RESUMO
Two hundred and ninety-six patients were enrolled in a 6-month, open-label tolerability study of enteric-coated naproxen in patients with rheumatoid arthritis (n = 174) and osteoarthritis (n = 122). Thirty percent of the patients were greater than 65 years of age. Under standard clinical prescribing conditions, enteric-coated naproxen 500 mg twice daily and 375 mg twice daily demonstrated an acceptable tolerability profile that was not different from what one would expect with standard naproxen.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Naproxeno/uso terapêutico , Osteoartrite/tratamento farmacológico , Adulto , Fatores Etários , Idoso , Esquema de Medicação , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Naproxeno/efeitos adversos , Comprimidos com Revestimento EntéricoRESUMO
A survey of first-year medical students at the University of Toronto shows that academic factors are viewed as the most stressful and social factors as the least stressful. Among anticipated sources of stress those dealing with perceived failure are highly stressful, and those dealing with sexual aspects of the doctor-patient relationship are much less so. Factor analysis reveals that sources of stress are multidimensional rather than unidimensional. Particular socio-demographic antecedent variables are much more highly correlated with stress than are others. In particular, it is found that students in subgroups differing from "mainstream" students feel more stress than their mainstream counterparts. Feelings of stress are also found to be positively related to possible consequences of stress, such as frequency of thinking about dropping out and to number of days off school because of illness.