Specialised Teachers' Perceptions on the Management of Aggressive Behaviours in Children and Adolescents with Autism Spectrum Disorders.

This study aimed to explore and describe the perception of specialized teachers regarding the management of aggressive behaviors in children and adolescents with autism spectrum disorders. Data were collected from 13 specialized teachers working in primary and secondary schools, using focus group interviews, and interview data were analyzed using an open coding method. The analysis of the specialized teachers' perceptions of the management of aggression in children and adolescents with autism revealed the following results. A central theme "consistent practices to smooth edges" was conceptualized along with the categories: educational responses to individual behaviors, which had sub-themes of "identification of aggressive behavior patterns" and "strategic responses to aggressive behaviors observed"; experience in interventions for aggressive behaviors, with sub-themes of "individual intervention practices" and "school-led therapeutic support" and "factors preventing mitigation of aggression"; and acceptance of virtual reality (VR) based intervention model for aggression, with sub-themes of "acceptance of VR-based program applications" and "proposal for VR-based program contents." Based on the specialized teachers' perceptions examined in this study, more effective education and training intervention programs and support systems can be developed and provided for the management of aggressive behaviors in children and adolescents with autism.

The relationship between a disposition of gratitude, clinical stress, and clinical satisfaction in nursing students.

PURPOSE: This study assessed a disposition of gratitude, and clinical practice stress and satisfaction in nursing students, to determine the relationship between them and provide some basic information towards improving their satisfaction with clinical practice. DESIGN AND METHODS: This descriptive research was conducted on 171 nursing students from three universities in South Korea using a structured questionnaire. FINDINGS: Students who had a stronger disposition of gratitude (t = 3.482; P < .001), lower clinical practice stress (t = -2.998; P < .003), and better health (t = 2.900; P < .004) were more satisfied with their Clinical practice (R2 = 0.298; F = 13.853; P < .001). PRACTICE IMPLICATIONS: The findings emphasized the development of programs to improve disposition of gratitude in curriculum or extracurricular activity to enhance Clinical practice satisfaction.

Information Completeness and Consistency of Inpatient Fall-Event Reports.

Reporting system need to correctly classify information about adverse clinical management events to develop preventative and corrective strategies. We investigated the completeness and consistency of the data, collected using the fall-event reporting system of a hospital, to understand the strengths and weaknesses of the current system.

Effectiveness of gratitude disposition promotion program on depression and quality of life of chronic schizophrenic patients.

CONTEXT: Gratitude intervention is expectedly an effective intervention to reduce depression and improve the quality of life in schizophrenic patients, but there is a lack of literature on it. AIMS: We attempted to develop and test the effectiveness of the gratitude disposition promotion program for chronic schizophrenic patients in Korea. SETTINGS AND DESIGN: Nonequivalent control group pre- and post-test design was used in two mental health centers located at Gyeonggi-do in South Korea. MATERIALS AND METHODS: This paper was a quasi-experimental study and the participants who took part in the gratitude disposition promotion program were 17 of experimental group and 15 of control group. Gratitude disposition (the short gratitude, resentment, and appreciation test), depression (Beck Depression Inventory), and quality of life (developed by Kook) of chronic schizophrenic patients were measured before and after an intervention, as compared to the control. STATISTICAL ANALYSIS: Chi-square test, Fisher's exact test, and t-test were performed for prehomogeneity testing for variables related to the general characteristics. Testing for the effectiveness of gratitude disposition promotion program and hypothesis testing for its effect on depression and quality of life were by ANCOVA and t-test, as verified to significance level of P < 0.05. RESULTS: The participants who received the gratitude disposition promotion program showed significant improvements in gratitude disposition (F = 18.740, P < 0.0001) and in quality of life (F = 9.800, P = 0.004), but no significant difference in depression (F = 3.870, P = 0.059). CONCLUSIONS: The gratitude disposition promotion program was an effective clinical intervention program for enhancing gratitude disposition and quality of life of chronic schizophrenic patients in community.

Comparing Inpatient Falls Guidelines to Develop an ICNP.

This study compared and synthesized clinical guidelines for inpatient falls with the aim of developing an ICNP®-based nursing catalogue for use in electronic nursing records. The identified content will influence nursing services provided to patients and the associated documentation.

