Fall risk assessment dataset: older-adult participants undergoing the time up and go test.

This article presents a dataset comprising signal data collected from Inertial Measurement Unit (IMU) sensors during the administration of the Time Up and Go (TUG) test for assessing fall risk in older adults. The dataset is divided into two main sections. The first section contains personal, behavioral, and health-related data from 34 participants. The second section contains signal data from tri-axial acceleration and tri-axial gyroscope sensors embedded in an IMU sensor, which was affixed to the participants' waist area to capture signal data while they walked. The chosen assessment method for fall risk analysis is the TUG test, requiring participants to walk a 3-meter distance back and forth. To prepare the dataset for subsequent analysis, the raw signal data underwent processing to extract only the walking periods during the TUG test. Additionally, a low-pass filter technique was employed to reduce noise interference. This dataset holds the potential for the development of effective models for fall risk detection based on insights garnered from questionnaires administered to specialists who observed the experiments. The dataset also contains anonymized participant information that can be explored to investigate fall risk, along with other health-related conditions or behaviors that could influence the risk of falling. This information is invaluable for devising tailored treatment or rehabilitation plans for individual older adults. The complete dataset is accessible through the Mendeley repository."

Design of synthetic biological logic circuits based on evolutionary algorithm.

The construction of an artificial biological logic circuit using systematic strategy is recognised as one of the most important topics for the development of synthetic biology. In this study, a real-structured genetic algorithm (RSGA), which combines general advantages of the traditional real genetic algorithm with those of the structured genetic algorithm, is proposed to deal with the biological logic circuit design problem. A general model with the cis-regulatory input function and appropriate promoter activity functions is proposed to synthesise a wide variety of fundamental logic gates such as NOT, Buffer, AND, OR, NAND, NOR and XOR. The results obtained can be extended to synthesise advanced combinational and sequential logic circuits by topologically distinct connections. The resulting optimal design of these logic gates and circuits are established via the RSGA. The in silico computer-based modelling technology has been verified showing its great advantages in the purpose.

Design of synthetic genetic oscillators using evolutionary optimization.

Efforts have been made to establish computer models of genetic oscillation. We have developed a real structured genetic algorithm (RSGA) which combines advantages of the traditional real genetic algorithm (RGA) with those of the structured genetic algorithm (SGA) and applies it as an optimization strategy for genetic oscillator design. For the generalized design, our proposed approach fulfils all types of genes by minimizing the order of oscillator while searching for the optimal network parameters. The design approach is shown to be capable of yielding genetic oscillators with a simpler structure while possessing satisfactory oscillating behavior. In silico experiments show effectiveness of the proposed algorithm to genetic oscillator design. In particular, it is shown that the proposed approach performs better than the traditional GAs in the sense that a cheaper structure of genetic oscillators can be obtained.