Resilience, innovation and collapse of settlement networks in later Bronze Age Europe: New survey data from the southern Carpathian Basin.

Societies of the later Early to Middle Bronze Age (ca. 2200-1600 BC) in the Carpathian Basin exhibited complex, hierarchical and regionally influential socio-political organisation that came to an abrupt end in the 16th century BC. Considered a collapse by some, this change was characterised by abandonment of virtually all central places / nodes in settlement networks. Until recently, the complexity that characterised the period was believed to have substantially diminished alongside depopulation. This model was reinforced by a combination of the loss of established external networks and low-resolution knowledge of where and how people lived in the first stages of the Late Bronze Age (between 1600 and 1200 BC). We contest the idea of a diminished Late Bronze Age and argue that a fully opposite trajectory can be identified-increased scale, complexity and density in settlement systems and intensification of long-distance networks. We present results of a settlement survey in the southern Pannonian Plain using remote and pedestrian prospection, augmented by small-scale excavations. New absolute dates are used to define the occupational history of sites dating primarily between 1500-1200 BC. We argue that climate change played a substantial role in in the transformation of settlement networks, creating a particular ecological niche enabling societies to thrive. New and specific forms of landscape exploitation developed that were characterised by proximity to wetlands and minor watercourses. In this context, the largest monuments of Bronze Age Europe were created and inhabited. In considering the origins and demise of these megasites and related settlements, we provide a new model for Late Bronze Age societies in the Carpathian Basin and their regional relevance.

The influence of traffic-infrastructure factors on pedestrian accidents at the macro-level: The geographically weighted regression approach.

INTRODUCTION: Walking is an active way of moving the population, but in recent years there have been more pedestrian casualties in traffic, especially in developing countries such as Serbia. Macro-level road safety studies enable the identification of influential factors that play an important role in creating pedestrian safety policies. METHOD: This study analyzes the impact of traffic and infrastructure characteristics on pedestrian accidents at the level of traffic analysis zones. The study applied a geographically weighted regression approach to identify and localize all factors that contribute to the occurrence of pedestrian accidents. Taking into account the spatial correlations between the zones and the frequency distribution of accidents, the geographically Poisson weighted model showed the best predictive performance. RESULTS: This model showed 10 statistically significant factors influencing pedestrian accidents. In addition to exposure measures, a positive relationship with pedestrian accidents was identified in the length of state roads (class I), the length of unclassified streets, as well as the number of bus stops, parking spaces, and object units. However, a negative relationship was recorded with the total length of the street network and the total length of state roads passing through the analyzed area. CONCLUSION: These results indicate the importance of determining the categorization and function of roads in places where pedestrian flows are pronounced, as well as the perception of pedestrian safety near bus stops and parking spaces. PRACTICAL APPLICATIONS: The results of this study can help traffic safety engineers and managers plan infrastructure measures for future pedestrian safety planning and management in order to reduce pedestrian casualties and increase their physical activity.

Effectiveness of implementing a Graduated Driver Licensing (GDL) law among young Serbian drivers.

INTRODUCTION: Young novice drivers have higher rates of engagement in road crashes worldwide, often owing to unfavorable attitudes toward road safety or lack of knowledge, experience, and risk consciousness. However, the implementation of graduated driver licensing (GDL) systems has proven effective in reducing the high incidence of young drivers involved in crashes. METHOD: The purpose of this study was to compare the change in driving outcomes (e.g., attitudes toward traffic safety, behavior patterns while driving, risk assessment in traffic, assessment of personal driving skills, and involvement in traffic crashes) of young drivers prior to and following the implementation of a GDL law. Respondents (n = 642) completed a battery of questions, including a driver attitudes questionnaire (Behaviour of Young Novice Drivers Scale), a self-assessed driving ability questionnaire, and a risk perception questionnaire. Of the total sample size, 324 drivers passed the old system of training driver's license candidates, and 318 drivers passed the new GDL system. RESULTS: The results showed that drivers licensed with GDL reported safer attitudes toward traffic rule violations and speed, and higher levels of safety orientation with regard to their driving abilities. They also reported much higher levels of risk perception and lower exposure to risky situations (risky driving exposure). There were no differences between GDL drivers and non-GDL drivers in terms of self-reported crashes or transient or fixed violations. In addition, GDL was not related to the number of traffic crashes, the number of fatalities, or serious and slight injuries in crashes involving young drivers in crashes obtained from official records. CONCLUSIONS: The results suggest that GDL contributed to the improvement of drivers' attitudes and understanding of risk but did not contribute to significant changes in the behavior of young drivers and traffic crashes. In addition, the GDL program in Serbia only ranks fair on the Insurance Institute for Highway Safety (IIHS) scale. Strengthening the GDL program in Serbia with additional components in line with GDL programs rated as good by the IIHS scale could improve the safety of young and novice drivers in traffic.