Humidifier Disinfectants Are a Cause of Lung Injury among Adults in South Korea: A Community-Based Case-Control Study.

BACKGROUNDS: An outbreak of lung injury among South Korean adults was examined in a hospital-based case-control study, and the suspected cause was exposure to humidifier disinfectant (HD). However, a case-control study with community-dwelling controls was needed to validate the previous study's findings, and to confirm the exposure-response relationship between HD and lung injury. METHODS: Each case of lung injury was matched with four community-dwelling controls, according to age (±3 years), sex, residence, and history of childbirth since 2006 (for women). Environmental risk factors, which included type and use of humidifier and HD, were investigated using a structured questionnaire during August 2011. The exposure to HD was calculated for both cases and controls, and the corresponding risks of lung injury were compared. RESULTS: Among 28 eligible cases, 16 patients agreed to participate, and 60 matched controls were considered eligible for this study. The cases were more likely to have been exposed to HD (odds ratio: 116.1, 95% confidence interval: 6.5-2,063.7). All cases were exposed to HDs containing polyhexamethyleneguanidine phosphate, and the risk of lung injury increased with the cumulative exposure, duration of exposure, and exposure per day. CONCLUSIONS: This study revealed a statistically significant exposure-response relationship between HD and lung injury. Therefore, continuous monitoring and stricter evaluation of environmental chemicals' safety should be conducted.

HOXB5 induces invasion and migration through direct transcriptional up-regulation of ß-catenin in human gastric carcinoma.

HOX (homeobox) genes encode a family of transcriptional regulators, which have an important role in morphogenesis and differentiation during embryonic development. Their deregulated expression is involved in the carcinogenesis of many human solid tumours. In the present study, we show that HOXB5 mRNA was significantly overexpressed in gastric cancer tissues compared with adjacent normal tissues. HOXB5-up-regulated cancer cells showed increased invasion and migration activity, but no change in proliferation activity, whereas HOXB5-down-regulated cells showed decreased invasion and migration activity. Up-regulation of HOXB5 resulted in up-regulation of ß-catenin, whereas inhibition of HOXB5 expression by siRNA led to the down-regulation of ß-catenin. Moreover, a significant correlation between HOXB5 and CTNNB1 (ß-catenin) mRNA expression was detected in gastric cancer tissues. Furthermore, we found that HOXB5 binds directly to the CTNNB1 promoter region and activates the transcriptional expression of ß-catenin, as well as its downstream target genes, encoding cyclin D1 and c-Myc, leading to an increase in the invasion and migration activity of human gastric cancer cells. Thus HOXB5 may be an important regulator of the Wnt/ß-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis.

Antilisterial Effect of Bacteriocin SH01, Obtained from Enterococcus faecium SH01, in Ground Beef.

From the previous study, Enterococcus faecium SH01 was isolated from mukeunji, an over-ripened kimchi, and it produced bacteriocin SH01. Bacteriocin SH01 showed an inhibitory effect against Listeria monocytogenes ATCC 19111, a bacterial strain causing human listeriosis. Crude bacteriocin SH01 was purified by ammonium sulfate precipitation and its inhibitory activity at two concentrations (500 and 1,000 AU/g) against Listeria monocytogenes ATCC 19111 was investigated in ground beef at increasing temperatures (5, 10, 15, and 20℃) for 8 d. The number of Listeria monocytogenes ATCC 19111 significantly decreased (p<0.05) as the concentration of bacteriocin increased from 500 to 1,000 AU/g. Intrinsic crude protease activities in ground beef were examined and increased as the temperature increased. Experiments varying both the concentrations of added bacteriocin SH01 and temperature demonstrated a maximum inhibition (2.33 log reduction of bacteria) in samples containing 1,000 AU/g of bacteriocin SH01 incubated at 20℃. When the crude bacteriocin SH01 solution (1,280 AU/mL) was incubated with crude protease solutions at different temperatures, its activity decreased by only half (640 AU/mL), as assessed in an agar well diffusion assay. The finding that the antilisterial activity of bacteriocin SH01 increased with temperature can be explained by the fact that higher temperatures increase bacterial membrane fluidity, thereby promoting the cellular penetration of bacteriocin SH01 into L. monocytogenes. Bacteriocin SH01 may be an excellent candidate as a biopreservative for controlling L. monocytogenes growth in ground beef.

