RESUMO
To compare pharmacokinetics of liquid prednisolone and prednisone solutions and to assess relative bioavailability, six healthy adult men were administered 15 mg of each formulation. Blood samples were obtained and assayed for plasma prednisolone concentrations by high-performance liquid chromatography. Peak concentration was significantly higher with liquid prednisolone (mean +/- SD 430.3 +/- 62.5 vs 333.0 +/- 27.8 ng/ml, p = 0.013), with similar times to peak concentration. Prednisolone liquid gave higher concentrations at every time point (statistically significant for all except 0.25 hrs after the dose), resulting in a significantly greater total area under the curve (2029.8 +/- 246.9 vs 1633.3 +/- 221.1 ng/ml.hour, respectively, p = 0.002). Clearance was slower for prednisolone (128.3 +/- 15.1 vs 149.1 +/- 17.6 ml/min/1.73 m2, p = 0.01), and the relative bioavailability of the prednisolone liquid using prednisone liquid as the reference standard was 116 +/- 14%. Thus, prednisolone liquid has similar pharmacokinetic characteristics as prednisone liquid, with improved bioavailability.
Assuntos
Glucocorticoides/farmacocinética , Prednisolona/farmacocinética , Prednisona/farmacocinética , Administração Oral , Adulto , Disponibilidade Biológica , Glucocorticoides/administração & dosagem , Humanos , Masculino , Prednisolona/administração & dosagem , Prednisona/administração & dosagem , SoluçõesRESUMO
Although discussed for many years, systemic adverse effects from inhaled corticosteroid therapy remains a complicated and controversial topic. It is by now well-known that inhaled corticosteroids may affect growth, bone, and adrenal function, yet the clinical relevance and the risks for such adverse effects are poorly defined. Earlier intervention, use of higher doses, differing potency claims, and new inhalers also affect the potential for systemic effects following inhaled administration. Until further research better characterizes these risks and identifies appropriate monitoring, caution in the use of this highly effective therapy is advised.
Assuntos
Asma/tratamento farmacológico , Glucocorticoides/efeitos adversos , Administração por Inalação , Glândulas Suprarrenais/efeitos dos fármacos , Glândulas Suprarrenais/fisiopatologia , Criança , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Crescimento/efeitos dos fármacos , HumanosRESUMO
OBJECTIVE: To introduce and review zileuton, an orally active 5-lipoxygenase inhibitor that represents the first of a new class of medications to be used in the treatment of asthma. DATA SOURCES: A MEDLINE search (from 1966 to December 1995) was performed to identify pertinent English-language literature. STUDY SELECTION: Basic science studies on the pharmacokinetics of zileuton, its pathophysiologic effects on asthma, and clinical efficacy trials were reviewed. DATA EXTRACTION: Clinical trials were emphasized. Studies from ex vivo or animal models of pharmacologic and pharmacodynamic effects were considered for review where no in vivo human data were available. DATA SYNTHESIS: Zileuton has shown the ability to attenuate induced bronchospasm, produce some degree of bronchodilation, and provide antiinflammatory or steroid-sparing effects with both single doses (800 mg) and chronic treatment (400 and 600 mg qid). Zileuton has been studied in patients requiring daily inhaled beta-adrenergic agonist treatment; however, data from pediatric populations and comparisons with other asthma medications are limited at this time. Adverse effects include dyspepsia and elevated liver enzymes (incidence approximately 3%). One case of jaundice has been reported among the more than 5000 patients treated with zileuton. There is also some concern for drug interactions with hepatically cleared medications, such as theophylline. CONCLUSIONS: Zileuton represents the first drug of a new treatment category for asthma, the 5-lipoxygenase inhibitors. Some people with asthma may receive considerable benefit, but as it is an entirely new drug entity, zileuton's final place in the hierarchy of asthma medications remains to be determined.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Hidroxiureia/análogos & derivados , Inibidores de Lipoxigenase/uso terapêutico , Animais , Asma/sangue , Asma/fisiopatologia , Líquido da Lavagem Broncoalveolar/citologia , Ensaios Clínicos como Assunto , Interações Medicamentosas , Humanos , Hidroxiureia/efeitos adversos , Hidroxiureia/farmacologia , Hidroxiureia/uso terapêutico , Teofilina/uso terapêuticoAssuntos
