Modeling emotional content of music using system identification.

Research was conducted to develop a methodology to model the emotional content of music as a function of time and musical features. Emotion is quantified using the dimensions valence and arousal, and system-identification techniques are used to create the models. Results demonstrate that system identification provides a means to generalize the emotional content for a genre of music. The average R2 statistic of a valid linear model structure is 21.9% for valence and 78.4% for arousal. The proposed method of constructing models of emotional content generalizes previous time-series models and removes ambiguity from classifiers of emotion.

Severe upper extremity injuries in frontal automobile crashes: the effects of depowered airbags.

BACKGROUND: The purpose of this study was to determine the effects of depowered frontal airbags on the incidence of severe upper extremity injuries. METHODS: The National Automotive Sampling System database files from 1993 to 2000 were examined in a study that included 2,413,347 occupants who were exposed to an airbag deployment in the United States. RESULTS: Occupants exposed to a depowered airbag deployment were significantly more likely to sustain a severe upper extremity injury (3.9%) than those occupants exposed to a full-powered airbag deployment (2.5%) (P=.01). Full-powered systems resulted in an injury distribution of 89.2% fractures and 7.9% dislocations compared with depowered systems with 55.3% fractures and 44.3% dislocations. CONCLUSIONS: Although depowered airbags were designed to reduce the risk of injuries, they appear to have increased the overall incidence of severe upper extremity injuries through a shift from long bone fractures to joint dislocations.

The effects of depowered airbags on skin injuries in frontal automobile crashes.

The purpose of this study was to determine the effects of depowered frontal airbags on the incidence of skin injuries. The National Automotive Sampling System database files from 1993 to 2000 were examined in a study including 2,246,524 occupants exposed to airbag deployment in the United States. There was no significant difference between full-powered and depowered airbags, with 60.2 percent of those exposed to a full-powered deployment sustaining a skin injury versus 59.5 percent of occupants exposed to a depowered airbag (p = 0.19). Whether occupants were exposed to a full-powered airbag (1,936,485 occupants) or a depowered airbay (310,039 occupants), the majority of skin injuries were to the upper extremity and the face. Regardless of airbag power, the overwhelming majority of the skin injuries were minor (99.8 percent). There was not a significantly greater risk of injury from any source for occupants exposed to a depowered airbag or a full-powered airbag (p = 0.87). The data suggest that the implementation of depowered airbags did not affect the number, seriousness, location, or source of skin injuries.

Analysis of burn injuries in frontal automobile crashes.

The purpose of this study was to investigate burn injuries resulting from frontal automobile crashes and to determine the effects of frontal airbags on the incidence of burn injuries. The study included 25,464 individual cases from the National Automotive Sampling System database files for the years 1993 to 2000. Occupants were at a significantly higher risk to sustain a burn injury when exposed to an airbag deployment (1.54%) compared with those who received a burn injury when not exposed to an airbag deployment (0.02%; P = 0.02). In contrast to previous publications, this study found that 1.53% of front seat occupants exposed to an airbag deployment sustained an airbag-induced burn injury. The vast majority of airbag-induced burn injuries were minor (98.7%); however, in cases with no airbag deployment, the burns were often much more serious, including fatal burns (29.6%). Occupant weight, height, sex, seatbelt use, and seat position were all found not to be significant in predicting the risk of airbag induced burn injury, whereas age and crash velocity were found to be significant.

The effects of airbag deployment on severe upper extremity injuries in frontal automobile crashes.

The purpose of this study was to investigate severe upper extremity injuries resulting from frontal automobile crashes and to determine the effects of frontal airbags. The National Automotive Sampling System database files from 1993 to 2000 were examined in a study that included 25,464 individual cases that occurred in the United States. An analysis of the cases indicated that occupants exposed to an airbag deployment were statistically more likely to sustain a severe upper extremity injury (2.7%) than those occupants not exposed to an airbag deployment (1.6%) (P =.01). In particular, 0.7% of occupants exposed to an airbag deployment sustained a severe upper extremity injury specifically from the airbag. In addition, when in crashes with an airbag deployment, older occupants were at a higher risk for severe upper extremity injury, as well as occupants in crashes with higher changes in velocity.

IgG in brain correlates with clinicopathological damage in HTLV-1 associated neurologic disease.

