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1.
Phys Rev E ; 109(1-1): 014305, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38366444

RESUMO

In this study, the stochastic properties of player and team ball possession times in professional football matches are examined. Data analysis shows that player possession time follows a gamma distribution and the player count of a team possession event follows a mixture of two geometric distributions. We propose a formula for expressing team possession time in terms of player possession time and player count in a team's possession, verifying its validity through data analysis. Furthermore, we calculate an approximate form of the distribution of team possession time and study its asymptotic property.

2.
J Biomed Opt ; 29(1): 016006, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-38239389

RESUMO

Significance: We present a motion-resistant three-wavelength spatial frequency domain imaging (SFDI) system with ambient light suppression using an 8-tap complementary metal-oxide semiconductor (CMOS) image sensor (CIS) developed at Shizuoka University. The system addresses limitations in conventional SFDI systems, enabling reliable measurements in challenging imaging scenarios that are closer to real-world conditions. Aim: Our study demonstrates a three-wavelength SFDI system based on an 8-tap CIS. We demonstrate and evaluate the system's capability of mitigating motion artifacts and ambient light bias through tissue phantom reflectance experiments and in vivo volar forearm experiments. Approach: We incorporated the Hilbert transform to reduce the required number of projected patterns per wavelength from three to two per spatial frequency. The 8-tap image sensor has eight charge storage diodes per pixel; therefore, simultaneous image acquisition of eight images based on multi-exposure is possible. Taking advantage of this feature, the sensor simultaneously acquires images for planar illumination, sinusoidal pattern projection at three wavelengths, and ambient light. The ambient light bias is eliminated by subtracting the ambient light image from the others. Motion artifacts are suppressed by reducing the exposure and projection time for each pattern while maintaining sufficient signal levels by repeating the exposure. The system is compared to a conventional SFDI system in tissue phantom experiments and then in vivo measurements of human volar forearms. Results: The 8-tap image sensor-based SFDI system achieved an acquisition rate of 9.4 frame sets per second, with three repeated exposures during each accumulation period. The diffuse reflectance maps of three different tissue phantoms using the conventional SFDI system and the 8-tap image sensor-based SFDI system showed good agreement except for high scattering phantoms. For the in vivo volar forearm measurements, our system successfully measured total hemoglobin concentration, tissue oxygen saturation, and reduced scattering coefficient maps of the subject during motion (16.5 cm/s) and under ambient light (28.9 lx), exhibiting fewer motion artifacts compared with the conventional SFDI. Conclusions: We demonstrated the potential for motion-resistant three-wavelength SFDI system with ambient light suppression using an 8-tap CIS.


Assuntos
Diagnóstico por Imagem , Antebraço , Humanos , Diagnóstico por Imagem/métodos , Imagens de Fantasmas , Antebraço/diagnóstico por imagem , Iluminação
3.
Sensors (Basel) ; 23(23)2023 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-38067704

RESUMO

In this paper, we present a prototype pseudo-direct time-of-flight (ToF) CMOS image sensor, achieving high distance accuracy, precision, and robustness to multipath interference. An indirect ToF (iToF)-based image sensor, which enables high spatial resolution, is used to acquire temporal compressed signals in the charge domain. Whole received light waveforms, like those acquired with conventional direct ToF (dToF) image sensors, can be obtained after image reconstruction based on compressive sensing. Therefore, this method has the advantages of both dToF and iToF depth image sensors, such as high resolution, high accuracy, immunity to multipath interference, and the absence of motion artifacts. Additionally, two approaches to refine the depth resolution are explained: (1) the introduction of a sub-time window; and (2) oversampling in image reconstruction and quadratic fitting in the depth calculation. Experimental results show the separation of two reflections 40 cm apart under multipath interference conditions and a significant improvement in distance precision down to around 1 cm. Point cloud map videos demonstrate the improvements in depth resolution and accuracy. These results suggest that the proposed method could be a promising approach for virtually implementing dToF imaging suitable for challenging environments with multipath interference.