Differences in Driving Anger among Professional Drivers: A Cross-Cultural Study.

Public transport systems have a vital role in achieving sustainable mobility goals, diminishing reliance on private individual transport and improving overall public health. Despite that, transport operators are often in situations that require them to cope with complex working conditions that lead to negative emotions such as anger. The current study represents a segment of the permanent global research agenda that seeks to devise and test a psychometric scale for measuring driving anger in professional drivers. The present research is one of the first attempts to examine the factorial validity and the cross-cultural measurement equivalence of the broadly utilized Driving Anger Scale (DAS) in three culturally different countries within the Western Balkans region. The respondents (N = 1054) were taxi, bus and truck drivers between 19 and 75 years of age. The results pertaining to confirmatory factor analysis showed that there were adequate fit statistics for the specified six-dimensional measurement model of the DAS. The measurement invariance testing showed that the meaning and psychometric performance of driving anger and its facets are equivalent across countries and types of professional drivers. Furthermore, the results showed that driving anger facets had positive correlations with dysfunctional ways of expressing anger and negative correlations with the form of the prosocial anger expression. In addition, the results revealed that taxi drivers displayed considerably higher levels of anger while driving and aggressive driving than truck and bus drivers. Overall, this study replicates and extends the accumulated knowledge of previous investigations, suggesting that the original DAS remains a reliable and stable instrument for measuring driving anger in day-to-day driving conditions.

Procedure for the Selection of Rubber Compound in Rubber-Metal Springs for Vibration Isolation.

The selection of a rubber compound has a determining influence on the final characteristics of rubber-metal springs. Therefore, the correct selection of a rubber compound is a key factor for development of rubber-metal vibration isolation springs with required characteristics. The procedure for the selection of the rubber compound for vibration isolation of rubber-metal springs has been proposed, so that the rubber-metal elements have the necessary characteristics, especially in terms of deflection. The procedure is based on numerical simulation of spring deflection with Bergström-Boyce constitutive model in virtual experiment, with a goal to determine which parameters of the constitutive model will lead to spring required deflection. The procedure was verified by case study defined to select rubber compound for a rubber-metal spring used in railway engineering.

The influence of driving anger on truck drivers' speeding behavior in Serbia: the evidence from naturalistic global positioning system driving data.

OBJECTIVE: Speeding behavior is recognized as one of the three main causes of risk on the roads and the most frequent ordinary violation among truck drivers. The study reported in this article focused on the driving anger personality trait and its role in predicting the observed speeding behavior in a sample of truck drivers. METHODS: A longitudinal study design was implemented, where 93 Serbian truck drivers filled in an adapted form of the Driving Anger Scale designed to assess the amount of driving anger evoked by specific traffic situations. The drivers' second-by-second speeding behavior data were captured using GPS tracking and recording devices installed in the vehicles over a period of six months. Hierarchical multiple linear regression was used to examine the predictive performance of driving anger. RESULTS: The results showed that more than three fourths of the exceeded speed ranged from 1 to 9 km/h and the highest percentage of speed events occurred in urban areas. The findings suggest that truck drivers experienced the highest level of anger in driving because of the discourteous and illegal behavior of other drivers. Younger truck drivers are more likely to drive fast compared to older drivers. Truck drivers who perform driving tasks more often and spend less time driving are more likely to participate in speed events. The results revealed that the subscales of anger, hostile gestures and traffic obstructions have a positive effect, while slow driving has a negative effect on the observed speeding behavior of truck drivers. CONCLUSIONS: This study confirms the predictive performance of driving anger facets. The results of the research can help us improve our understanding of the mechanisms of speeding behavior of truck drivers.

