1.
Org Biomol Chem
; 15(43): 9149-9155, 2017 Nov 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29058746
RESUMO
A formal [3 + 2] annulation of α-bromoenal with monosubstituted hydrazine could give 1,5 or 2,5-difunctionalized 3-pyrazolidinone regiodivergently by tuning the structure of the N-Heterocyclic Carbene (NHC) catalyst. Moderate to high yields, mild reaction conditions, good regioselectivity and potential biological significance of the final product have made this protocol attractive for the assembly of 3-pyrazolidinone.