RESUMO
Scrotal calcinosis (SC) is a rare and benign condition defined as the existence of multiple calcified nodules within scrotal skin. We report the case of a 39-year-old male patient with a three-month history of scrotal tumours that increased rapidly in number and size. Histopathological and immunohistochemical investigations showed no evidence of epithelial structure. Whether SC is idiopathic or the result of the calcification of pre-existing cysts is still a controversial issue. In some cases, as well as in our case, no evidence of cystic structure was found around calcified material, despite minutely careful studies. This suggests that SC might be truly idiopathic.
Assuntos
Calcinose/patologia , Doenças dos Genitais Masculinos/patologia , Adulto , Calcinose/etiologia , Doenças dos Genitais Masculinos/etiologia , Humanos , Masculino , EscrotoRESUMO
The expression pattern of VEGF, p53 and ICAM-1 was studied in conjunctiva of diabetic patients with and without retinopathy. All patients underwent a complete ophthalmic examination, including retinal fluorescein angiography. Indirect immunoperoxidase method was performed on 20 eyes of 20 patients with type II diabetes without DR and on 5 eyes of 5 patients with PDR. A control study was performed on 6 normal conjunctiva undertaken during cataract surgery. Immunoreactivity of VEGF, p53 and ICAM-1 was found in epithelial, fibroblast and vascular endothelial cells. For the same duration of diabetes, a strong to moderate or weak immunoreactivity was observed in the conjunctiva of patients without retinopathy. In patients with PDR, the expression was strong for all these proteins. The immunoreactivity was correlated between VEGF, p53 and ICAM-1. In the normal conjunctiva, a weak to negative immunostaining was observed. The presence of these proteins in the conjunctiva of diabetic patients without retinopathy may add new data in the pathogenesis of diabetic retinopathy. Further studies are needed to confirm this hypothesis.