4.
Sensors (Basel) ; 23(8)2023 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-37112329

RESUMO

This paper presents a time-of-flight image sensor based on 8-Tap P-N junction demodulator (PND) pixels, which is designed for hybrid-type short-pulse (SP)-based ToF measurements under strong ambient light. The 8-tap demodulator implemented with multiple p-n junctions used for modulating the electric potential to transfer photoelectrons to eight charge-sensing nodes and charge drains has an advantage of high-speed demodulation in large photosensitive areas. The ToF image sensor implemented using 0.11 µm CIS technology, consisting of an 120 (H) × 60 (V) image array of the 8-tap PND pixels, successfully works with eight consecutive time-gating windows with the gating width of 10 ns and demonstrates for the first time that long-range (>10 m) ToF measurements under high ambient light are realized using single-frame signals only, which is essential for motion-artifact-free ToF measurements. This paper also presents an improved depth-adaptive time-gating-number assignment (DATA) technique for extending the depth range while having ambient-light canceling capability and a nonlinearity error correction technique. By applying these techniques to the implemented image sensor chip, hybrid-type single-frame ToF measurements with depth precision of maximally 16.4 cm (1.4% of the maximum range) and the maximum non-linearity error of 0.6% for the full-scale depth range of 1.0-11.5 m and operations under direct-sunlight-level ambient light (80 klux) have been realized. The depth linearity achieved in this work is 2.5 times better than that of the state-of-the-art 4-tap hybrid-type ToF image sensor.

5.
Sensors (Basel) ; 22(7)2022 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-35408057

RESUMO

Multi-path interference causes depth errors in indirect time-of-flight (ToF) cameras. In this paper, resolving multi-path interference caused by surface reflections using a multi-tap macro-pixel computational CMOS image sensor is demonstrated. The imaging area is implemented by an array of macro-pixels composed of four subpixels embodied by a four-tap lateral electric field charge modulator (LEFM). This sensor can simultaneously acquire 16 images for different temporal shutters. This method can reproduce more than 16 images based on compressive sensing with multi-frequency shutters and sub-clock shifting. In simulations, an object was placed 16 m away from the sensor, and the depth of an interference object was varied from 1 to 32 m in 1 m steps. The two reflections were separated in two stages: coarse estimation based on a compressive sensing solver and refinement by a nonlinear search to investigate the potential of our sensor. Relative standard deviation (precision) and relative mean error (accuracy) were evaluated under the influence of photon shot noise. The proposed method was verified using a prototype multi-tap macro-pixel computational CMOS image sensor in single-path and dual-path situations. In the experiment, an acrylic plate was placed 1 m or 2 m and a mirror 9.3 m from the sensor.

6.
Sensors (Basel) ; 22(5)2022 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-35271100

RESUMO

An ultra-high-speed computational CMOS image sensor with a burst frame rate of 303 megaframes per second, which is the fastest among the solid-state image sensors, to our knowledge, is demonstrated. This image sensor is compatible with ordinary single-aperture lenses and can operate in dual modes, such as single-event filming mode or multi-exposure imaging mode, by reconfiguring the number of exposure cycles. To realize this frame rate, the charge modulator drivers were adequately designed to suppress the peak driving current taking advantage of the operational constraint of the multi-tap charge modulator. The pixel array is composed of macropixels with 2 × 2 4-tap subpixels. Because temporal compressive sensing is performed in the charge domain without any analog circuit, ultrafast frame rates, small pixel size, low noise, and low power consumption are achieved. In the experiments, single-event imaging of plasma emission in laser processing and multi-exposure transient imaging of light reflections to extend the depth range and to decompose multiple reflections for time-of-flight (TOF) depth imaging with a compression ratio of 8× were demonstrated. Time-resolved images similar to those obtained by the direct-type TOF were reproduced in a single shot, while the charge modulator for the indirect TOF was utilized.