Antiasmáticos/administração & dosagem , Antiasmáticos/efeitos adversos , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/efeitos adversos , Administração por Inalação , Administração Tópica , Glândulas Suprarrenais/efeitos dos fármacos , Androstadienos/administração & dosagem , Androstadienos/efeitos adversos , Asma/tratamento farmacológico , Beclometasona/administração & dosagem , Beclometasona/efeitos adversos , Budesonida , Relação Dose-Resposta a Droga , Fluocinolona Acetonida/administração & dosagem , Fluocinolona Acetonida/efeitos adversos , Fluocinolona Acetonida/análogos & derivados , Fluticasona , Glucocorticoides , Crescimento/efeitos dos fármacos , Humanos , Osteoporose/induzido quimicamente , Pregnenodionas/administração & dosagem , Pregnenodionas/efeitos adversos , Triancinolona Acetonida/administração & dosagem , Triancinolona Acetonida/efeitos adversosRESUMO
To determine if ciprofloxacin therapy alters the response to warfarin treatment, 36 adult patients attending three university-affiliated outpatient anticoagulation clinics randomly received a 12-day course of ciprofloxacin (750 mg twice daily) and a 12-day course of placebo; each course was separated by a 2-week washout period. Prothrombin times (PTs), concentrations of S-warfarin and R-warfarin (the isomers of warfarin), and concentrations of clotting factors II and VII were determined three times weekly for 9 weeks. By day 12 of ciprofloxacin therapy, concentrations of S-warfarin remained unchanged compared with those after placebo therapy, but R-warfarin concentrations increased significantly (1.15 times those after placebo therapy; P = .001); concentrations of clotting factors II and VII decreased (0.903 and 0.872 times those after placebo therapy, respectively, P < or = .020). The mean PT ratio after 12 days of ciprofloxacin therapy increased slightly (1.032 times that after placebo therapy; P = .057), but no patient had bleeding or a change in PT that required alteration in warfarin or ciprofloxacin therapy. We conclude that warfarin therapy is not a contraindication to the use of ciprofloxacin.
Assuntos
Anti-Infecciosos/farmacologia , Anticoagulantes/farmacocinética , Ciprofloxacina/farmacologia , Varfarina/farmacocinética , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/uso terapêutico , Método Duplo-Cego , Interações Medicamentosas , Fator VII/análise , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Protrombina/análise , Tempo de Protrombina , Varfarina/uso terapêuticoRESUMO
The effects of asthma and oral and inhaled glucocorticoid therapy on growth in children are reviewed. Previous reports have shown that asthma itself may delay the onset of puberty, an effect which may masquerade as growth suppression. Oral glucocorticoids appear to impair growth; however, lower doses and alternate-day therapy may have less risk of this effect. While a controversial topic, inhaled glucocorticoids in lower doses appear to be associated with a small risk of adverse effects on growth. Minimal data are available for higher doses. Knemometry, a relatively new technique used for measuring small changes in growth, has detected short-term effects with both oral and inhaled glucocorticoids therapy. However, a number of limitations are associated with short-term growth studies. Clinicians should be aware of the potential for growth impairment with glucocorticoid therapy so adequate monitoring can be undertaken and appropriate intervention introduced when deemed necessary.
Assuntos
Asma/fisiopatologia , Glucocorticoides , Transtornos do Crescimento/etiologia , Adolescente , Asma/complicações , Asma/tratamento farmacológico , Criança , Pré-Escolar , Glucocorticoides/efeitos adversos , Glucocorticoides/uso terapêutico , Transtornos do Crescimento/fisiopatologia , HumanosRESUMO
GCs are used commonly for the treatment of various inflammatory and autoimmune diseases. Although potent and generally effective, they are not without risks for producing serious adverse effects, especially when used in high doses for prolonged periods of time. Thus, the clinician must balance the therapeutic effects of GCs with their risks for adverse effects; using the lowest possible effective GC doses as well as maximizing other therapeutic modalities are means by which this goal can be achieved. Early recognition and appropriate management are other methods to minimize GC-induced adverse effects. Maximization of therapy, early recognition, and appropriate management of adverse effects can minimize the potential severe complications of GC therapy.
