RESUMO
BACKGROUND: We report a rare case of Mammalian orthoreovirus (MRV) infection in a child with a primary immunodeficiency (PID). Infections with Mammalian orthoreovirus are very rare and probably of zoonotic origin. Only a few cases have been described so far, including one with similar pathogenesis as in our case. CASE PRESENTATION: The patient, age 11, presented with flu-like symptoms and persistent severe diarrhea. Enterovirus has been detected over several months, however, exact typing of a positive cell culture remained inconclusive. Unbiased metagenomic sequencing then detected MRV in stool samples from several time points. The sequencing approach further revealed co-infection with a recombinant Coxsackievirus and Adenovirus. MRV-specific antibodies detected by immunofluorescence proved that the patient seroconverted. CONCLUSION: This case highlights the potential of unbiased metagenomic sequencing in supplementing routine diagnostic methods, especially in situations of chronic infection with multiple viruses as seen here in an immunocompromised host. The origin, transmission routes and implications of MRV infection in humans merit further investigation.
Assuntos
Infecções por Adenoviridae/virologia , Infecções por Coxsackievirus/virologia , Síndromes de Imunodeficiência/complicações , Metagenômica/métodos , Infecções por Reoviridae/virologia , Infecções por Adenoviridae/etiologia , Criança , Coinfecção , Infecções por Coxsackievirus/etiologia , Diarreia/virologia , Enterovirus/genética , Enterovirus/patogenicidade , Infecções por Enterovirus/virologia , Feminino , Humanos , Síndromes de Imunodeficiência/virologia , Orthoreovirus de Mamíferos/genética , Orthoreovirus de Mamíferos/patogenicidade , Infecções por Reoviridae/etiologiaRESUMO
We present a detailed study of vortex-core spectroscopy in slightly overdoped Bi2Sr2CaCu2O8+delta using a low-temperature scanning tunneling microscope. Inside the vortex core, we observe a fourfold symmetric modulation of the local density of states with an energy-independent period of (4.3 +/- 0.3)a0. Furthermore, we demonstrate that this square modulation is related to the vortex-core states which are located at +/-6 meV. Since the core-state energy is proportional to the superconducting gap magnitude , our results strongly suggest the existence of a direct relation between the superconducting state and the local electronic modulations in the vortex core.
RESUMO
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