Driving anger and factors related to aggressive driving among Serbian drivers.

Objective: Driving anger has been found to be a motivational determinant of risky and aggressive driving. The study reported in this article focused on research questions concerning the conceptualization of driving anger and relationships between driving anger and aggressive driving.Methods: In a cross-sectional survey study, 1,020 regular Serbian drivers completed a web-based online questionnaire. Exploratory Factor Analysis and Confirmatory Factor Analysis were used to assess the factor structure and psychometric properties of the Driving Anger Scale.Results: The results showed that the adapted DAS was a valid and reliable instrument divided into five subscales such as discourteous behavior, illegal behavior, slow driving, hostile gestures and traffic obstructions. The robustness of the five-factor model obtained from the EFA was confirmed by the CFA. The study provided evidence supporting the predictive validity of the adapted DAS and revealed that the dimensions of driving anger are differently associated with prosocial and aggressive driving behaviors.Conclusions: The study supports the adapted DAS validity and produces evidence that driving anger is associated with driving outcomes.

Perception of health-related case studies in the context of introduction to clinical medicine course: students' and teachers' perspective.

BACKGROUND: Integrating theoretical and practical knowledge and stimulating students' active learning is the most important task of modern and high-quality healthcare education. By analyzing clinical cases, undergraduate medical students are trained to make accurate diagnoses, to choose appropriate therapy based on laboratory results and on adequate diagnostic tests. AIM: To examine the effect of clinical cases presentations on short-term memory as well as on the student's and teachers' evaluation of this method of teaching and learning in undergraduate medical studies. METHODS: A total of 107 students in term 4 and term 5 enrolled in Trinity Medical Sciences University in St. Vincent and the Grenadines participated in this cross-sectional study. At the end of the semester, the students and the faculty were asked to complete a survey to assess their perception of case presentations (10 items, 4-point Likert-type scale, strongly agree to strongly disagree). The results of pre- and post-presentation quizzes were evaluated using the Wilcoxon signed rank test for paired samples. RESULTS: Term 4 and term 5 students significantly improved their achievement after intervention (Wilcoxon test Z = - 11.282, p < 0.001, and Wilcoxon test Z = - 10.167, p < 0.001, respectively). The analysis of progress among low- and high-performance students in both terms showed a significant increase in performance. Overall, median students' and teachers' attitude scores were positive. CONCLUSION: Clinical case presentation has a learning potential and facilitates positive interaction between instructors and students and supporting students to become reflective and competent physicians.

Macro-level accident modeling in Novi Sad: A spatial regression approach.

In this study, a macroscopic analysis was conducted in order to identify the factors which have an effect on traffic accidents in traffic analysis zones. The factors that impact accidents vary according to the characteristics of the observed area, which in turn leads to a discrepancy between research and practice. The total number of accidents was observed in this paper, along with the number of motorized and non-motorized mode accidents within a three-year period in the city of Novi Sad. The models used for this analysis were spatial predictive models comprised of the classical predictive space model, spatial lag model and spatial error model. The spatial lag model showed the best performances concerning the total number of accidents and number of motorized mode accidents, whereas the spatial error model was prominent within the number of non-motorized mode accidents. The results found that increasing Daily Vehicle-Kilometers Traveled, parking spaces, 5-legged intersections and signalized intersections increased all types of accidents. The other demographic, traffic, road and environment characteristics showed that they had a different effect on the observed types of accidents. The results of this research can be benefitial to reserachers who deal with traffic engineering, space planning as well as making decisions with the aim of preparing countermeasures necessary for road safety improvement in the analysed area.