Thymosin ß4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/ß-catenin signaling pathway.

Thymosin ß4 (Tß4) is a 43-amino-acid peptide involved in many biological processes. However, the precise molecular signaling mechanism(s) of Tß4 in cell invasion and migration remain unclear. In this study, we show that Tß4 was significantly overexpressed in colorectal cancer tissues compared to adjacent normal tissues and high levels of Tß4 were correlated with stage of colorectal cancer, and that Tß4 expression was associated with morphogenesis and EMT. Tß4-upregulated cancer cells showed increased adhesion, invasion and migration activity, whereas Tß4-downregulated cells showed decreased activities. We also demonstrated that Tß4 interacts with ILK, which promoted the phosphorylation and activation of AKT, the phosphorylation and inactivation of GSK3ß, the expression and nuclear localization of ß-catenin, and integrin receptor activation. These results suggest that Tß4 is an important regulator of the ILK/AKT/ß-catenin/Integrin signaling cascade to induce cell invasion and migration in colorectal cancer cells, and is a potential target for cancer treatment.

A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation.

BACKGROUND: In April 2011 a tertiary hospital in Seoul, Korea reported several cases of severe respiratory distress of unknown origin in young adults. METHODS: To find the route of transmission, causative agent and patient risk factors of the outbreak, an investigation of the epidemic was initiated. Clinicopathological conferences led to the suspicion that the cases related to an inhalation injury. An age- and sex-matched case-control study was therefore performed to examine the inhalation exposure of the patients to various agents. RESULTS: Of the 28 confirmed cases, 18 agreed to participate. A total of 121 age- and sex-matched controls with pulmonary, allergic or obstetric disease were selected. All patients and controls completed questionnaires with questions about exposure to various inhalants. The crude ORs for patient exposure to indoor mould, humidifier use, humidifier detergent use and insecticide use were 4.4 (95% CI 1.5 to 13.1), 13.7 (95% CI 1.8 to 106.3), 47.3 (95% CI 6.1 to 369.7) and 3.9 (95% CI 1.3 to 11.7), respectively. However, when considered concurrently, indoor mould and insecticide use lost statistical significance. Moreover, humidifier use was ruled out as the cause because of a lack of biological plausibility and the weak strength of the association. This suggested that humidifier disinfectant was the cause of the outbreak. This information led the Korean government to order the removal of humidifier detergents from the market. In the years following the ban, no additional cases were detected. CONCLUSIONS: Epidemiological evidence strongly suggests that the lung injury outbreak was caused by humidifier detergent use at home.

A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome.

BACKGROUND: Over a few months in the spring of 2011, a cluster of patients with severe respiratory distress were admitted to our intensive care unit (ICU). Household clustering was also observed. Extensive laboratory investigations failed to detect an infectious cause. METHODS: Clinical, radiological and pathological investigations were conducted and the Korean Center for Disease Control performed epidemiological studies. RESULTS: The case series consisted of 17 patients. Their median age was 35 (range 28-49) years. Six were pregnant at presentation and four had given birth 2 weeks previously. All presented with cough and dyspnoea. In the majority of patients (14/17), multifocal areas of patchy consolidation were identified in the lower lung zones on the initial CT. As the condition progressed, the patchy consolidation disappeared (10/13) and diffuse centrilobular ground-glass opacity nodules started to predominate and persist. Pathological specimens (11/17) showed a bronchiolocentric, temporally homogenous, acute lung injury pattern with sparing of the subpleural and peripheral alveolar areas. Ten patients required mechanical ventilation, eight of whom subsequently received extracorporeal life support. Four of the latter underwent lung transplantation. Five of the six patients in the ICU who did not receive lung transplantation died. An epidemiological investigation revealed that all patients had used humidifier disinfectants in their homes. CONCLUSIONS: This case series report showed that lung injury and respiratory failure can occur as a result of inhaling humidifier disinfectants. This emphasises the need for more stringent safety regulations for potentially toxic inhalants that might be encountered in the home.