Efficacy of Baishao Luoshi decoction on synaptic plasticity in rats with post stroke spasticity.

OBJECTIVE: To evaluate the efficacy of Baishao Luoshi decoction (, BD) on synaptic plasticity in rats with post stroke spasticity (PSS), and to study the mechanism behind the action. METHODS: The PSS model of rat was established by middle cerebral artery occlusion (MCAO). The neurological deficit symptoms were evaluated by modified neurological deficit score (mNSS). Muscle tension were evaluated by Modified Ashworth score (MAS). Transmission electron microscopy (TEM) was used to observe the synaptic ultrastructure. The expression of synaptic plasticity-related protein brain derived neurotrophic factor (BDNF), growth associated protein-43 (GAP43), synaptophysin (p38) and microtubule-associated protein 2 (MAP2) in the brain tissue around the infarct were detected by Western blotting. RESULTS: We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD. The thickness of postsynaptic density and the synaptic curvature increased significantly. The expression of synaptic plasticity-related protein BDNF, GAP43, p38, MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD. CONCLUSIONS: Alleviating PSS by BD may be related to rescuing the synaptic plasticity, which provides a probable new therapeutic method for PSS.

Investigation on quantitative diagnosis of stroke with Qi deficiency and blood stasis / 国际中医中药杂志

Objective To build diagnostic model of stroke with qi deficiency and blood stasis.Methods Get the disease information by epidemiological investigation. All patients were recurited into training samples and testing samples by random. Diagnostic model was built by statistical method, and tested by training samples and testing samples. Results Three diagnostic models were built. The best model with discriminant function of qi deficiency and blood stasis has been proven to be the Bayes model. Conclusion The diagnostic model built by epidemiological investigation has the advantage of good accuracy. It will improve the accuracy of clinical syndrome differentiation.

Practice and Experience of Problem-base Learning Teaching in Pharmacology / 中华医学教育探索杂志

The article introduces characteristics of problem-based learning teaching method and traditionary medical teaching method,analyzes the current status and practical importance of pharmacology teaching with PBL,and suggests promoting the development of the teaching of pharmacology with PBL by reforming teaching approach and altering teaching thought.

The Analysis and the Evaluation on the Examination Paper of Pharmacology for Seven-year System Medical students / 中华医学教育探索杂志

It showed that the distribution of examination score was Gaussian distribution,the average score was 74.4,the paper reliability was 0.81,the difficult coefficient was 0.74 by analyzing and evaluating the quality of the examination paper of pharmacology from 2002 seven-year medical students in Central South University.Some objective questions are too difficult,while some subjective questions are too easy.According to the results of analysis,we think it better to culture the student's multi-ability in analyzing and solving questions by increasing the proportion of subjective question with some difficult coefficient and improving the teaching methods in future teaching.