[The prospects for using the new macrolide antibiotic azithromycin (Sumamed) in the combined treatment of periodontitis]. / Perspektivy primeneniia novogo makrolidnogo antibiotika--azitromitsina (sumameda) v kompleksnom lechenii parodontita.

Antibacterial activity of sumamed, a macrolide antibiotic, in respect of anaerobic microflora of the oral cavity, such as Bacteroides, Prevotella, Porphyromonas, Fusobacterium, Peptostreptococcus, Str. sanguis and Staph. aureus, was assessed. The drug was found to be highly effective in respect of bacteroids (MPC90: 1,4 to 30 mg/mlMg/ml, this permitting the use of sumamed in the treatment of 9 patients with chronic generalized periodontitis in the exacerbation stage. Bacteriological and clinical control of the results of therapy demonstrated the drug efficacy in respect of periodontopathogenous flora, particularly as regards bacteroids and fusobacteria which maintain the inflammatory process in periodontitis.

[The use of immunoenzyme analysis for the diagnosis of an anaerobic infection of the maxillofacial area]. / Primenenie immunofermentnogo analiza dlia diagnostiki anaérobnoi infektsii cheliustno-litsevoi oblasti.

Solid-phase EIA was used to titer antibodies to polysaccharide and ultrasonic disintegrate antigens of the most incident agents of anaerobic infections of the maxillofacial area. Comparison of the results of EIA with polysaccharide antigens of B.melaninogenicus, B.asaccharolyticus, F.nucleatum, P.intermedius, and Str.sanguis and the results of bacteriological detection of these bacteria in a closed pyoinflammatory focus in 283 patients with maxillofacial abscesses and phlegmons brought the authors to a conclusion that the suggested EIA technique may be used to prove the contribution of these bacteria to the development of an inflammatory process in a patient. Data are presented on the frequency of detection of a diagnostically significant level of antibodies in patients with positive results of bacteriological investigation.

[Etiology of inflammatory maxillofacial diseases and estimation of the effectiveness of antibacterial drugs in vitro]. / Etiologiia vospalitel'nykh zabolevanii cheliustno-litsevoi oblasti i otsenka éffektivnosti antibakterial'nykh preparatov in vitro.

The results of identification of 710 clinical strains of anaerobic microorganisms isolated from the pathological foci of patients with maxillofacial diseases are presented. The species composition of the microflora associations in the cases with abscesses, phlegmon, lymphadenitis, osteomyelitis and parodontitis is described. Along with a high frequency of nonsporulating anaerobes, staphylococci, microaerophilic streptococci and in the cases with parodontitis actinomycetes, Bacillus licheniformis and Bacillus coagulans strains (1.6-15% of the isolated strains) were first detected in cases with various forms of the disease. Two groups of the drugs effective against the anaerobes were identified by the data on the antibiotic sensitivity. The lowest MICs along with the activity broad spectrum were defined for gramicidin, levomycetin and nitazol.