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Emerg Infect Dis ; 10(11): 1938-46, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15550203

RESUMO

In countries where bancroftian filariasis is endemic, lymphedema of the leg is a public health problem, particularly for women, who are disproportionately affected. We investigated the effect of basic lymphedema management (hygiene, skin care, and lower limb movement and elevation) on the histologic features of lymphedema. A total of 118 skin-punch biopsy specimens were collected from the legs of 91 patients enrolled in a lymphedema treatment clinic in Léogâne, Haiti. Follow-up biopsy specimens were collected from 27 patients succeeds, equals 12 months later. Keratinocyte hyperproliferation, condensed dermal collagen, and mononuclear perivascular infiltrate increased with lymphedema stage, which suggested progressive chronic inflammation and fibrosis. Follow-up biopsies showed reductions in perivascular mononuclear infiltrate in the superficial dermis (41% decrease in prevalence), perivascular fibrosis in the deep dermis (58% decrease), and periadnexal mononuclear infiltrate (53% decrease). These data suggest that the clinical improvement commonly observed with basic lymphedema management has a histologic basis.


Assuntos
Derme/patologia , Filariose Linfática/patologia , Epiderme/patologia , Tela Subcutânea/patologia , Adolescente , Adulto , Dietilcarbamazina/uso terapêutico , Filariose Linfática/terapia , Feminino , Filaricidas/uso terapêutico , Haiti , Humanos , Masculino , Pessoa de Meia-Idade , Autocuidado
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