying mechanisms driving these morphological changes are currently unclear. The objective of this study was to fully characterize epidermal morphology in dandruff compared to healthy scalp skin and to evaluate potential mechanisms underlying any changes observed. METHODS: Scalp skin biopsies were taken from 22 healthy female subjects and 21 dandruff sufferers, from both lesional and non-lesional sites. Samples were processed, sectioned and stained using haematoxylin and eosin (H&E). To fully characterize epidermal morphology, measurements were taken of epidermal thickness, the convolution of the dermal-epidermal junction and the depth of epidermal rete ridges. To analyse changes in epidermal proliferation immunohistochemical staining was performed using Ki67, a well-established marker of cell proliferation, and quantified using image analysis. RESULTS: Histochemical analysis of skin sections revealed that in dandruff lesional samples, the epidermis was thicker, had a more convoluted dermal epidermal junction and the rete ridges were elongated, compared to healthy scalp skin. Similar directional changes in epidermal morphology, were observed in non-lesional dandruff samples, albeit to a lesser extent. Image analysis of Ki67 expression in the epidermis revealed dandruff lesional skin contained significantly more Ki67-positive proliferating keratinocytes than healthy controls samples. This suggests dandruff scalp skin epidermal keratinocytes are in a hyper-proliferative state. CONCLUSION: There were significant changes in epidermal morphology in dandruff lesional skin compared to healthy scalp skin including increased epidermal thickness, a more convoluted dermal-epidermal junction and elongation of rete ridges. Interestingly, we found there was evidence of an increase in the percentage of epidermal Ki67-positive cells, which has not been reported previously, and demonstrates dandruff is a condition displaying epidermal hyper-proliferation.

OBJECTIF: Les pellicules constituent une affection du cuir chevelu très fréquente caractérisée par une desquamation et un prurit ne présentant pas, en général, des signes visibles d'inflammation, comme une rougeur et un érythème. Les pellicules sont considérées être une affection multifactorielle présentant une colonisation microbienne ainsi que des facteurs-hôtes, tels que la production de sébum, qui pourraient avoir un rôle à jouer. Il existe des preuves qu'il se produit des changements dans la morphologie épidermique de la peau du cuir chevelu des personnes qui ont des pellicules, et des rapports font cas d'une augmentation de l'épaisseur moyenne et d'un plus grand nombre de couches de cellules nucléées. Les mécanismes sous-jacents à ces changements morphologiques sont jusqu'ici peu élucidés. L'objectif de cette étude était de caractériser pleinement la morphologie épidermique en la présence de pellicules par comparaison à la peau du cuir chevelu sain, et d'évaluer les mécanismes potentiels sous-jacents à tout changement observé. MÉTHODES: Des biopsies de la peau du cuir chevelu ont été pratiquées chez 22 femmes en bonne santé et 21 femmes présentant des pellicules, dans des sites lésionnés et non lésionnés. Les échantillons ont été traités, coupés en lamelles et colorés en utilisant de l'hématoxyline et de l'éosine (H&E). Pour caractériser pleinement la morphologie épidermique, des mesures de l'épaisseur épidermique, de la convolution de la jonction dermo-épidermique et de la profondeur des crêtes du réseau épidermique ont été effectuées. Pour analyser les changements dans la prolifération épidermique, une coloration immunohistochimique a été réalisée en utilisant du Ki67, un marqueur bien établi de la prolifération cellulaire, et quantifiée à l'aide de l'analyse d'images. RÉSULTATS: L'analyse histochimique des sections de peau a révélé que, dans les échantillons de lésions avec pellicules, l'épiderme était plus épais, présentait une jonction dermo-épidermique plus compliquée et des crêtes du réseau plus allongées, par comparaison à la peau du cuir chevelu en bonne santé. Des changements directionnels analogues de la morphologie épidermique ont été observés dans les échantillons sans lésions et avec pellicules, toutefois en une moindre mesure. L'analyse des images de l'expression de Ki67 dans l'épiderme a révélé que la peau avec lésions et pellicules contenait des kératinocytes prolifératifs bien plus Ki67-positifs que les échantillons de témoins en bonne santé. Cela suggère que les kératinocytes épidermiques de la peau du cuir chevelu présentant des pellicules sont dans un état hyper-prolifératif. CONCLUSION: Il s'est produit des changements significatifs dans la morphologie épidermique de la peau avec lésions et pellicules, par comparaison à la peau du cuir chevelu en bonne santé, y compris un épaississement de l'épiderme, une jonction dermo-épidermique plus compliquée et un allongement des crêtes du réseau. Fait intéressant, nous avons découvert des signes d'augmentation du pourcentage de cellules épidermiques Ki67-positives, ce qui n'avait encore jamais été rapporté, et qui démontre que la présence de pellicules est une affection affichant une hyper-prolifération épidermique.

Nitrogen acquisition and resource allocation strategies in temperate seagrass Zostera nigricaulis: Uptake, assimilation and translocation processes.

The dominant seagrass in Port Phillip Bay (PPB), Australia, Zostera nigricaulis, declined between 2000 and 2011, coinciding with the 'Millennium drought' that ended in 2009. These seagrasses are nitrogen-limited, underpinning the need to develop nitrogen budgets for better ecosystem management. Environmentally realistic measurements of specific uptake rates and resource allocation were undertaken to develop nitrogen budgets and test the hypothesis that the above-ground and below-ground compartments are able to re-mobilise ammonium and nitrate through uptake, translocation and assimilation to adapt to varying levels of nitrogen in the ecosystem. Uptake of 15N labelled ammonium and nitrate by above- and below-ground seagrass biomass, epiphytes and phytoplankton was quantified in chambers in situ. Preferential uptake of ammonium over nitrate was observed, where the uptake rate for nitrate was about one sixth of that for ammonium. Epiphytes and phytoplankton also registered an increased affinity for ammonium over nitrate. Translocation experiments demonstrated the uptake by both the above-ground and below-ground biomass, respectively from the water column and pore water, and subsequent translocation to the opposite compartment. Acropetal translocation (below- to above-ground biomass) was more prevalent than basipetal translocation. This is a unique outcome given basipetal translocation has been widely reported for Zostera by other researchers.