Language and reading in attention-deficit/hyperactivity disorder and comorbid attention-deficit/hyperactivity disorder + developmental language disorder.

Background: The current study sought to examine whether psycholinguistic assessments could discriminate children and adolescents with developmental language disorder (DLD) from those with attention-deficit/hyperactivity disorder (ADHD; combined or inattentive subtype) and comorbid DLD + ADHD. Methods: The Clinical Evaluation of Language Fundamentals-Screening Test (CELFST; Wiig et al., 2013), the Comprehensive Test of Phonological Processing (nonword repetition subtest; Wagner et al., 2013), and the Test of Word Reading Efficiency (sight word and phonemic decoding subtests; Torgesen et al., 2012) were examined in 441 children and adolescents between 6 and 16 years of age. Results: The presence of a language disorder (with or without ADHD) predicted poor performance across tasks. Children and adolescents with ADHD (combined vs. inattentive) only significantly differed in sight word reading, in favor of those with combined type. Measures of reading efficiency could distinguish between the two types of ADHD, but not between other groups. Interestingly, scores on the standard language screener were no worse for children with ADHD + DLD than children with DLD only. Conclusions: The combination of comorbid ADHD + DLD did not appear to be associated with lower language abilities, sight word reading, or phonemic decoding relative to DLD alone. Reading efficiency was effective in discriminating between ADHD subtypes. These findings offer valuable insights into differential diagnosis and the identification of comorbidity.

Event-related Potential Measures of Visual Word Processing in Monolingual and Bilingual Children and Adults: A Focus on Word Frequency Effects.

How does language background influence the neural correlates of visual word recognition in children? To address this question, we used an ERP lexical decision task to examine first-language (L1) and second-language (L2) visual word processing in monolingual and bilingual school-aged children and young adults (n = 123). In particular, we focused on the effects of word frequency (an index of lexical accessibility) on RTs and the N400 ERP component. Behaviorally, we found larger L1 versus L2 word frequency effects among bilingual children, driven by faster and more accurate responses to higher-frequency words (no other language or age group differences were observed). Neurophysiologically, we found larger L1 word frequency effects in bilinguals versus monolinguals (across both age groups), reflected in more negative ERP amplitudes to lower-frequency words. However, the bilingual groups processed L1 and L2 words similarly, despite lower levels of subjective and objective L2 proficiency. Taken together, our findings suggest that divided L1 experience (but not L2 experience) influences the neural correlates of visual word recognition across childhood and adulthood.

Language abilities in children and adolescents with DLD and ADHD: A scoping review.

PURPOSE: There is an emerging view that attention-deficit/hyperactivity disorder (ADHD) is marked by problems with language difficulties, an idea reinforced by the fact that ADHD is highly comorbid with developmental language disorder (DLD). This scoping review provides an overview of literature on language abilities in children with DLD and ADHD while highlighting similarities and differences. METHOD: A comprehensive search was performed to examine the literature on language abilities in the two disorders, yielding a total of 18 articles that met the inclusion criteria for the present review. Qualitative summaries are provided based on the language domain assessed. RESULTS: The current literature suggests children and adolescents with ADHD have better morphosyntax/grammar, general/core language abilities, receptive, and expressive abilities than those with DLD. Further, that performance is comparable on assessments of semantic and figurative language but varies by sample on assessments of phonological processing, syntax, narrative language, and vocabulary. CONCLUSION: Evidence presented points to children and adolescents with DLD as having greater language difficulties compared to those with ADHD, but with some important caveats. Despite limitations related to the paucity of studies and inconsistencies in how the two types of disorders are identified, our review provides a necessary and vital step in better understanding the language profiles of these two highly prevalent childhood disorders. These findings are useful in optimizing language outcomes and treatment efficacy for children and adolescents with ADHD and DLD.

Learning to Read Strengthens Functional Connectivity Between the Ventral Occipitotemporal Cortex and the Superior Temporal Gyrus During an Auditory Phonological Awareness Task.

