Multifunctional-hierarchical flexibility metasurfaces for multispectral compatible camouflage of microwave, infrared and visible.

The prevalent use of multispectral detection technology makes single-band camouflage devices ineffective, and the investigation of technology for camouflage that combines multispectral bands becomes urgent. The multifunctional-hierarchical flexibility metasurfaces (MHFM) for multispectral compatible camouflage of microwave, infrared, and visible, is proposed, fabricated, and measured. MHFM is primarily composed of an infrared shielding layer (IRSL), a radar absorbing layer (RAL), and a visible color layer (VCL). Among them, IRSL can block thermal infrared detection, and RAL can efficiently absorb microwave band electromagnetic (EM) waves. The VLC can display black (below 28°C), purple (28°C∼31°C), green (31°C∼33°C), and yellow (above 33°C) at different temperatures to achieve visible camouflage. Simulation results show that MHFM can achieve absorption higher than 90% in the 2.9∼13.9 GHz microwave band. Theoretically, the emissivity of MHFM in the infrared spectral range 3∼14 µm is less than 0.34. In addition, the MHFM consists of high-temperature-resistant materials that can be used normally at temperatures up to 175°C, providing excellent high-temperature stability. The measurement results show that the camouflage performance of the MHFM is in excellent agreement with the proposed theory. This study proposes a new method for multispectral camouflage that has broad engineering applications.

The relationship between typical dreams and mental health of residents in village-in-city.

Aim: This study aimed to explore the relationship between typical dreams and the mental health of residents in village-in-city. Methods: This study used the Chinese version of the Typical Dreams Questionnaire and Symptom Checklist 90 (SCL-90) to investigate the mental health status and typical dream themes of 1,190 residents recruited through random sampling from a village-in-city in Xi'an. Correlation analysis, t-test, and binary regression analysis were performed on the data using SPSS 24.0. Results: The five most frequent dream themes among residents in the village-in-city were "falling"; "school, teacher, study"; "being chased but not physically injured"; "enjoying delicious food"; and "repeatedly trying to do something," in the given order. The most frequent dream theme with negative SCL-90 factors was "falling" and with positive SCL-90 factors was "school, teacher, study." Typical dreams on different themes were significantly correlated with SCL-90 factors. The theme of "enjoying delicious food" was not significantly associated with most factors in SCL-90.

Scalable, Dual-Band Metasurface Array for Electromagnetic Energy Harvesting and Wireless Power Transfer.

A dual-band metasurface array is presented in this paper for electromagnetic (EM) energy harvesting in the Wi-Fi band and Ku band. The array consists of metasurface unit cells, rectifiers, and load resistors. The metasurface units within each column are interconnected to establish two channels of energy delivery, enabling the transmission and aggregation of incident power. At the terminals of two channels, a single series diode rectifier and a voltage doubler rectifier are integrated into them to rectify the energy in the Wi-Fi band and the Ku band, respectively. A 7 × 7 prototype of the metasurface array is fabricated and tested. The measured results in the anechoic chamber show that the RF-to-dc efficiencies of the prototype at 2.4 GHz and 12.6 GHz reach 64% and 55% accordingly, when the available incident power at the surface is 3 dBm and 14 dBm, respectively.

2-tert-Butyl-4-chloro-5-[4-(2-fluoro-eth-oxy)benz-yloxy]pyridazin-3(2H)-one.

In the title compound, C(17)H(20)ClFN(2)O(3), the dihedral angle between the pyridazine and benzene rings is 41.37 (10)°. In the crystal, there are no significant intermolecular interactions present. The terminal -CH(2)F group is disordered over two sets of sites with an occupancy ratio of 0.737 (2):0.263 (2).

Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting.

Three chemical modification methods of carboxymethylation, quaternization and hydroxypropylation were used to synthesize water-soluble chitosan derivatives. In order to study the feasibility of these chitosan derivatives as backbones of nuclear imaging agents, folic acid (FA) and Technetium-99m were introduced onto the water-soluble chitosan chains. The bifunctional chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to the folate grafted chitosan derivatives for chelating with radionuclides such as (64)Cu and (68)Ga. The structures of these new ligands were characterized with multiple methods. The solubility and stability of the (99m)Tc-complexes were both favorable. Further study of their radiochemical and biological properties will be performed to evaluate the usefulness of these water-soluble chitosan derivatives for nuclear imaging agent design.

Radiolabeling of folic acid-modified chitosan with (99m)Tc as potential agents for folate-receptor-mediated targeting.

