RESUMO
Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1-->2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Dissacarídeos/uso terapêutico , Edema/tratamento farmacológico , Quercetina/análogos & derivados , Acetato de Tetradecanoilforbol/toxicidade , Animais , Dissacarídeos/química , Edema/induzido quimicamente , Feminino , Camundongos , Quercetina/química , Quercetina/uso terapêutico , Acetato de Tetradecanoilforbol/administração & dosagemRESUMO
Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.