Coincidence of hereditary angioedema (HAE) with Crohn's disease.

A patient with two diseases, based presumably on different immunopathological mechanisms, hereditary angioedema (HAE) and Crohn's disease, was followed for 8 years. For more than three years of this observation period, detailed laboratory data were also available and could be analyzed. Both diseases had severe courses requiring chronic treatment with danazol and sulfasalazine, respectively. During exacerbation of Crohn's disease, the levels of C4 was found to be significantly lower than during the periods free of symptoms of both diseases. This drop was probably due to an impaired C1-inhibitor activity. HAE attacks and acute exacerbation of Crohn's disease never occurred simultaneously. This finding may be a mere chance but may also indicate that the different immunopathological processes underlying HAE and Crohn's disease influence each other.

[Simultaneous occurrence of hereditary angioneurotic edema and Crohn disease]. / Hereditaer angioneuroticus oedema és Crohn-betegség együttes elöfordulása.

Hereditary C1 esterase inhibitor deficiency is often associated with immunpathologic disorders. The authors present a case of the rare coincidence of hereditary angioedema (HAE) and Crohn's disease. The history of the patient is analysed along with the familial occurrence of the disease. Characteristic abdominal manifestations of C1 esterase inhibitor deficiency are compared to the clinical signs of Crohn's disease. Differential diagnostic pitfalls are described along with efficatious therapeutic options.

[Effect of fibroscopic sclerotherapy of hemorrhaging esophageal varices on survival in alcoholic liver cirrhosis (comparative retrospective study)]. / Nyelöcsö visszérrepedésböl eredö vérzés fiberoszkópos szklerotizáló kezelésének hatása a túlélésre alkoholos eredetú mäjcirrhosisban (Osszehasonlító, retrospektív tanulmány).

UNLABELLED: Between 1983 and 1992 altogether 638 alcoholic cirrhotic patients had been treated because of acute esophageal variceal bleeding. In 96 cases the treatment were carried out in the following circumstances; volume and coagulation factor substituate, vasopressin or glypressin and nitroglycerin, urgent endoscopy and ballontamponade but in 47 cases an urgent sclerotherapy were also performed. The survival, cases of rebleeding,-from the first bleeding events-of the 49 nonsclerosed patients were compared to those of the 47 sclerosed one. CONCLUSIONS: 1. The endoscopic sclerotherapy proved to be life-saving procedure. 2. Within 30 days the nonsclerosed patients died twice as much number than the slcerosed patients. 3. The lengths of the survival period were found four and half times so long at the sclerosed patients than in nonsclerosed patients (535 versus 125 days). 4. The numbers of the rebleeding were not less at the sclerosed patients than the nonsclerosed subjects. 5. The lengths of the nonbleeding period was found triple so long at the sclerosed patients than in nonsclerosed patients. 6. The survival of the "Child C" patients at the sclerosed and nonsclerosed patients, too. The authors come to conclusion that by the fiberendoscopic sclerotherapy an increase in the survival time of the patients with acute esophageal variceal bleeding in alcoholic cirrhosis can be achieved.