The effect of age and compression strength on venous leg ulcer healing.

Objectives The aim of the study is to compare proportions of venous leg ulcers healed in patients treated with two different sub-bandage pressure values in relation to age. Methods The study included 102 outpatients with venous leg ulcers, one group with moderate compression pressure of 35-40 mmHg and the second with high pressure >45 mmHg. Each group was divided into two subgroups according to the age (≥65 vs. <65 years). Computerized planimetry was used to measure the size of the ulcers at 6, 12, 18 and 24 weeks. Results Kaplan-Maier analysis showed high pressure leads to higher proportion of healed venous leg ulcers, compared to moderate pressure, in patients aged ≥65 years (57.6% vs. 28%) and in patients <65 years (53.8% vs. 36%) (p < 0.05). Conclusion The study showed that higher compression pressure leads to higher proportions of venous leg ulcers healed, independent of age and could be safely preferred in older patients.

Immunohistochemical distribution of Ki67 in epidermis of thick glabrous skin of human digits.

The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67. Immunohistochemical distribution of Ki67 was confined to basal and suprabasal layers, with pattern of distribution specific for intermediate, limiting and transverse ridges that gradually transform within epidermal height. Deep epidermal ridges, interdigitating with dermal papillae, participate in construction of intricate epidermal base, whose possible role in epidermal regeneration was also discussed. Having a prominent morphology, this type of epidermis offers the best morphological insight in complexities of skin organization, and its understanding could challenge and improve currently accepted models of epidermal organization.

The impact of police presence on angry and aggressive driving.

An extensive body of research has found that angry and aggressive driving are both significantly related to crash involvement. There has also been a large body of research investigating the situational factors related to angry and aggressive driving, but one interesting question that has not yet been answered is whether the enforcement of traffic laws causes or reduces angry and aggressive driving. The independent region of Northern Kosovo represents a unique opportunity to investigate the impact of a lack of traffic enforcement on driving behaviour. Therefore, the present study set out to investigate whether the presence of traffic enforcement has a significant impact on the level of driver anger and aggressive driving. Registered owners of motor vehicles in Northern Kosovo and Serbia were both sent a questionnaire which contained the 28-item Dula Dangerous Driving Index (DDDI) and the 21-item UK Driving Anger Scale (UKDAS). This found that anger was higher in two of the four driving anger factors (direct hostility and progress impeded) and two of the three DDDI factors (risky driving & aggressive driving). Furthermore, the present study found that the lack of police enforcement was a significant predictor of both aggressive and risky driving, even after the driving anger and demographic variables had been partialled out. Therefore, it appears that introducing or increasing traffic enforcement may be one method of reducing aggressive and risky driving behaviour.

An examination of the construct and predictive validity of the self-reported speeding behavior model.

The present study deals with the problem of speeding behavior on rural roads. The purpose of the paper is to examine the construct validity and the internal consistency and reliability of a questionnaire that measures the determinants of speeding behavior. In addition, it aimed to test the predictive validity of a modified theoretical framework of a theory of planned behavior (TPB) in relation to speeding behavior. A total of 546 car drivers from five local communities in the Republic of Srpska successfully completed the questionnaire after reading the scenario. The principal component analysis revealed seven components interpreted as: personal norm, perceived behavioral control, affective attitude toward speeding, subjective norm, habit, descriptive norm, and cognitive attitude toward speeding. A speeding behavior model was developed by structural equation modeling. Personal norm, subjective norm, and affective attitudes were shown to be important variables within the modified TPB in understanding speeding behavior. Overall, the present findings provide significant support for the concept of the modified theoretical framework of TPB in relation to speeding behavior on rural roads. Implications for a speeding behavior model and interventions are discussed.

Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers.