OBJECTIVE: To test the authors' hypothesis that antibody deposition in autopsy specimens from patients with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) would correlate with CNS damage. METHODS: Endogenous immunoglobulin G (IgG) was detected using antihuman IgG in autopsy tissues from HAM/TSP and control patients. IgG was isolated from the CSF, CNS, and sera of patients with HAM/TSP and tested for reactivity to heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), an autoantigen recently associated with molecular mimicry in HAM/TSP. RESULTS: In situ IgG localized to elements of the corticospinal system including neurons of the frontal cortex and precentral gyrus, as well as throughout axons in subcortical white matter, periventricular white matter, posterior limb of the internal capsule, midbrain, pons, and medulla. Similarly, there was IgG deposition within the posterior-column/medial lemniscal sensory system, including the arcuate fibers of the cranial-cervical junction, the nucleus cuneatus, and throughout the course of the medial lemniscus in the medulla, pons, and midbrain. IgG from brain, CSF, and serum of the patients with HAM/TSP showed immunoreactivity with hnRNP A1. CONCLUSION: Patients with HAM/TSP develop antibodies specific for neurons and axons that are preferentially damaged in the CNS.

The effects of airbags on orbital fracture patterns in frontal automobile crashes.

PURPOSE: To investigate orbital fractures that occurred in frontal automobile crashes and to determine the effects of frontal airbags on injury incidence and severity. METHODS: The National Automotive Sampling System database files from 1993 to 2000 were examined. Frontal crashes were selected that included drivers and front-seat passengers only and excluded ejected occupants and rollover crashes. Orbital fractures could be closed, open, displaced, or any combination of these and were identified by using the Abbreviated Injury Scale codes. RESULTS: The analysis included 12,429,580 front-seat occupants from 25,464 cases. Of all occupants who were exposed to an airbag deployment, 0.09% sustained an orbital fracture. In contrast, occupants who were not exposed to an airbag deployment were more than twice as likely to sustain an orbital fracture (0.22%). In addition to reduction in incidence, airbags were also shown to decrease the severity of orbital fractures that occupants sustained. Occupants exposed to airbag deployment mostly sustained closed, less severe fractures (61.9%), whereas occupants not exposed to airbag deployment sustained the majority as more severe, open, displaced, or comminuted fractures (61.3%). CONCLUSIONS: This article presents the most comprehensive study of orbital fractures in automobile crashes to date. It is shown that both the incidence and the overall severity of orbital fractures decreases considerably with exposure to airbag deployment. This is accomplished because the airbag minimizes occupant contact with the windshield and steering wheel, which are the two leading sources of orbital fractures for occupants not exposed to airbag deployment.

The effect of frontal air bags on eye injury patterns in automobile crashes.

OBJECTIVE: To investigate eye injuries resulting from frontal automobile crashes and to determine the effects of frontal air bags. METHODS: The National Automotive Sampling System database files from January 1, 1993, through December 31, 1999, were examined in a 3-part study that included an investigation of 22 236 individual crashes that occurred in the United States. A new 4-level eye injury severity scale that quantifies injuries based on recovery time, need for surgery, and possible loss of sight was developed. RESULTS: Of all occupants who were exposed to an air bag deployment, 3% sustained an eye injury. In contrast, 2% of occupants not exposed to an air bag deployment sustained an eye injury. A closer examination of the type of eye injuries showed that there was a statistically significant increase in the risk of corneal abrasions for occupants who were exposed to an air bag compared with those who were not (P =.03). Of occupants exposed to an air bag deployment, 0.5% sustained a corneal abrasion compared with 0.04% of occupants who were not exposed to an air bag. CONCLUSIONS: Using the new injury levels, it was shown that although occupants exposed to an air bag deployment had a higher risk of sustaining minor eye injuries, the air bag appears to have provided a beneficial exchange by reducing the number of severe eye injuries.

Determining the effectiveness of critical pathways for coronary artery bypass graft patients: retrospective comparison of readmission rates.

The article describes a study performed to determine whether the use of the critical path tool made a difference in the readmission rates of patients after coronary artery bypass graft (CABG) surgery compared with CABG patients cared for without the critical path tool. The sample for this retrospective study consisted of 780 specific patient medical records from the medical record department. Examination of the data revealed no statistically significant difference in readmission for CABG patients cared for with critical paths and those cared for without critical paths. A comparison of hospital length of stay and surgical length of stay between the two groups however, revealed statistically significant differences between the two groups. The critical path group had a significant decrease in hospital and surgical length of stay.

Induction of phenotypically altered mammary epithelial cells by neutrons and gamma rays.