Assuntos
Glucocorticoides/efeitos adversos , Glucocorticoides/uso terapêutico , Varicela/imunologia , Criança , Humanos , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Osteoporose/induzido quimicamente , Estresse Fisiológico/fisiopatologia , Procedimentos Cirúrgicos OperatóriosAssuntos
Albuterol/análogos & derivados , Asma/tratamento farmacológico , Broncodilatadores/uso terapêutico , Doença Aguda , Adolescente , Adulto , Albuterol/efeitos adversos , Albuterol/economia , Albuterol/uso terapêutico , Broncodilatadores/efeitos adversos , Broncodilatadores/economia , Esquema de Medicação , Humanos , Pessoa de Meia-Idade , Xinafoato de SalmeterolRESUMO
OBJECTIVE: To introduce readers to the current controversial topics in the area of asthma therapy. Background is provided such that clinicians are aware of these issues and can make rational decisions. DATA SOURCES: Pertinent articles were individually identified and reviewed from each journal. STUDY SELECTION: Relevant studies, determined by topic and other specific criteria, e.g., testing methodology, were included. DATA SYNTHESIS: Further investigation is required in the areas discussed. Systemic effects, specifically growth suppression (in children), adrenal suppression, and osteoporosis, have been demonstrated with high-dose inhaled glucocorticoids; however, the clinical relevance of such intravenous glucocorticoid formulations via nebulizer have not been demonstrated. Likewise, data on the equivalence of the inhaled glucocorticoids, with regard to efficacy and potential systemic effects, and the differences between metered-dose inhalers and dry powder inhalers, with regard to aerosol characteristics and drug delivery, are unclear. Theophylline, when used with inhaled beta-adrenergic agonists and systemic glucocorticoids for the treatment of acute asthma, as not been shown to provide clear benefit and may result in increased adverse effects. The use of regular (vs. "as needed" or prn) inhaled beta-adrenergic agonists, although shown in two studies to be detrimental to the control of asthma and result in an increased risk of death or near death caused by asthma, has not been conclusively demonstrated to be harmful. CONCLUSIONS: Monitoring for adverse effects and the use of techniques to minimize systemic absorption (spacers and mouth rinsing) are recommended when high-dose inhaled glucocorticoid therapy is used. Intranasal and intravenous glucocorticoid products are not recommended for administration via nebulizer because of safety concerns. Until further data are available, inhaled glucocorticoids are thought to be equivalent on a microgram-per-microgram basis rather than an actuation-per-actuation basis. Theophylline is no longer recommended for treatment of acute exacerbations in nonhospitalized patients not already receiving the medication, and the link between deterioration of asthma control (and the risk for death) and regular inhaled beta-adrenergic agonists appears weak.
Assuntos
Agonistas Adrenérgicos beta/farmacologia , Asma/tratamento farmacológico , Glucocorticoides/farmacologia , Teofilina/farmacologia , Administração por Inalação , Agonistas Adrenérgicos beta/efeitos adversos , Criança , Pré-Escolar , Esquema de Medicação , Glucocorticoides/efeitos adversos , Inibidores do Crescimento , Humanos , Sistema Hipotálamo-Hipofisário/efeitos dos fármacos , Lactente , Nebulizadores e Vaporizadores , Osteocalcina/metabolismo , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Teofilina/efeitos adversosRESUMO
Rapid glucocorticoid clearance and abnormal glucocorticoid receptor binding have been described as factors that contribute to an inadequate response to treatment with glucocorticoids in patients with asthma. We report the coexistence of these abnormalities in children with severe asthma who respond poorly to systemic glucocorticoid therapy.