7.
Opt Express ; 29(23): 38324-38336, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34808887

RESUMO

This study aimed to achieve high range precision in the sub-100 µm order with time-of-flight (TOF) range imaging for 3-D scanners. The precision of a TOF range imager was improved using dual reference plane sampling (DRPS). DRPS using two short-pulse lasers reduces driver jitter, which limits the range precision below sub-100 µm. A proof-of-concept measurement system implemented using a TOF range imager demonstrated the reduction in driver jitters, resulting in reduced column-to-column variation in range precision. The developed system also achieved a high precision of 52 µm using a single frame and 27 µm using a 10-frame average.

8.
J Biomed Opt ; 26(8)2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34387050

RESUMO

SIGNIFICANCE: Spatial frequency domain imaging (SFDI) is a wide-field imaging technique that provides quantitative maps of tissue optical properties. We describe a compact SFDI imager that employs a multispectral compound-eye camera. This design enables simultaneous image acquisition at multiple wavelengths. Such a device has potential for application for quantitative evaluation of superficial tissues by nonspecialists in low-resource settings. AIM: The aim of this work was to develop a compact SFDI imager for widefield imaging of in-vivo tissue optical properties and verify its ability to measure optical properties of tissue-simulating phantoms and in a preclinical model of burn wounds. APPROACH: This compound-eye imager was constructed using a CMOS sensor subdivided into multiple regions, each having a bandpass filter and objective lens. The ability of the instrument to image optical properties was compared with (1) a commercial SFDI imager and (2) a laboratory-based system. Initial validation of ability to accurately characterize optical properties was performed using a tissue-simulating optical phantom. It was then applied to an established murine model of thermal contact burn severity. In-vivo measurements of the optical properties of rat skin were performed before and after the application of burns. Histology was used to verify burn severity. RESULTS: Measurements of the tissue-simulating phantom optical properties made using the compound-eye imager agree with measurements made using the two comparison SFDI devices. For the murine burn model, the burns showed a decrease in the reduced scattering coefficient at all measurement wavelengths compared with preburn measurements at the same locations. This is consistent with previously reported changes in scattering that occur in full-thickness burns. CONCLUSION: We demonstrate the potential for SFDI to be translated into compact form factor using a compound-eye camera that is capable of obtaining multiple wavelengths channels simultaneously.


Assuntos
Queimaduras , Imagem Óptica , Animais , Queimaduras/diagnóstico por imagem , Estudos de Viabilidade , Camundongos , Imagens de Fantasmas , Ratos , Pele/diagnóstico por imagem
9.
Sensors (Basel) ; 21(2)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33440663

RESUMO

This paper presents a high-linearity high-resolution time-of-flight (ToF) linear-array digital image sensor using a time-domain negative feedback technique. A coarse ToF measurement loop uses a 5-bit digital-to-time converter (DTC) and a delayed gating-pulse generator for time-domain feedback to find the zero of the difference between ToF and the digital estimate of the gating-pulse delay while maintaining a constant operating point of the analog readout circuits. A fine ToF measurement uses a delta-sigma modulation (DSM) loop using the time-domain feedback with a bit-stream signal form. Because of the self-contained property of the DSM for low distortion and noise exploited by the oversampling signal processing, the proposed technique provides high-linearity and high-range resolution in the fine ToF measurement. A prototype ToF sensor of 16.8 × 16.8 µm2 two-tap pixels and fabricated in a 0.11 µm (1P4M) CMOS image sensors (CIS) process achieves +0.9%/-0.47% maximum nonlinearity error and a resolution of 0.24 mm (median) for the measurement range of 0-1.05 m. The ToF sensor produces an 11-bit fully digital output with a ToF measurement time of 22.4 ms.