The feasibility of chitosan (CS) as a backbone for the design of (99m)Tc-labeled targeting agent was evaluated in this study. Chitosan-folate conjugate (CSFA) and chitosan-folate dithiocarbamate (CSFADTC) were synthesized, characterized and radiolabeled with (99m)Tc as model compounds for folate-receptor (FR) targeting. (99m)Tc-complexes were prepared with high radiochemical purity and high stability. The hydrophilicities of these (99m)Tc-complexes were determined by partition coefficient experiments. The results of biodistribution in normal mice showed that the folic-acid modified agents ((99m)Tc-CSFA and (99m)TcN-CSFADTC) had obviously higher uptake in FR-positive kidney and much lower liver and spleen uptakes than that of non-folic-acid modified (99m)Tc-agent, and the kidney uptakes of FA-modified agents could be blocked significantly by the corresponding cold ligand. Furthermore in vitro and in vivo specific studies will be done in cell line and tumor bearing mice to confirm the usefulness of this chitosan backbone for FR targeting agent design.

Fluorine-18 labeled galactosylated chitosan for asialoglycoprotein-receptor-mediated hepatocyte imaging.

Galactosylated chitosan (GC) was prepared by reacting lactobionic acid with water-soluble chitosan. GC was labeled with fluorine-18 by conjugation with N-succinimidyl-4-(18)F-fluorobenzoate ([(18)F]SFB) under a slightly basic condition. After rapid purification with HiTrap desalting column, [(18)F]FB-GC was obtained with high radiochemical purity (>97%) determined by radio-HPLC. The total reaction time for [(18)F]FB-GC was about 150 min. Typical decay-corrected radiochemical yield was about 4-8%. Ex vivo biodistribution in normal mice showed that [(18)F]FB-GC had moderate activity accumulation in liver with very good retention (11.13+/-1.63, 10.97+/-1.90 and 10.77+/-0.95%ID/g at 10, 60, 120 min after injection, respectively). The other tissues except kidney showed relative low radioactivity accumulation. The high liver/background ratio affords promising biological properties to get clear images. The specific binding of this radiotracer to the ASGP receptor was confirmed by blocking experiment in mice. Compared with the non-blocking group the hepatic uptake of [(18)F]FB-GC significantly declined in all selected time points. The better liver retention properties of [(18)F]FB-GC than that of albumin based imaging agents may improve imaging quality and simplify pharmacokinetic model of liver function in the future application with PET imaging.

Preparation and biodistribution of [18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography.

UNLABELLED: Myocardial extractions of pyridaben, a mitochondrial complex I (MC-I) inhibitor, is well correlated with blood flow. Based on the synthesis and characterization of pyridaben analogue 2-tert-butyl-5-[2-(2-[(18)F]fluroethoxy)ethoxy]benzyloxy]-4-chloro-2H-pyridazin-3-one ([(18)F]FP2OP), this study assessed its potential to be developed as myocardial perfusion imaging (MPI) agent. METHODS: The tosylate labeling precursor 2-(2-(4-(tert-butyl-5-chloro-6-oxo-1,6-dihydro-pyridazin-4-yloxymethyl)benzyloxy)ethoxy)ethyl ester (OTs-P2OP) and the nonradioactive 2-tert-butyl-5-[2-(2-[(19)F]fluroethoxy)ethoxy]benzyloxy]-4-chloro-2H-pyridazin-3-one ([(19)F]FP2OP) were synthesized and characterized by IR, (1)H NMR, (13)C NMR and MS analysis. By substituting tosyl of precursor OTs-P2OP with (18)F, the radiolabeled complex [(18)F]FP2OP was prepared and further evaluated for its in vitro physicochemical properties, in vivo biodistribution, the metabolic stability in mice, ex vivo autoradiography and cardiac PET/CT imaging. RESULTS: Starting with [(18)F]F(-) Kryptofix 2.2.2./K(2)CO(3) solution, the total reaction time for [(18)F]FP2OP was about 100 min, with final high-performance liquid chromatography purification included. Typical decay-corrected radiochemical yield stayed at 41+/-5.3%, the radiochemical purity, 98% or more. Biodistribution in mice showed that the heart uptake of [(18)F]FP2OP was 41.90+/-4.52%ID/g at 2 min post-injection time, when the ratio of heart/liver, heart/lung and heart/blood reached 6.83, 9.49 and 35.74, respectively. Lipophilic molecule was further produced by metabolized [(18)F]FP2OP in blood and urine at 30 min. Ex vivo autoradiography demonstrates that [(18)F]FP2OP may have high affinity with MC-I and that can be blocked by [(19)F]FP2OP or rotenone (a known MC-I inhibitor). Cardiac PET images were obtained in a Chinese mini-swine at 5, 15, 30 and 60 min post-injection time with high quality. CONCLUSION: [(18)F]FP2OP was synthesized with high radiochemical yield. The promising biological properties of [(18)F]FP2OP suggest high potential as MPI agent for positron emission tomography in the future.