BACKGROUND/AIM: Kidney injury molecule-1 (KIM-1) and aquaporin-1 (AQP-1) are potential early urinary biomarkers of clear renal cell carcinoma (cRCC). The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy) in patients with cRCC. METHODS: Urinary concentrations of urinary KIM-1 (uKIM-1) and urinary AQP-1 (uAQP-1) were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. RESULTS: The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ? 1.120 ng/mg urinary creatinine (Ucr)] were significantly greater compared with controls (healthy volunteers) (0.210 +/- 0.082 ng/mgUcr) (p = 0.0227). Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 +/- 0.099 ng/mgUcr vs 0.210 + 0.082 ng/mgUcr, respectively). The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 +/- 0.092 ng/mgUcr) compared with the control group (0.202 +/- 0.078 ng/mgUcr) (p = 0.0014). Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. CONCLUSION: uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy.

Acquired cystic disease and renal cell carcinoma in hemodialysis patients--A case report on three patients.

INTRODUCTION: Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and represents approximately 3.8% of all malignancies in adults. The incidence of renal cell carcinoma has been growing steadily and ranging from 0.6 to 14.7 for every 100,000 inhabitants. Patients with end-stage renal disease and acquired cystic kidney disease are at increased risk of developing RCC while undergoing dialysis treatment or after renal transplantation. CASE REPORT: We presented 3 patients undergoing hemodialysis, with acquired cystic kidney disease accompanied by the development of RCC. In all the patients tumor was asymptomatic and discovered through ultrasound screening in 2 patients and in 1 of the patients by post-surgery pathohistological analysis of the tissue of the kidney excised using nephrectomy. All the three patients had organ-limited disease at the time of the diagnosis and they did not require additional therapy after surgical treatment. During the follow-up after nephrectomy from 6 months to 7 years, local recurrence or metastasis of RCC were not diagnosed. CONCLUSION: Acquired cystic kidney disease represents a predisposing factor for the development of renal cell carcinoma in dialysis patients and requires regular ultrasound examinations of the abdomen aimed at early diagnosis of malignancies. Prognosis for patients with end-stage renal disease and RCC is mostly good because these tumors are usually of indolent course.

Specificities of transplantation of kidneys procured from donors with situs inversus totalis--a case report and review of the literature.

INTRODUCTION: Situs inversus totalis (SIT) represents a total vertical transposition of the thoracic and abdominal organs which are arranged in a mirror image reversal of the normal positioning. We presented a successful pre-dialysis kidney transplantation from a living sibling donor with SIT and the longest donor follow-up period, along with analysis of the reviewed literature. CASE REPORT: The pair for pre-dialysis kidney transplantation included a 68-year-old mother and 34-year-old daughter at low immunological risk. Comorbid- ities evidenced in kidney donors with previously diagnosed SIT, included moderate arterial hypertension and borderline blood glucose level. Explantation of the left donor kidney and its placement into the right iliac fossa of the recipient were performed in the course of the surgical procedure. A month after nephrectomy, second degree renal failure was noticed in the donor. A 20-month follow-up of the donor's kidney and graft in the recipient proved that their functions were excellent. CONCLUSION: In donors with previously di- agnosed SIT the multidisciplinary approach, preoperative evaluation of the patient and detection of possible vascular anomalies are required to provide maximum safety for the donor.

Kidney failure as an unusual initial presentation of biclonal gammopathy (IgD multiple myeloma associated with light chain disease)--a case report.

