RESUMO
Intrauterine growth restriction (IUGR) has been identified as a risk factor for adult chronic kidney disease (CKD), including hypertension (HTN). Accelerated postnatal catch-up growth superimposed to IUGR has been shown to further increase the risk of CKD and HTN. Although the impact of excessive postnatal growth without previous IUGR is less clear, excessive postnatal overfeeding in experimental animals shows a strong impact on the risk of CKD and HTN in adulthood. On the other hand, food restriction in the postnatal period seems to have a protective effect on CKD programming. All these effects are mediated at least partially by the activation of the renin-angiotensin system, leptin and neuropeptide Y (NPY) signaling and profibrotic pathways. Early nutrition, especially in the postnatal period has a significant impact on the risk of CKD and HTN at adulthood and should receive specific attention in the prevention of CKD and HTN.
Assuntos
Retardo do Crescimento Fetal/fisiopatologia , Hipertensão/prevenção & controle , Fenômenos Fisiológicos da Nutrição do Lactente/fisiologia , Estado Nutricional/fisiologia , Insuficiência Renal Crônica/prevenção & controle , Animais , Desenvolvimento Infantil/fisiologia , Modelos Animais de Doenças , Humanos , Hipertensão/epidemiologia , Hipertensão/etiologia , Hipertensão/fisiopatologia , Recém-Nascido de Baixo Peso/fisiologia , Recém-Nascido , Leptina/metabolismo , Redes e Vias Metabólicas/fisiologia , Neuropeptídeo Y/metabolismo , Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/etiologia , Insuficiência Renal Crônica/fisiopatologia , Sistema Renina-Angiotensina/fisiologiaRESUMO
Monkeys were trained to perform isometric plantar flexions of the foot in a simple reaction time situation. In test sessions, the contralateral hindlimb area of the motor cortex was cooled by a cryode placed on the dura until somatosensory evoked potentials disappeared. Movement amplitude decreased to about 70% of initial size; reaction time which was measured on the EMG, and torque signals increased slightly; and the evoked response in the dentate nucleus of the cerebellum remained unchanged. An extensive lesion in the motor cortex by coagulation reduced the movement amplitude to 10% of its preoperational size, but again, did not change reaction time significantly. It is concluded that the motor cortex is not essential for the execution of this overtrained simple movement.