10.
J Opt Soc Am A Opt Image Sci Vis ; 37(12): 2020-2031, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33362145

RESUMO

The decay behavior of specific intensity is studied for spatial-frequency domain imaging (SFDI). It is shown using the radiative transport equation that the decay is given by a superposition of different decay modes, and the decay rates of these modes are determined by spatial frequencies and Case's eigenvalues. This explains why SFDI can focus on shallow regions. The fact that light with nonzero spatial frequency rapidly decays makes it possible to exclusively extract optical properties of the top layer of a layered medium. We determine optical properties of the top layer of a solid phantom. This measurement is verified with different layered media of numerical phantoms.

11.
Mikrochim Acta ; 187(8): 466, 2020 07 21.
Artigo em Inglês | MEDLINE | ID: mdl-32691252

RESUMO

Novel sulfur-doped graphitic carbon nitride quantum dots (S-gCNQDs) are synthesized using a single-source precursor in a one-step solvothermal process. The S-gCNQDs with a size of ~ 5-nm displayed a strong green intrinsic fluorescence at 512 nm when excited at 400 nm, with a quantum yield of ~ 33% in aqueous solution. The prepared S-gCNQDs and Ag2S nanocrystals were applied as innovative functional materials to fabricate a biosensor for virus detection based on the conjugation of specific anti-human influenza A monoclonal antibody to the S-gCNQDs and Ag2S NCs, respectively. In the presence of the influenza A virus, an interaction between the S-gCNQDs/Ag2S-labeled antibody resulted in the formation of a nanosandwich structure, which is accompanied by the fluorescence enhancement of the S-gCNQDs. The change in fluorescence intensity linearly correlats with the concentration of the influenza A virus (H1N1) in the 10 fg/mL to 1.0 ng/mL range, with a limit of detection of 5.5 fg/mL. The assay was applied to the assay of clinically isolated influenza A virus (H3N2/Yokohama) mixed with human serum. The obtained limit of detection was 100 PFU/mL within the detection range of 102- 5 × 104 PFU/mL for the H3N2 virus. Graphical abstract.


Assuntos
Corantes Fluorescentes/química , Fluorimunoensaio/métodos , Grafite/química , Vírus da Influenza A Subtipo H3N2/isolamento & purificação , Nanopartículas Metálicas/química , Compostos de Nitrogênio/química , Pontos Quânticos/química , Anticorpos Imobilizados/imunologia , Anticorpos Monoclonais/imunologia , Técnicas Biossensoriais/métodos , Sangue/virologia , Humanos , Vírus da Influenza A Subtipo H3N2/imunologia , Limite de Detecção , Compostos de Prata/química , Enxofre/química
12.
Sensors (Basel) ; 20(4)2020 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-32075170

RESUMO

An 8-tap CMOS lock-in pixel image sensor that has seven carrier-capturing and a draining time window was developed for short-pulse time-of-flight (TOF) measurements. The proposed pixel for the short-pulse TOF measurements has seven consecutive time-gating windows, each of which has the width of 6 ns, which is advantageous for high-resolution range imaging, particularly for relatively longer distances (>5 m) and under high ambient light operations. In order to enhance the depth resolution, a technique for the depth-adaptive time-gating-number assignment (DATA) for the short-pulse TOF measurement is proposed. A prototype of the 8-tap CMOS lock-in pixel image sensor is implemented with a 1POLY 4METAL 0.11-µm CIS process. The maximum non-linearity error of 1.56%FS for the range of 1-6.4 m and the depth resolution of 6.4 mm was obtained at 6.2 m using the DATA technique.