PURPOSE: It is often assumed that phonological awareness only reflects children's phonological skill. However, orthographic representations have been found to be automatically involved during phonological awareness tasks, which we refer to as automatic orthographic activation. Although previous longitudinal neural studies have addressed how phonological processing during phonological awareness tasks is bidirectionally related to reading skill in developing children, we do not know how automatic orthographic activation plays a role in reading skill. METHOD: To address this gap, we measured 40 children's reading skill and brain activity during an auditory phonological task at two time points using functional magnetic resonance imaging. Children were 5.5 to 6.5 years old at the first time point and were followed up approximately 1.5 years later when they were 7 to 8 years old. RESULTS: We found that earlier reading skill predicted children's later functional connectivity during onset processing between the left superior temporal gyrus, a phonological region, and the left posterior ventral occipitotemporal cortex, an orthographic region representing letters. CONCLUSION: This finding, together with previous studies, suggests that learning to read influences phonological awareness not only by refining phonological representations but also via strengthening the automatic mapping between phonemes and letters during spoken language processing.

Associations between childhood irritability and neural reactivity to maternal feedback in adolescence.

Early irritability, a transdiagnostic vulnerability for psychopathology, is associated with alterations in neural reactivity to emotional stimuli and reward; however, associations between childhood irritability and neural markers of risk may be mitigated by the quality of caregiving youth receive. We examined longitudinal relationships between irritability in childhood and young adolescents' neural activity of regions typically associated with emotion regulation and reward processing during processing of maternal feedback and tested whether these associations were moderated by youth's perceptions of the parent-child relationship quality. Eighty-one adolescents (Mage = 11.1 years) listened to maternal critical and praising feedback while undergoing functional magnetic resonance imaging. Age 3 irritability, assessed observationally, was negatively associated with age 11 neural reactivity to maternal criticism in a cluster in the right dorsolateral prefrontal cortex (dlPFC), particularly for youths who reported more positive maternal parenting. Given the role of the dlPFC activation in the effortful processing of emotional stimuli, decreased activation may reflect disengagement from negatively valenced interpersonal feedback in the context of a positive caregiving environment, thereby mitigating psychopathology risk associated with irritability.

White matter correlates of reading subskills in children with and without reading disability.

Individual differences in reading ability are associated with characteristics of white matter microstructure in the brain. However, previous studies have largely measured reading as a single construct, resulting in difficulty characterizing the role of structural connectivity in discrete subskills of reading. The present study used diffusion tensor imaging to examine how white matter microstructure, measured by fractional anisotropy (FA), relates to individual differences in reading subskills in children aged 8 to 14 (n = 65). Findings showed positive correlations between FA of the left arcuate fasciculus and measures of single word reading and rapid naming abilities. Negative correlations were observed between FA of the right inferior longitudinal fasciculus and bilateral uncinate fasciculi, and reading subskills, particularly reading comprehension. The results suggest that although reading subskills rely to some extent on shared tracts, there are also distinct characteristics of white matter microstructure supporting different components of reading ability in children.

A sculpting effect of reading on later representational quality of phonology revealed by multi-voxel pattern analysis in young children.

Using univariate analysis, a previous study by Wang et al. (2020) found a scaffolding effect of earlier phonological representation in superior temporal gyrus (STG) on later reading skill but failed to observe a sculpting effect of earlier reading on later phonological representation. The current study applied multi-voxel pattern analysis (MVPA) to examine if both scaffolding and sculpting effects were present in young children. We found that better initial reading skill predicted higher decoding coefficient of brain activity patterns for phonological representations in STG. This sculpting effect was present only for decoding small grain sizes (phonemes) and in younger children (6- to 7.5-year-olds), as we did not find any effects for large grain sizes (rhymes) or older children (7.5- to 9.5-year-olds). Although a scaffolding effect was not observed, the current study provides the first neural evidence of how earlier reading sculpts later phonological awareness in beginning readers.

