Diagnosis and treatment of intraductal papillary mucinous neoplasms of the pancreas, report of 16 cases / 中华普通外科杂志

Objective To summarize the experience in the diagnosis and treatment of intraductal papillary mucinous neoplasms (IPMN) of the pancreas.Methods The clinical data of 16 cases of intraductal papillary mucinous neoplasms of the pancreas in the First Affiliated Hospital of China Medical University from January,2000 to October,2013 was retrospectively analyzed.Results There were 9 males and 7 females,age ranging from 37 to 61 years (average 49 years).The common complaint was epigastric pain.Ultrasonography and CT scan found solid lesions in all cases,main pancreatic duct dilatation was found in 10 cases.All the cases received surgical resection of the tumor.Pathology showed adenomas in 14 cases,borderline tumors in one,and adenocarcinoma in one.14 patients were followed-up ranging from 5 to 48 months,all were alive without recurrence and metastasis.Conclusions IPMT is a special type of pancreatic tumor.Surgical resection is the most effective treatment with excellent prognosis.

Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma.

Pancreatic carcinoma is one of the most malignant and aggressive cancers. The identification of prognostic factors is thought to be useful in directing treatment. Transcription factor Jun dimerization protein 2 (JDP2), a member of the activator protein 1 (AP-1) family, acts as an AP-1 inhibitor and has been implicated in many cellular processes including carcinogenesis. The role of JDP2 in the development of pancreatic carcinoma, however, remained elusive. In this study we examined the expression levels of JDP2 in 36 pancreatic carcinoma samples by Western blotting and found that JDP2 expression was significantly downregulated in pancreatic carcinoma samples compared with peritumoral tissues. The decrease in JDP2 expression was correlated with lymph node metastasis and distant metastasis and strongly associated with the post-surgery survival time. These results indicate a possible connection between JDP2 expression and metastasis in pancreatic carcinoma and suggest that JDP2 can serve as a biomarker to predict the prognosis of patients with this cancer.