13.
Opt Express ; 27(18): 26175-26191, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31510477

RESUMO

Multi-exposure laser speckle contrast imaging (MELSCI) systems based on high frame rate cameras are suitable for wide-field quantitative measurement of blood flow. However, high-speed camera-based MELSCI requires high power consumption, large memory, and high processing capability, which may lead to relatively large and expensive hardware. To realize a compact and cost-efficient MELSCI system, we discuss an application of the multi-tap CMOS image sensor originally designed for time-of-flight range imaging. This image sensor operated in the global shutter mode and every pixel was provided with multiple charge-storage diodes. Multiple images for different exposures were acquired simultaneously because exposure patterns were programmable to implement an arbitrary exposure duration for each tap. The frame rate was close to video frame rates (30 frames per second (fps)) regardless of the exposure pattern. The feasibility of the proposed method was verified by simulations that were performed with real speckle images captured by a high-speed camera at 40 kfps. Experiments with a four-tap CMOS image sensor demonstrated that a flow speed map was obtained at a moderate frame rate such as 35 fps for a moving ground glass plate and 45 fps for flowing Intralipose, which were linearly moved at speeds of 1-5 mm/s.

14.
Sensors (Basel) ; 19(13)2019 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-31262081

RESUMO

In this paper, a wide dynamic range (WDR) CMOS image sensor (CIS) with a charge splitting gate (SG) and two storage diodes (SDs) is presented. By using single-gate on/off control with the SG, photocurrent path to the first (SD1) or second storage diodes (SD2) is switched alternatively and periodically during exposure and signal electrons generated in a photodiode (PD) are transferred to and accumulated in the SD1 or SD2. By setting a large ratio of the off-time to on-time of the SG, two different sensitivity signals, which are originated by the same photodiode, are generated and a WDR image signal is obtained. This technique has a distinct advantage on mitigating the problem of motion artifact in WDR imaging with high and low sensitivity signals and flexible dynamic control of the dynamic range. An experimental WDR CMOS image sensor with 280 (H) × 406 (V)-pixel array consisting of 14 sub-arrays, each of which have 20 (H) × 406 (V) pixels, was implemented and tested. For the SG on/off-time ratio of 30 and 279, the DR of 93 dB and 104 dB, respectively, was demonstrated. The effect of the proposed WDR imaging operation on the reduced motion artifact was experimentally confirmed.

15.
Sensors (Basel) ; 19(8)2019 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-31013721

RESUMO

We demonstrate the multiband color filtering of a standard RGB color and a complementary CMY color by a plasmonic color filter, composed of concentric corrugated metallic thin film rings. The surface plasmon resonance is excited by the periodic corrugation, and the coupled light is transmitted through the central subwavelength aperture. Color selectivity is achieved not only in the visible but also in the near-infrared (NIR) region. Therefore, simultaneous imaging with visible and NIR can be realized by the integration of plasmonic color filters with sensors. We investigate the angle of incidence dependence of the transmission color selectivity and the color purity of the fabricated plasmonic color filter array.

16.
Sensors (Basel) ; 19(6)2019 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-30884852

RESUMO

A lensless camera is an ultra-thin computational-imaging system. Existing lensless cameras are based on the axial arrangement of an image sensor and a coding mask, and therefore, the back side of the image sensor cannot be captured. In this paper, we propose a lensless camera with a novel design that can capture the front and back sides simultaneously. The proposed camera is composed of multiple coded image sensors, which are complementary-metal-oxide-semiconductor (CMOS) image sensors in which air holes are randomly made at some pixels by drilling processing. When the sensors are placed facing each other, the object-side sensor works as a coding mask and the other works as a sparsified image sensor. The captured image is a sparse coded image, which can be decoded computationally by using compressive sensing-based image reconstruction. We verified the feasibility of the proposed lensless camera by simulations and experiments. The proposed thin lensless camera realized super-field-of-view imaging without lenses or coding masks and therefore can be used for rich information sensing in confined spaces. This work also suggests a new direction in the design of CMOS image sensors in the era of computational imaging.