Developmental changes in the categorization of speech and song.

Music and language are two fundamental forms of human communication. Many studies examine the development of music- and language-specific knowledge, but few studies compare how listeners know they are listening to music or language. Although we readily differentiate these domains, how we distinguish music and language-and especially speech and song- is not obvious. In two studies, we asked how listeners categorize speech and song. Study 1 used online survey data to illustrate that 4- to 17-year-olds and adults have verbalizable distinctions for speech and song. At all ages, listeners described speech and song differences based on acoustic features, but compared with older children, 4- to 7-year-olds more often used volume to describe differences, suggesting that they are still learning to identify the features most useful for differentiating speech from song. Study 2 used a perceptual categorization task to demonstrate that 4-8-year-olds and adults readily categorize speech and song, but this ability improves with age especially for identifying song. Despite generally rating song as more speech-like, 4- and 6-year-olds rated ambiguous speech-song stimuli as more song-like than 8-year-olds and adults. Four acoustic features predicted song ratings: F0 instability, utterance duration, harmonicity, and spectral flux. However, 4- and 6-year-olds' song ratings were better predicted by F0 instability than by harmonicity and utterance duration. These studies characterize how children develop conceptual and perceptual understandings of speech and song and suggest that children under age 8 are still learning what features are important for categorizing utterances as speech or song. RESEARCH HIGHLIGHTS: Children and adults conceptually and perceptually categorize speech and song from age 4. Listeners use F0 instability, harmonicity, spectral flux, and utterance duration to determine whether vocal stimuli sound like song. Acoustic cue weighting changes with age, becoming adult-like at age 8 for perceptual categorization and at age 12 for conceptual differentiation. Young children are still learning to categorize speech and song, which leaves open the possibility that music- and language-specific skills are not so domain-specific.

Responding to parental concern about children's reading.

Objectives: This study explored if parents are accurate in their reading concerns, with implications for paediatric practice. Methods: Parents of school-aged children in 34 schools in Ontario, Canada responded to a questionnaire about their children's academic development (27% response), and their children participated in standardized, norm-referenced tests of word reading and an oral sentence recall task. Parental concern status was retrospectively cross-referenced with reading difficulty status (<25th percentile on the word reading tests) for grade 2 children with complete data (n = 294); diagnostic accuracy was evaluated. Demographic and reading-related characteristics of children whose parents' concern did not match their reading difficulty status were explored. Results: Approximately 22% of parents endorsed concern, while 18.5% of children had word reading difficulty. Parental concern status accurately corresponded with reading difficulty status in 81% of cases (95% CI: 76% to 85%). Specificity was 85% (95% CI: 80% to 90%), while sensitivity was 59% (95% CI: 44% to 73%). Children of unconcerned parents rarely had word reading problems (NPV 91%; 95% CI: 88% to 94%), while children with concerned parents had word reading difficulty in 45% of cases (PPV; 95% CI: 36% to 54%). Apparent inaccuracy (i.e., mismatch between parental concern and reading difficulty status) was related to children's word reading, oral sentence recall skills, and English language learner (ELL) status, but not child age, sex, or parent education. Conclusions: Many parents of grade 2 children endorse reading concerns. Parental concern is an overall accurate screener for word reading difficulty, although some children will be missed. Evidence-informed recommendations for responding to parental concern are provided.

Chinese-English bilinguals are more sensitive to environmental sound perception than Spanish-English bilinguals through top-down cognitive mechanism.