INTRODUCTION: Immunoglobulin D (IgD) myeloma is a rare disease, about 2% of all myelomas, even rarer when accompanied with another multiple myeloma in biclonal gammopathy. We presented a case of biclonal gammopathy-as-sociated manifestation of IgD myeloma and light chain disease in a patient who initially had renal failure. CASE REPORT: 37-year-old male approximately one month before hospitalization began to feel malaise and fatigue along with decreased urination. Laboratory analysis revealed azotemia. A dialysis catheter was placed and hemodialysis started. The patient was then admitted to our hospital for further tests and during admission, objective examination revealed pronounced paleness with hepatosplenomegaly and hypertension (170/95 mmHg). Laboratory analysis showed erythrocyte sedimentation rate 122 mm/h, expressed anemic syndrome (Hb 71 g/L) and renal failure dialysis rank: creatinine 1,408 micromol/L, urea 31.7 mmol/L. There was two M components in serum protein electrophoresis: IgD lambda and free light chain lambda. Proteinuria was nephrotic rank (5.4 g/24 h), whose electrophoresis revealed 2 M components--massive in alpha 2 fraction of 71%; 7% in the discrete beta fraction, beta 2M / serum 110 mg / L, in urine 1.8 mg/L--extremely high; IgL kappa I lambda index 1:13 (reference value ratio 2:1). The findings pointed to double myeloma disease: IgD myeloma and Bence Jones lambda myeloma. Bone biopsy confirmed IgD myeloma lambda 100% infiltration medulla predominantly plasmablasts. The treatment continued with hemodialysis 3 times per week with chemotherapy protocol bortezomib, doxorubicin, dexamethasone. After 4 cycles of chemotherapy, there was a decrease of IgD, lamda-light chains, reduction in proteinuria (1.03 g/24 h), so hemodialysis was reduced to once per week. Six months after treatment initiation the patient underwent autologous bone marrow transplantation. In a 2-year follow-up period double myeloma disease showed complete remission. CONCLUSION: The presented rare form of double myeloma disease with initial renal insufficiency underscores the importance of careful observation and teamwork that can alter the course of this serious disease.

Mobile telephones: a comparison of radiated power between 3G VoIP calls and 3G VoCS calls.

The purpose of this study is to assess the mean RF power radiated by mobile telephones during voice calls in 3G VoIP (Voice over Internet Protocol) using an application well known to mobile Internet users, and to compare it with the mean power radiated during voice calls in 3G VoCS (Voice over Circuit Switch) on a traditional network. Knowing that the specific absorption rate (SAR) is proportional to the mean radiated power, the user's exposure could be clearly identified at the same time. Three 3G (High Speed Packet Access) smartphones from three different manufacturers, all dual-band for GSM (900 MHz, 1800 MHz) and dual-band for UMTS (900 MHz, 1950 MHz), were used between 28 July and 04 August 2011 in Paris (France) to make 220 two-minute calls on a mobile telephone network with national coverage. The places where the calls were made were selected in such a way as to describe the whole range of usage situations of the mobile telephone. The measuring equipment, called "SYRPOM", recorded the radiation power levels and the frequency bands used during the calls with a sampling rate of 20,000 per second. In the framework of this study, the mean normalised power radiated by a telephone in 3G VoIP calls was evaluated at 0.75% maximum power of the smartphone, compared with 0.22% in 3G VoCS calls. The very low average power levels associated with use of 3G devices with VoIP or VoCS support the view that RF exposure resulting from their use is far from exceeding the basic restrictions of current exposure limits in terms of SAR.

The relationship between the travelling speed and motorcycle styles in urban settings: a case study in Belgrade.

This report examines the difference in the distribution of the speeds of different motorcycle styles and the difference in the distribution of speeds of particular motorcycle styles and cars. The relationship between the speed of motorcycles that possess and those that do not possess vehicle registration plates was also explored. The speed was measured at six different locations on main roads in the city of Belgrade, Serbia. The study confirmed that, on average, motorcyclists drive faster than drivers of cars, but extreme speeding is recorded 2.3 times more often by motorcyclists than by car drivers. In this research, the styles of motorcycles were divided into three different groups according to their average speeds. The first group consists of sport motorcycles, which were faster than the other styles. The second group consists of scooter motorcycles, which were slower. The third group consists of conventional, touring, enduro, and chopper motorcycles with speeds that were statistically not significantly different. According to the differences of the mean speed of motorcyclists who use and do not use vehicle registration plates, the use of the registration plates can be considered a significant indicator of traffic safety. By classifying motorcycles in the three different groups, the issue of "generalizing" motorcyclists as a unique group is avoided and can be taken into consideration for future studies of motorcyclist safety.