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1.
J Vet Emerg Crit Care (San Antonio) ; 32(3): 420-425, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35142423

RESUMO

OBJECTIVE: To describe renal tubular acidosis (RTA) and secondary acquired hyperaldosteronism in a cat as an adverse effect of topiramate therapy. CASE SUMMARY: An 8-year-old neutered female cat on chronic oral topiramate therapy at a recommended dose (11.9 mg/kg q 8 h) for seizure control was presented with severe metabolic acidosis and hypokalemia. Plasma electrolyte and acid-base analysis identified a severe metabolic acidosis (pH 7.153, reference interval: 7.31-7.46), hypokalemia (2.08 mmol/L [2.08 mEq/L], reference interval: 3.5-4.8 mmol/L [3.5-4.8 mEq/L]), and ionized hypercalcemia (1.85 mmol/L [1.85 mEq/L], reference range: 1.1-1.4 mmol/L [1.1-1.4 mEq/L]). Urinalysis revealed a urine specific gravity of 1.021 and a pH of 7.0. Diagnostic workup suggested distal RTA as a cause of the cat's acid-base and electrolyte disturbances. Aldosterone concentration was moderately increased, suggestive of secondary hyperaldosteronism. The metabolic abnormalities resolved with supportive care and discontinuation of topiramate. NEW OR UNIQUE INFORMATION PROVIDED: Topiramate is suggested to have led to the development severe RTA in a cat.


Assuntos
Acidose Tubular Renal , Doenças do Gato , Hiperaldosteronismo , Hipopotassemia , Acidose Tubular Renal/induzido quimicamente , Acidose Tubular Renal/diagnóstico , Acidose Tubular Renal/veterinária , Animais , Doenças do Gato/induzido quimicamente , Gatos , Eletrólitos/uso terapêutico , Feminino , Hiperaldosteronismo/complicações , Hiperaldosteronismo/veterinária , Hipopotassemia/induzido quimicamente , Hipopotassemia/complicações , Hipopotassemia/veterinária , Masculino , Topiramato/efeitos adversos
2.
J Vet Intern Med ; 35(5): 2409-2414, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34227150

RESUMO

BACKGROUND: Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a rare clinical entity of suspected congenital dyserythropoiesis and polymyopathy. Clinicopathologic changes were similar to a previously reported syndrome of congenital dyserythropoiesis, congenital polymyopathy, and cardiac disease in 3 related English Springer Spaniel (ESS) dogs, but the dogs reported here did not have apparent cardiac disease. INTERVENTIONS: Bone marrow aspiration, electromyography, muscle biopsies, and an echocardiogram were performed on dog 1. Results supported dyserythropoiesis and congenital polymyopathy similar to reports in ESS dogs, but did not identify obvious cardiac disease. CONCLUSION: The clinicopathologic changes of dyserythropoiesis and polymyopathy provide an easily recognizable phenotype for what appears to be a low morbidity syndrome. Early recognition may decrease unnecessary testing or euthanasia.


Assuntos
Doenças do Cão , Cardiopatias , Animais , Biópsia/veterinária , Medula Óssea , Doenças do Cão/diagnóstico , Cães , Eletromiografia , Cardiopatias/diagnóstico , Cardiopatias/veterinária , Masculino
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