Sensitive perception to environmental sound is important for an individual's daily life since it helps in responding to the environment quickly and avoiding potential risks. It remains unclear, however, whether and how bilingual experiences with different native language backgrounds influence brain responses reflecting environmental sound perception. The present study compared Chinese-English bilinguals, Spanish-English bilinguals, and English monolinguals on their brain response to environmental sound perception and further examined its processing mechanism. The present study did not find the differences between English monolinguals and two bilingual groups on the environmental sound perception. However, we found that compared with Spanish-English bilinguals, Chinese-English bilinguals showed significantly larger mismatch negativity (MMN), indicating that Chinese-English bilinguals were more sensitive to the environmental sounds than that of Spanish-English bilinguals. Further, compared with Spanish-English bilinguals, Chinese-English bilinguals showed significantly larger theta oscillation. In addition, the theta oscillation is significantly correlated with MMN for Chinese-English bilinguals. The results indicated that the advantage of Chinese-English bilingual experience on environmental sound perception may be due to the enhanced top-down cognitive ability. In summary, these findings suggest that compared with the Spanish-English bilinguals, Chinese-English bilinguals showed an advantage in environmental sound perception via enhanced top-down cognitive modulation.

No statistical learning advantage in children over adults: Evidence from behaviour and neural entrainment.

Explicit recognition measures of statistical learning (SL) suggest that children and adults have similar linguistic SL abilities. However, explicit tasks recruit additional cognitive processes that are not directly relevant for SL and may thus underestimate children's true SL capacities. In contrast, implicit tasks and neural measures of SL should be less influenced by explicit, higher-level cognitive abilities and thus may be better suited to capturing developmental differences in SL. Here, we assessed SL to six minutes of an artificial language in English-speaking children (n = 56, 24 females, M = 9.98 years) and adults (n = 44; 31 females, M = 22.97 years), using explicit and implicit behavioural measures and an EEG measure of neural entrainment. With few exceptions, children and adults showed largely similar performance on the behavioural explicit and implicit tasks, replicating prior work. Children and adults also demonstrated robust neural entrainment to both words and syllables, with a similar time course of word-level entrainment, reflecting learning of the hidden word structure. These results demonstrate that children and adults have similar linguistic SL abilities, even when learning is assessed through implicit performance-based and neural measures.

Second Language Immersion Experience Could Help the Brain Response to Second Language Reading for Native Chinese Speakers.

Native language background exerts constraints on the individual's brain automatic response while learning a second language. It remains unclear, however, whether second language immersion experience could help the brain overcome such constraints and meet the requirements of a second language. This study compared native Chinese speakers with English-as-a-second-language immersion experience (immersive English learners), native Chinese speakers without English-as-a-second-language immersion experience (nonimmersive English learners), and native English speakers with an ERP cross-modal MMN paradigm. The results found that English-as-a-second-language immersion could benefit speech perception for native Chinese speakers. In addition, both immersive English learners and native English speakers showed enhanced cross-modal MMN, indicating that second language immersion could help native Chinese speakers successfully integrate English letter-sound like native English speakers. The present study further revealed that English listening and speaking exposure in an immersive environment is important in English letter-sound integration for immersive English learners.

Children's neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression.

Caregiving experiences are implicated in children's depression risk; however, children's neural reactivity to positive and negative feedback from mothers, a potential mediator of depression risk, is poorly understood. In a sample of 81 children (Mage = 11.12 years, SDage = 0.63), some of whom were recruited based on a maternal history of depression (n = 29), we used fMRI to characterize children's neural responses to maternal praise and criticism. Maternal history of depression was unrelated to children's brain activity during both the praise and criticism conditions; however, ROI analyses showed that children's self-reported depressive symptoms were negatively associated with functional activity in the left anterior insula and right putamen while hearing maternal criticism. Whole-brain analyses showed that children's depressive symptoms were positively associated with left inferior frontal gyrus activity while listening to maternal praise. These findings complement past work implicating these brain regions in the processing of emotionally salient stimuli, reward processing, and internal speech. Given associations between early depressive symptoms and later disorder, findings suggest that maladaptive neural processing of maternal feedback may contribute to children's early emerging risk for depression.

