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BACKGROUND: Vertebroplasty is an effective treatment for osteoporotic vertebral compression fractures (OVCF), but it is nagged by bone cement leakage. OBJECTIVE: To summarize the clinical outcome of modified self-making working tube in percutaneous vertebroplasty (PVP) for treatment of thoracolumbar OVCF. METHODS: Modified PVP working tube was designed to have a lateral gap at the sleeve tail, which could control the cement diffuse direction though rotating the working tube. Totally 121 thoracolumbar OVCF patients were enrolled, including 49 males and 72 females, aged 62-90 years, and then divided into two groups: 59 patients were treated with modified PVP in test group, and the other 62 patients experienced conventional PVP in control group. In the test group, a lateral gap instead of the conventional gap at the sleeve tail was made to control the direction of bone cement injection by rotating the sleeve. The visual analogue scale scores were compared before and after operation; radiographic examination was performed to detect bone cement leakage at 1 day postoperatively. RESULTS AND CONCLUSION: There were significant differences between the preoperative and postoperative visual analogue scale scores in the two groups (P < 0.05), but there was no significant difference between the two groups. There were 3 cases of bone cement leakage in the test group and 10 cases of bone cement leakage in the control group. Modified PVP working tube had significant lower rate of bone cement leakage than traditional PVP(14.9% vs.4.6%,P<0.05).Therefore,the modified PVP working tube is an effective tool to decrease the incidence of bone cement leakage in the treatment of thoracolumbar OVCF.
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AIM: To investigate the risk factors for pregnancy induced hypertension retinopathy, and analyze its influence on maternal and child pregnancy outcomes. METHODS: A total of 100 patients with gestational hypertension who met the requirements of screening were selected, they were divided into two groups, without retinal lesion group (n = 29) and retinopathy group (n=71). The age, course of disease, gestational age, blood pressure, proteinuria and hematocrit in two groups were investigated. The risk factors were detected by single factor analysis, and then the study on independent risk factors were analyzed by Logistic regression analysis. At the same time,their influence on maternal and child pregnancy outcomes were investigated. RESULTS: The single factor analysis showed that except for age, the differences in the course of disease, gestational age, blood pressure, proteinuria and hematocrit were statistically significant (P < 0. 01). Logistic regression analysis showed that the course of disease, blood pressure, proteinuria and hematocrit were the risk factors of retinopathy, gestational age was a protective factor. Compared with the group without retinopathy, the incidence of preterm birth, placental abruption, postpartum hemorrhage, perinatal death in the patients with retinopathy significantly increased, and the difference were statistically significant(P<0.01),and there was a certain correlation between the extent of increase and the grade of retinopathy. CONCLUSION: Course of disease, blood pressure, proteinuria and hematocrit of patients with the hypertension of pregnancy are the risk factors of retinopathy,retinopathy has a serious adverse effect on maternal and child pregnancy outcomes.
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Objective To study the effect ofmethylprednisolone (MP) on the expression of heatshock protein 70 (HSP70) following the injury of spinal cord (SC1) in rats. Methods 125 SD rots wererandomly divided into 5 groups: the simple operation group (n=30), the MP control group (n=30), theinjury group (n=30), the MP treatment group (n=30) and the normal control group (n=5). Specimen of thespinal cord were collected at 2, 6, 12, 24, 48, 72 h after SCI, respectively. Their pathomorphology wasobserved and HSP70 expression was detected by immunohistochemistry. Results After treatment ofMP, the secondary injury was lightened, according to the HE staining of the specimen.lmmunohistochemistry revealed that there were no HSP70 expression in the normal control group and theMP control group, that there was a little HSP70 in the simple operation group, and that there was a lot ofHSP70 in the injury group 2 h after injury, and the expression peaked at 24 h and maintained to 72 h afterinjury. The expression was significantly increased and the peak of expression was in advance in the MPtreatment group as compared with injury group, and it was also found in neuropil of white substance ofspinal cord. Conclusion High-dose NIP can obviously increase the expression of HSP70 in injuredspinal cord, and has the peak time of expression in advance, and enlarge the scope of expression. It maybe one of the mechanism to protect the spinal cord that MP guide myeloid tissue to overexpress HSP70after spinal cord injury.