These studies have examined alterations in the in vivo growth properties of mammary epithelial cells isolated at 1, 4, and 16 weeks after in vivo irradiation with -137Cs gamma rays or fission-spectrum neutrons. Altered in vitro growth potential was characterized by the proliferation of epithelial foci (EF) from irradiated animals under conditions in which mammary cells from nonexposed animals senesced. These EF were further characterized based on their ability to be subcultured. Both gamma and neutron irradiation resulted in the appearance of cells capable of forming EF. Further, with increased time in situ between irradiation and cell isolation, the frequency of EF which were capable of being subcultured indefinitely (EFs) increased. Reducing the gamma-ray dose rate resulted in fewer EFs while reducing the neutron dose rate resulted in increased frequencies of EFs. These data confirm earlier observations following gamma irradiation and show these cellular changes are also observed following neutron irradiation. In addition, these data indicate that changes in dose rate primarily influence the emergence of immortalized cell populations.

Estimation of bladder wall location in ultrasound images.

A method of automatically estimating the location of the bladder wall in ultrasound images is proposed. Obtaining this estimate is intended to be the first stage in the development of an automatic bladder volume calculation system. The first step in the bladder wall estimation scheme involves globally processing the images using standard image processing techniques to highlight the bladder wall. Separate processing sequences are required to highlight the anterior bladder wall and the posterior bladder wall. The sequence to highlight the anterior bladder wall involves Gaussian smoothing and second differencing followed by zero-crossing detection. Median filtering followed by thresholding and gradient detection is used to highlight as much of the rest of the bladder wall as was visible in the original images. Then a 'bladder wall follower'--a line follower with rules based on the characteristics of ultrasound imaging and the anatomy involved--is applied to the processed images to estimate the bladder wall location by following the portions of the bladder wall which are highlighted and filling in the missing segments. The results achieved using this scheme are presented.

Statistical pattern classification of clinical brainstem auditory evoked potentials.

The brainstem auditory evoked potentials (BAEPs) recorded in the neurological clinic were classified using the Bayes classifier (BC) and Fisher's linear discriminant function (FLD). The latencies of initial five peaks, interpeak intervals were examined for optimum features to develop classifiers. The accuracy of classification was 85.3% when absolute latencies of peaks III, IV and V were used as features. The BC gave better performance than FLD, indicating that second order statistics of BAEPs for normal and pathological classes are different. The results of this study indicate that latencies alone give enough information for recognizing normal from pathological BAEPs, using physician's evaluation of BAEPs as the reference.

Radiation carcinogenesis: time-dose relationships.

The present studies were undertaken to examine the time-dose relationships for the induction of lung adenocarcinomas and mammary adenocarcinomas in female BALB/c mice following gamma irradiation. Twelve-week-old female BALB/c/An NBd mice were irradiated with 137Cs gamma rays, and lifetime tumor incidences following high-dose-rate, low-dose-rate, or fractionated exposure regimens were compared. Analysis of the results indicated that the data could be fitted by linear-quadratic dose-response models for the induction of both tumors following acute doses and a linear model with a slope similar to that for the linear portion of the linear quadratic following low-dose-rate exposure regimens. When doses were fractionated the response was dependent upon the dose per fraction. If the dose per fraction was a dose which was predominantly on the linear portion of the acute dose response curve, then the response was linear and similar to that after low-dose-rate exposures. If the dose per fraction was in a region where the quadratic portion of the acute dose-response was significant, then the tumor incidence was higher than that following low-dose-rate exposures.

Classification of brain-stem auditory evoked potentials by syntactic methods.

A syntactic pattern recognition procedure for classification of brain-stem auditory evoked potential (BSAEP) is presented. A pre-processing stage of zero-phase bandpass filtering enhances the peaks and suppresses the noise. A finite-state grammar was designed to identify the peaks. Attributes of the peaks (latencies and amplitudes) that are identified are checked for their acceptability. A training run on 70 subjects of known diagnosis was performed to fine-tune the system and build up necessary acceptance criteria. Peak latency differences are used for the classification rather than absolute peak latencies. Acceptance criteria for peak latency differences were empirically optimized. A data base of normal BSAEPs, created during the training run, was updated and used during the test run. Test of the classifier using 60 subjects yielded a classification accuracy of 83%. The classifier has acceptable accuracy and can be modified for other evoked potentials such as visual and somatosensory by establishing relevant attribute tables.

Entropy-based texture analysis in the spatial frequency domain.

An approach which uses regional entropy measures in the spatial frequency domain for texture discrimination is presented. The measures provide texture discriminating information independent of that contained in the usual summed energy within based frequency domain features. Performance of the entropy features as measured by a between-to-within-class scatter criterion is comparable to that of traditional frequency domain features and gray level co-occurrence contrast features. A method of frequency scaling is introduced to enable the comparison of texture samples of different subimage size. The resulting regional entropy measures are subimage size-invariant subject to certain constraints which arise from properties of the discrete Fourier transform.