17.
J Biophotonics ; 12(5): e201800223, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30421535

RESUMO

Widefield frequency-domain fluorescence lifetime imaging microscopy (FD-FLIM) measures the fluorescence lifetime of entire images in a fast and efficient manner. We report a widefield FD-FLIM system based on a complementary metal-oxide semiconductor camera equipped with two-tap true correlated double sampling lock-in pixels and lateral electric field charge modulators. Owing to the fast intrinsic response and modulation of the camera, our system allows parallel multifrequency FLIM in one measurement via fast Fourier transform. We demonstrate that at a fundamental frequency of 20 MHz, 31-harmonics can be measured with 64 phase images per laser repetition period. As a proof of principle, we analyzed cells transfected with Cerulean and with a construct of Cerulean-Venus that shows Förster Resonance Energy Transfer at different modulation frequencies. We also tracked the temperature change of living cells via the fluorescence lifetime of Rhodamine B at different frequencies. These results indicate that our widefield multifrequency FD-FLIM system is a valuable tool in the biomedical field.


Assuntos
Metais/química , Imagem Óptica/instrumentação , Óxidos/química , Semicondutores , Células HeLa , Humanos
18.
Opt Express ; 26(19): 25178-25187, 2018 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-30469623

RESUMO

We propose a plasmonic color filter consisting of a single aperture surrounded by concentric periodic corrugations for simultaneous imaging of a spectral range from the visible to the near-infrared. The incident light coupled with surface plasmons propagates through the sub-wavelength aperture as beaming light. The beaming light transmission is able to suppress the spatial color cross-talk between the pixels in an image sensor. We analyzed the transmission characteristics of a plasmonic color filter with periodic corrugations in a silver thin film by using the finite-difference time-domain algorithm. We demonstrated a multi-band transmission wavelength selectivity, of about 100 nm, for the spectral bandwidth ranging from visible to near-infrared. The simultaneous discrimination of visible and near-infrared light with a high color purity by the plasmonic color filter achieves both improved image recognition and smaller system-size compared with conventional systems, which is particularly important for applications such as vehicle-mounted cameras, security, and biological tissue engineering.

19.
Sensors (Basel) ; 18(6)2018 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-29865217

RESUMO

In this paper, we report on the development of a monolithic active pixel sensor for X-ray imaging using 0.2 µm fully depleted silicon-on-insulator (SOI)-based technology to support next generation astronomical satellite missions. Detail regarding low-noise dual-gain SOI based pixels with a charge sensitive amplifier and pinned depleted diode sensor structure is presented. The proposed multi-well sensor structure underneath the fully-depleted SOI allows the design of a detector with low node capacitance and high charge collection efficiency. Configurations for achieving very high charge-to-voltage conversion gain of 52 µV/e- and 187 µV/e- are demonstrated. Furthermore, in-pixel dual gain selection is used for low-noise and wide dynamic range X-ray energy detection. A technique to improve the noise performance by removing correlated system noise leads to an improvement in the spectroscopic performance of the measured X-ray energy. Taken together, the implemented chip has low dark current (44.8 pA/cm² at -30 °C), improved noise performance (8.5 e- rms for high gain and 11.7 e- rms for low gain), and better energy resolution of 2.89% (171 eV FWHM) at 5.9 keV using 55Fe and 1.67% (234 eV FWHM) at 13.95 keV using 241Am.

20.
Sensors (Basel) ; 18(3)2018 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-29510599

RESUMO

The photometric stereo method enables estimation of surface normals from images that have been captured using different but known lighting directions. The classical photometric stereo method requires at least three images to determine the normals in a given scene. However, this method cannot be applied to dynamic scenes because it is assumed that the scene remains static while the required images are captured. In this work, we present a dynamic photometric stereo method for estimation of the surface normals in a dynamic scene. We use a multi-tap complementary metal-oxide-semiconductor (CMOS) image sensor to capture the input images required for the proposed photometric stereo method. This image sensor can divide the electrons from the photodiode from a single pixel into the different taps of the exposures and can thus capture multiple images under different lighting conditions with almost identical timing. We implemented a camera lighting system and created a software application to enable estimation of the normal map in real time. We also evaluated the accuracy of the estimated surface normals and demonstrated that our proposed method can estimate the surface normals of dynamic scenes.

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