Learning unfamiliar words and perceiving non-native vowels in a second language: Insights from eye tracking.

One of the challenges in second-language learning is learning unfamiliar word forms, especially when this involves novel phoneme contrasts. The present study examines how real-time processing of newly-learned words and phonemes in a second language is impacted by the structure of learning (discrimination training) and whether asking participants to complete the same task after a 16-21 h delay favours subsequent word recognition. Specifically, using a visual world eye tracking paradigm, we assessed how English listeners processed newly-learned words containing non-native French front-rounded [y] compared to native-sounding vowels, both immediately after training and the following day. Some learners were forced to discriminate between vowels that are perceptually similar for English listeners, [y]-[u], while others were not. We found significantly better word-level processing on a variety of indices after an overnight delay. We also found that training [y] words paired with [u] words (vs. [y]-Control pairs) led to a greater decrease in reaction times during the word recognition task over the two testing sessions. Discrimination training using perceptually similar sounds had facilitative effects on second language word learning with novel phonemic information, and real-time processing measures such as eyetracking provided valuable insights into how individuals learn words and phonemes in a second language.

Familiarity modulates neural tracking of sung and spoken utterances.

Music is often described in the laboratory and in the classroom as a beneficial tool for memory encoding and retention, with a particularly strong effect when words are sung to familiar compared to unfamiliar melodies. However, the neural mechanisms underlying this memory benefit, especially for benefits related to familiar music are not well understood. The current study examined whether neural tracking of the slow syllable rhythms of speech and song is modulated by melody familiarity. Participants became familiar with twelve novel melodies over four days prior to MEG testing. Neural tracking of the same utterances spoken and sung revealed greater cerebro-acoustic phase coherence for sung compared to spoken utterances, but did not show an effect of familiar melody when stimuli were grouped by their assigned (trained) familiarity. However, when participant's subjective ratings of perceived familiarity were used to group stimuli, a large effect of familiarity was observed. This effect was not specific to song, as it was observed in both sung and spoken utterances. Exploratory analyses revealed some in-session learning of unfamiliar and spoken utterances, with increased neural tracking for untrained stimuli by the end of the MEG testing session. Our results indicate that top-down factors like familiarity are strong modulators of neural tracking for music and language. Participants' neural tracking was related to their perception of familiarity, which was likely driven by a combination of effects from repeated listening, stimulus-specific melodic simplicity, and individual differences. Beyond simply the acoustic features of music, top-down factors built into the music listening experience, like repetition and familiarity, play a large role in the way we attend to and encode information presented in a musical context.

The Task Matters: A Scoping Review on Reading Comprehension Abilities in ADHD.

OBJECTIVE: A broad range of tasks have been used to classify individuals with ADHD with reading comprehension difficulties. However, the inconsistency in the literature warrants a scoping review of current knowledge about the relationship between ADHD diagnosis and reading comprehension ability. METHOD: A comprehensive search strategy was performed to identify relevant articles on the topic. Thirty-four articles met inclusion criteria for the current review. RESULTS: The evidence as a whole suggests reading comprehension is impaired in ADHD. The most prominent effect was found in studies where participants retell or pick out central ideas in stories. On these tasks, participants with ADHD performed consistently worse than typically developing controls. However, some studies found that performance in ADHD improved when reading comprehension task demands were low. CONCLUSION: Results suggest that performance in ADHD depends on the way reading comprehension is measured and further guide future work clarifying why there are such discrepant findings across studies.

Eye Movement Measures of Within-Language and Cross-Language Activation During Reading in Monolingual and Bilingual Children and Adults: A Focus on Neighborhood Density Effects.

