1.
Chem Pharm Bull (Tokyo)
; 53(7): 743-6, 2005 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15997127
RESUMO
An efficient and highly stereoselective total synthesis of d-biotin has been achieved starting from cis-1,3-dibenzyl-2-imidazolidone-4,5-dicarboxylic acid (2) with an overall yield of 33%. Polymer-supported oxazaborolidine-catalyzed asymmetric reduction of meso-cyclic imide 4 constitutes the key synthetic step in introducing stereogenic centers into the d-biotin molecule.