Could Belief in Fake News Predict Vaccination Behavior in the Elderly?

Willingness to get a vaccine was important during the COVID-19 pandemic. Previous studies suggest that vaccine hesitation during the pandemic could have been related to truth discernment, belief in information, exposure to misinformation, attitudes to vaccines, and conspiracy beliefs. Previous studies were mostly with younger adults, and studies with older adults are lacking. This study aimed to analyze the relationship between the trust or belief in fake online news (print news was not included), truth discernment, attitudes, and willingness to be vaccinated during the COVID-19 pandemic while controlling for some significant factors/variables that could affect vaccination in a sample of older adults. There were 504 pre-retirees and retirees participating in this study. Participants from Lithuania age ranged from 50 to 90 years old (M = 64.37, SD = 9.10), 58.3 percent were females. Results from several path models predicting the participants willingness to get a vaccine suggested that stronger conspiracy beliefs and skeptical attitudes toward vaccination would be related to lower willingness to get vaccinated. Participants who disbelieved in the headlines were already vaccinated. Therefore, it seems that discernment (the ability to distinguish which information is true and which is not) is not related to the willingness to vaccinate.

Responses at Individual Gamma Frequencies Are Related to the Processing Speed but Not the Inhibitory Control.

The link between the state of networks underlying the generation of periodic responses at gamma ranges and cognitive outcomes is still poorly understood. In this study, we tested the idea that the individual differences in the ability to generate responses to auditory stimulation at gamma frequencies may underlie the individual differences in the inhibitory control. We focused on the processing speed and accuracy in the Bivalent Shape Task (a cognitive inhibition task assessing attentional interference) and explored the relationship with responses at 40 Hz and at individual gamma frequencies (IGFs, assessed utilizing auditory envelope-following responses in 30-60 Hz range). In a sample of 70 subjects, we show that individual measures (phase-locking index and event-related spectral perturbation) of the ability to generate gamma-range activity are not related to the individual differences in inhibitory control but rather reflect basic information processing speed in healthy young subjects. With the individualized approach (at IGFs), the observed associations were found to be somewhat stronger. These findings have important implications for the interpretation of gamma activity in neuropsychiatric disorders.

Individual Resonant Frequencies at Low-Gamma Range and Cognitive Processing Speed.

Brain electrophysiological activity within the low gamma frequencies (30-80 Hz) has been proposed to reflect information encoding and transfer processes. The 40-Hz auditory steady-state response (40-Hz ASSR) is frequently discussed in relation to changed cognitive processing in neuropsychiatric disorders. However, the relationship between ASSRs and cognitive functioning still remains unclear. Most of the studies assessed the single frequency ASSR, while the individual resonance frequency in the gamma range (30-60 Hz), also called individual gamma frequency (IGF), has received limited attention thus far. Nevertheless, IGF potentially might better reflect individual network characteristics than standardly utilized 40-Hz ASSRs. Here, we focused on the processing speed across different types of cognitive tasks and explored its relationship with responses at 40 Hz and at IGFs in an attempt to uncover how IGFs relate to certain aspects of cognitive functioning. We show that gamma activity is related to the performance speed on complex cognitive task tapping planning and problem solving, both when responses at 40 Hz and at IGFs were evaluated. With the individualized approach, the observed associations were found to be somewhat stronger, and the association seemed to primarily reflect individual differences in higher-order cognitive processing. These findings have important implications for the interpretation of gamma activity in neuropsychiatric disorders.

40-Hz auditory steady-state responses and the complex information processing: An exploratory study in healthy young males.

Electroencephalographic (EEG) activity in the gamma (30-80 Hz) range is related to a variety of sensory and cognitive processes which are frequently impaired in schizophrenia. Auditory steady-state response at 40-Hz (40-Hz ASSR) is utilized as an index of gamma activity and is proposed as a biomarker of schizophrenia. Nevertheless, the link between ASSRs and cognitive functions is not clear. This study explores a possible relationship between the performance on cognitive tasks and the 40-Hz ASSRs in a controlled uniform sample of young healthy males, as age and sex may have complex influence on ASSRs. Twenty-eight young healthy male volunteers participated (mean age ± SD 25.8±3.3) in the study. The 40-Hz click trains (500 ms) were presented 150 times with an inter-stimulus interval set at 700-1000 ms. The phase-locking index (PLI) and event-related power perturbation (ERSP) of the ASSR were calculated in the 200-500 ms latency range, which corresponds to the steady part of the response. The Psychology Experiment Building Language (PEBL) task battery was used to assess five cognitive subdomains: the Choice response time task, the Stroop test, the Tower of London test, the Lexical decision task and the Semantic categorisation task. Pearson's correlation coefficients were calculated to access the relationships; no multiple-test correction was applied as the tests were explorative in nature. A significant positive correlation was observed for the late-latency gamma and the mean number of steps in the Tower of London task reflecting planning and problem-solving abilities. These findings support the concept that 40-Hz ASSR might highlight top-down mechanisms which are related to cognitive functioning. Therefore, 40-Hz ASSRs can be used to explore the relationship between cognitive functioning and neurophysiological indices of brain activity.

Preoperative verbal memory problems and their clinical prognostic value in meningioma patients: A prospective study.

This study aimed to evaluate clinical utility of The Hopkins Verbal Learning Test-Revised (HVLT-R) for assessment of preoperative memory function in meningioma patients and to investigate prognostic value of memory assessment in predicting outcomes after meningioma excision surgery. A total of 93 meningioma patients were assessed 2-3 days preoperatively using HVLT-R, and EORTC QLQ-30 and QLQ-BN20. Functional outcome at discharge was evaluated using The Glasgow Outcome Scale. A sample of 95 healthy controls was matched to patients according to age, gender, and education. Meningioma patients demonstrated impaired working memory, delayed recall and recognition, flatter learning slope, and less effective acquisition. Location of meningioma was not related to any of the studied memory scores. Patients with left sided meningiomas more often produced false positive recognitions and demonstrated worse delayed recall when compared to patients with right sided, but not bilateral meningiomas. Verbal memory impairment was not associated with perceived health status. Functional outcome at discharge was predicted by tumor side, global health status score, and HVLT-R Cumulative learning score. Cumulative verbal learning impairment was associated with greater risk for poor functional outcome, indicating that cognitive impairment has added prognostic value beyond established prognostic indicators of meningioma patients.