[Preparation and clinical trial of new dried balanced food products "Unipit" for total restorative nutrition]. / Razrabotka i klinicheskie ispytaniia novykh sukhikh sbalansirovannykh produktov "Unipit" dlia polnogo vosstanovitel'nogo pitaniia.

Designs of 2 types of dried balanced food mixtures ("Unipit-1" and "Unipit-2") intended for complete recovery nutrition of patients with retained and disordered digestive function have been validated. The chemical composition of these products has been presented. The results of clinical trials have proved the high therapeutic effectiveness of "Unipit-1" and "Unipit-2" in rehabilitation of neurosurgical patients.

[An experimental study of the biological value of milk proteins with differing ratios of casein and blood proteins]. / Eksperimental'noe izuchenie biologicheskoi tsennosti molochnykh belkov s razlichnymi sootnosheniiami kazeina i syvorotochnykh belkov.

To improve amino acid composition and to rise the sum of sulfur-containing amino acids, 5 samples of milk protein with varying ratios of casein and serum proteins (24:76; 45:55; 61:39; 73:27; 94:6) were prepared with the use of the membrane technology under conditions of experimental production. Biological experiments conducted with the use of "growth" and "balance" methods have shown a rise of biological value with the increasing of serum protein share reaching its maximum value at a ratio of 61:39. Further elevation of the serum protein share (73:27; 94:6) led to a decrease of biological value. Advantages are stressed of the membrane technology in the production of high-quality milk products.

[Prospects of using new low-calorie products based on a soybean protein isolate in the prevention and treatment of metabolic diseases]. / Perspektiva ispol'zovaniia novykh nizkokaloriinykh produktov na osnove izoliata soevogo belka v profilaktike i lechenii obmennykh zabolevanii.

In an experiment on 14 clinically healthy volunteers (12 women and 2 men) a study was made of the tolerance, assimilation and metabolic effectiveness of high-protein low-calorie food products in dietetic correction of excessive body mass. It has been noted that using soybean protein isolate as a component of low-calorie food is promising.

[Comparative biological value of the proteins comprising the products for the tube and regular feeding of patients with mandibular fractures]. / Sravnitel'naia biologicheskaia tsennost' belkov v sostave produktov zondovogo i obychnogo pitannia bol'nykh s perelomami nizhnei cheliusti.

A comparative clinical evaluation was made of the biological effectiveness of protein components in the composition of three types of diet for patients with fractures of the mandible who had received "Ensure" (USA), a product for complete tube feeding; an experimental sample developed at the Institute of Nutrition, Academy of Medical Sciences of the USSR; and a routine clinical diet. The biological effectiveness of the proteins was estimated by some anthropometric and biochemical parameters as well as on the basis of nitrogenous metabolism in the patients. It has been established that the protein content in the routine clinical diets does not meet the high requirements in amino acids of patients with fracture of the mandible. In this respect the products for tube and dietotherapy have proved to be effective and completely provide the need of such patients in essential amino acids that has been evidenced by the results of the investigations conducted.

[Clinical study of the assimilation, tolerance and metabolic effectiveness of protein products combined with a soybean isolate]. / Klinicheskoe izuchenie usvoiaemosti, perenosimosti i metabolicheskoi effektivnosti kombinirovannykh belkovykh produktov s izoliatom soi.

Combined product containing soybean isolate 500E (produced by "Ralston Purine Company", USA) were clinically used in 16 patients with hyperlipidemia, type II. The results obtained evidenced a high assimilability (95.5-95.9%) and pronounced hupocholesterolemic effect of the soybean isolate when it was used as a substitute for 2/3 or 1/2 protein volume in the ration.

[Clinico-experimental approaches to studying the hypocholesteremic action of soy proteins]. / Kliniko-éksperimental'nye podkhody k izucheniiu gipokholesterinemicheskogo deistviia belkov soi.

The effect of diets containing soybean proteins substituting a significant portion of meat proteins was studied in patients with hyperlipidemia, type IIa, and in experiments on rats. It was found that soybean proteins included into the diet induced blood plasma amino acid imbalance, changed the excretion of some amino acids with urine, and significantly diminished the blood plasma cholesterol level. In the experiments on rats a reduced rate was noted in the low-density lipoprotein apoprotein formation and high-density lipoprotein apoprotein regeneration in the blood plasma. It is suggested that the hypocholesterolemic effect of soybean proteins is caused by decreased apoprotein E synthesis and metabolism due to low levels of blood plasma lysine and arginine.

[Effectiveness of tube feeding in neurosurgical patients]. / Otsenka éffektivnosti zondovogo pitaniia u neiroreanimatsionnykh bol'nykh.

The results of the early use of gastrogavage in 24 neuroresuscitation patients are analysed. The dosage of the feeding and control over its efficacy was exercised by means of appraising energy expenditures and their structure with the use of indirect calorimetry as well as according to the nitrous balance data, biochemical criteria of the alimentary status, and the total lymphocyte count. It is shown that neuroresuscitation patients manifested appreciable changes in energy expenditures and their structure as well. It is fairly embarrassing to meet the energy requirements of such patients with the aid of the routine hospital diet. The early use of gastrogavage with the aid of dry, readily reducible mixtures of the Ensure type, that meet the neuroresuscitation patients' requirements, make intensive care more efficacious.