Dynamic control of circumrotation of a [2]catenane by acid-base switching.

Dynamic control of the motion in a catenane remains a big challenge as it requires precise design and sophisticated well-organized structures. This paper reports the design and synthesis of a donor-acceptor [2]catenane through mechanical interlocking, employing a crown ether featuring two dibenzylammonium salts on its side arms as the host and a cyclobis(paraquat-p-phenylene) (CBPQT ⋅ 4PF6 ) ring as the guest molecule. By addition of external acid or base, the catenane can form self-complexed or decomplexed compounds to alter the cavity size of the crown ether ring, consequently affecting circumrotation rate of CBPQT ⋅ 4PF6 ring of the catenane. This study offers insights for the design and exploration of artificial molecular machines with intricate cascading responsive mechanisms.

Aged black garlic extract inhibits the growth of estrogen receptor-positive breast cancer cells by downregulating MCL-1 expression through the ROS-JNK pathway.

The black garlic is produced from the raw garlic by Milliard reaction at high temperature (~60-90°C) and humidity (~70-90%). In this process, the pungent odor and gastrointestinal irritation effects of the raw garlic are reduced. At the same time, unstable compounds such as allicin are converted into stable organosulfur compounds with antioxidant activity. Previous studies have confirmed that black garlic extract has anti-tumor effects and could inhibit the proliferation of various tumor cells, including breast cancer cells MCF-7. However, the mechanisms of the anti-tumor effects remain unclear. In this study, we found that the black garlic extract could inhibit the proliferation, invasion, and metastasis of estrogen receptor-positive breast cancer cells, promote their apoptosis, and inhibit their epithelial-mesenchymal transition. Mechanistically, the black garlic extract reduced the expression of the anti-apoptotic protein MCL-1, which was achieved by modulating the ROS-JNK signaling pathway. In addition, the black garlic extract also decreased the expression of BCL-2 and increased the expression of BAX and BIM. We also found that the black garlic extract, in combination with venetoclax, a BCL-2 inhibitor, synergistically kills the estrogen receptor-positive breast cancer cells. These results suggested that black garlic extract has great therapeutic value and prospects for estrogen receptor-positive breast cancer treatment.

Effectiveness Evaluation Method of Application of Mobile Communication System Based on Factor Analysis.

The application mode of army mobile communication networks is closely related to combat mission and application environment. Different combat missions and application environments result in different network structures and different service priorities, which requires a semi-automatic system to support the network scheme design. Therefore, evaluating the efficiency of network schemes generated by automatic planning is a problem that needs to be urgently addressed. In the past, researchers have proposed a variety of methods to evaluate the effectiveness of mobile communication systems, most of which are based on simulation methods and ignore the historical data of network usage. This paper studies an effectiveness evaluation method of mobile communication network design schemes and proposes a design scheme for the evaluation and optimization of network plans. Furthermore, the improved method of effectiveness evaluation based on factor analysis is discussed in detail. The method not only effectively uses historical data but also reduces the amount of data collection and calculation. In order to adapt to the preference requirements of different task scenarios, a decision preference setting method based on cluster analysis is proposed, which can render the output optimization result more reasonable and feasible.