Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy.

Renal cell carcinomas account for 2-3% of malignant neoplasms in adults. The lung, soft tissues and bone represent the most frequent sites of distant metastasis in renal cell carcinoma. Gastric metastasis is rare. Our case was a 72-year-old man with complaints of fatigue and loss of appetite. In history, he had unergone radical nephrectomy due to renal cell carcinoma in 1993. A polypoid lesion was observed in upper gastrointestinal endoscopy. Histopathology of gastric biopsy specimen was reported as renal cell carcinoma. In English literature, there are 50 cases diagnosed as gastric metastasis from renal cell carcinoma. To date, there are only 4 cases with extremely late gastric metastasis of renal cell carcinoma. Herein, we present a rare case which underwent radical nephrectomy due to renal cell carcinoma and found to have gastric metastasis at 20. year of his follow-up.

Protective role of bilberry extract against Cisplatin induced ototoxicity in rats.

To investigate the potential preventive effect of bilberry extract in cisplatin-induced ototoxicity. Thirty-five 3-3.5-month healthy adult female Sprague-Dawley rats were randomly divided into three groups and treated as follows: Both, group 1 (n = 10) and group 2 (n = 15) subjects received a single dose of 12 mg/kg cisplatin intraperitoneally; while in group 2, bilberry extract was also administered via gavage feeding for 15 days. Group 3 (n = 10), received no cisplatin or bilberry extract. Baseline distortion product otoacoustic emissions testing were performed in all subjects prior to administration of any medication. The test was repeated at 15th day following administration of any medication. The distortion product otoacoustic emissions were evaluated at 1.5, 2, 3, 4, 5, 6, 7, 8, 10 and 12 kHz. Histopathological changes in the cochlea of rats were observed by light microscopy. There was no statistically significant difference in apical turn between three groups but there was a statistically significant difference in basal and mid turn external ciliated cells number. Stria vascularis changes were statistically significant between three groups. The median score for stria vascularis injury and spiral ganglion cells changes were significantly greater in group 1 than in group 2. The initial distortion product otoacoustic emissions measurement results gave similar statistically insignificant values in the three groups (p > 0.05). In contrast to initial measurements statistically significant differences were recorded between day 0 and 15 otoacoustic thresholds (p < 0.05). Bilberry extract group had a significantly higher DP-gram except for 1.5 and 2 kHz frequencies when compared to cisplatin group. The analyses of the results revealed statistically significant differences between two groups (p < 0.05), suggesting that bilberry extract had shown a protective effect against cisplatin ototoxicity. The results of our study revealed that treatment with bilberry extract affords significant protection to the cochlea from cisplatin toxicity and thus, oral experimental dose of bilberry extract administration may have a protective effect against cisplatin ototoxicity in rats.

Histopathological examination of patients operated on for a neck mass: 4-year follow-up results.

OBJECTIVE: To investigate the diagnostic distribution of neck masses treated surgically at our clinic and also to discuss the clinical presentation and histological finding of these pathologies. MATERIAL AND METHOD: We retrospectively reviewed the records (age, sex, clinical presentation and histological findings) of 201 patients who presented at our clinic with neck masses between 2006 and 2010. RESULTS: Of the 201 patients, 98 (48.75%) were classified as inflammatory masses, 67 (33.33%) as neoplastic neck masses, and 36 (17.91%) as congenital neck masses. The mean age was 27.2±17.2 in patients with inflammatory neck masses and 11.4±4.6 for congenital neck masses. In the neoplastic neck masses group, the mean age was 37.4±11.6 for benign lesions but 49.4±20.6 in malignant lesions. CONCLUSION: When a neck mass is seen, neoplasms should be considered in older adults and inflammatory and congenital masses in children and young patients. Although the history, medical examination and additional diagnostic methods provide important information, the exact diagnosis may only be obtained by histopathological examination.

Antiphospholipid syndrome associated with malignant mesothelioma presenting with superior vena cava thrombosis: a case report.

A 59-year-old woman who had dyspnea and neck swelling for 10 days was admitted to the hospital. Malignant peritoneal mesothelioma was diagnosed previously. According to the clinical findings, and laboratory and pathologic examination, the patient was found to have disseminated venous thrombosis and antiphospholipid syndrome, which is treatment-resistant autoimmune paraneoplastic syndrome.