We used eye movement measures of first-language (L1) and second-language (L2) paragraph reading to investigate how the activation of multiple lexical candidates, both within and across languages, influences visual word recognition in four different age and language groups: (1) monolingual children; (2) monolingual young adults; (3) bilingual children; and (4) bilingual young adults. More specifically, we focused on within-language and cross-language orthographic neighborhood density effects, while controlling for the potentially confounding effects of orthographic neighborhood frequency. We found facilitatory within-language orthographic neighborhood density effects (i.e., words were easier to process when they had many vs. few orthographic neighbors, evidenced by shorter fixation durations) across the L1 and L2, with larger effects in children vs. adults (especially the bilingual ones) during L1 reading. Similarly, we found facilitatory cross-language neighborhood density effects across the L1 and L2, with no modulatory influence of age or language group. Taken together, our findings suggest that word recognition benefits from the simultaneous activation of visually similar word forms during naturalistic reading, with some evidence of larger effects in children and particularly those whose words may have differentially lower baseline activation levels and/or weaker links between word-related information due to divided language exposure: bilinguals.

Individual differences in representational similarity of first and second languages in the bilingual brain.

Current theories of bilingualism disagree on the extent to which separate brain regions are used to maintain or process one's first and second language. The present study took a novel multivariate approach to address this question. We examined whether bilinguals maintain distinct neural representations of two languages; specifically, we tested whether brain areas that are involved in processing word meaning in either language are reliably representing each language differently, and whether language representation is influenced by individual differences in proficiency level and age of acquisition (AoA) of L2. Thirty-one English-Mandarin bilingual adults performed a picture-word matching task in both languages. We then used representational similarity analysis to examine which brain regions reliably showed different patterns of activity for each language. We found that both proficiency and AoA predicted dissimilarity between language representations in several brain areas within the language network as well as several regions of the ventral visual pathway, demonstrating that top-down language knowledge and individual language experience shapes concept representation in this processing stream. The results support the model of an integrated language system in bilinguals, along with a novel description of how representations for each language change with proficiency level and L2 AoA.

Resting-state functional connectivity and reading subskills in children.

Individual differences in reading ability have been linked to characteristics of functional connectivity in the brain in both children and adults. However, many previous studies have used single or composite measures of reading, leading to difficulty characterizing the role of functional connectivity in discrete subskills of reading. The present study addresses this issue using resting-state fMRI to examine how resting-state functional connectivity (RSFC) related to individual differences in children's reading subskills, including decoding, sight word reading, reading comprehension, and rapid automatized naming (RAN). Findings showed both positive and negative RSFC-behaviour relationships that diverged across different reading subskills. Positive relationships included increasing RSFC among left dorsal and anterior regions with increasing decoding proficiency, and increasing RSFC between the left thalamus and right fusiform gyrus with increasing sight word reading, RAN, and reading comprehension abilities. In contrast, negative relationships suggested greater functional segregation of attentional and reading networks with improved performance on RAN, decoding, and reading comprehension tasks. Importantly, the results suggest that although reading subskills rely to some extent on shared functional networks, there are also distinct functional connections supporting different components of reading ability in children.

Rich-club structure contributes to individual variance of reading skills via feeder connections in children with reading disabilities.

The present work considers how connectome-wide differences in brain organization might distinguish good and poor readers. The connectome comprises a 'rich-club' organization in which a small number of hub regions play a focal role in assisting global communication across the whole brain. Prior work indicates that this rich-club structure is associated with typical and impaired cognitive function although no work so far has examined how this relates to skilled reading or its disorders. Here we investigated the rich-club structure of brain's white matter connectome and its relationship to reading subskills in 64 children with and without reading disabilities. Among three types of white matter connections, the strength of feeder connections that connect hub and non-hub nodes was significantly correlated with word reading efficiency and phonemic decoding. Phonemic decoding was also positively correlated with connectivity between connectome-wide hubs and nodes within the left-hemisphere reading network, as well as the local efficiency of the reading network. Exploratory analyses also identified sex differences indicating these effects were stronger in girls. This work highlights the independent roles of connectome-wide structure and the more narrowly-defined reading network in understanding the neural bases of skilled and impaired reading in children.