RESUMO
The purpose of the study was to investigate the evolution of the tissue metabolism parameters in the course of the treatment of aggressive periodontitis forms. MATERIALS AND METHODS: The paper presents the results of the treatment of 68 patients with chronic generalized periodontitis. The control group comprised 10 healthy individuals. The patients of groups 1 and 3 were treated with metronidazole placement into gingival pockets; those of groups 2 and 4 received a mixture of metronidazole and Eplan. General therapy of group 1 and 2 included treatment with Calcemin, while that of group 3 and 4 alendronate and alphacalcidolum based medicine. Treatment efficiency was assessed by clinical signs, alkaline phosphatase level activity in the oral fluid, as well as serum levels of general and a ionized calcium, phosphorous, alkaline phosphatase and and osteocalcin. RESULTS: The test results before treatment showed higher level of the alkaline phosphatase and osteocalcin in the blood of the patients with periodontitis vs. controls. In the course of follow up group 4 patients showed a clinical response already on the 3rd day of treatment, activization of osteogenesis and bone tissue mineralization in 3 months, and a recovery of the bone metabolism markers in 12 months after local application of Eplan and intake of alendronate and alphacalcidolum based medicine. CONCLUSION: The proposed therapy using Eplan and alendronate and alphacalcidolum based medicines increases the efficiency of periodontitis therapy, which allows for a faster relief of inflammation of periodontal tissues, bone tissue mineralization, long-term and sustainable disease regression.