Assuntos
Asma/tratamento farmacológico , Metilprednisolona/farmacocinética , Prednisolona/farmacocinética , Receptores de Glucocorticoides , Adolescente , Asma/metabolismo , Criança , Feminino , Humanos , Masculino , Taxa de Depuração Metabólica , Metilprednisolona/uso terapêutico , Prednisolona/uso terapêuticoRESUMO
The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied. Patients were classified as steroid sensitive (SS) if their morning FEV1 increased > 30% after a 1-wk course of oral prednisone 20 mg twice daily and steroid resistant (SR) if they failed to increase > 15%. PBMC obtained from these two groups, 17 SR and 12 SS, as well as 12 normal controls were analyzed. SR patients had two distinguishable GR binding abnormalities: 15 of the 17 SR patients demonstrated a significantly reduced GR binding affinity, as compared with SS patients (P = 0.0001) and normal controls (P = 0.0001). This defect was localized to T cells and reverted to normal after 48 h in culture media. However, incubation with a combination of IL-2 and IL-4 sustained this abnormality. The other two SR patients had an abnormally low GR number with normal binding affinity that was not limited to T cells. Furthermore, GR number failed to normalize after incubation in media alone or IL-2 and IL-4. Therefore, SR asthma may be due to more than one abnormality, the majority related to a reversible cytokine-induced reduction in GR binding affinity and the second related to an irreversible reduction in GR number. These findings may have important implications for the design of alternative treatment approaches for recalcitrant asthma.
Assuntos
Asma/tratamento farmacológico , Asma/fisiopatologia , Resistência a Medicamentos , Volume Expiratório Forçado/efeitos dos fármacos , Prednisona , Receptores de Glucocorticoides/metabolismo , Linfócitos T/metabolismo , Adulto , Asma/metabolismo , Núcleo Celular/metabolismo , Citosol/metabolismo , Dexametasona/metabolismo , Feminino , Humanos , Masculino , Monócitos/metabolismo , Prednisona/uso terapêutico , Ensaio Radioligante , Valores de ReferênciaRESUMO
BACKGROUND: Troleandomycin (TAO), a macrolide antibiotic, was studied as an alternative treatment in 18 children with severe, steroid-requiring asthma. METHODS: In this investigation three treatment arms were used in randomized, double-blind, parallel fashion: combination TAO and methylprednisolone (MPn), combination TAO and prednisone, and MPn alone. RESULTS: All groups tolerated a considerable reduction in glucocorticoid dose over the 12 weeks of the study: 80% +/- 6% for TAO-MPn, 55% +/- 8% for TAO-prednisone, and 44% +/- 14% for MPn alone. These reductions are all statistically significant (p < 0.05) within groups, and the differences between groups were statistically significant between the TAO-MPn and MPn alone groups. The concentration of methacholine required to induce a 20% decrease in forced expiratory volume in 1 second and pulmonary function were not significantly improved in any treatment group. Safety parameters including blood chemistry and hematology, adrenal function assessment; bone densitometry, and muscle strength testing, were not altered significantly. Two patients who received TAO had elevated liver enzyme levels; one required discontinuation of TAO and one experienced spontaneous resolution without intervention. Lack of statistically significant changes in the efficacy parameters were likely a result of small sample size and effects of the glucocorticoid dose taper. CONCLUSIONS: TAO is safe and may be a reasonable treatment alternative in a limited trial for patients who are unable to tolerate tapering of their glucocorticoid dosage. Therapy should be guided by the goal of treatment, that is, glucocorticoid dose reduction or improvement of pulmonary function with appropriate monitoring of pulmonary function and adverse effects.
Assuntos
Asma/tratamento farmacológico , Glucocorticoides/uso terapêutico , Troleandomicina/uso terapêutico , Adolescente , Criança , Método Duplo-Cego , Feminino , Humanos , Masculino , Metilprednisolona/uso terapêutico , Troleandomicina/efeitos adversosRESUMO
While much information has recently been obtained regarding the features of steroid-resistant asthma, it continues to be a dilemma for practitioners, and investigation into its mechanisms will remain an important part of asthma research. Until a clear marker defining steroid-resistant asthmatics is found, the principle first put forth by Carmichael and colleagues should be adhered to: that is, asthmatics resistant to glucocorticoid therapy need to be identified at an early stage so that unnecessary and perhaps harmful therapy can be discontinued. A 10 day course of high-dose (> or = 30 mg/day) systemic glucocorticoid therapy, as suggested by Kamada and colleagues, may constitute an adequate trial and may sufficiently identify asthmatics who may require alternative treatments. A more rational approach to the selection of alternative asthma treatments will be gained when the mechanisms of steroid resistance are identified.
Assuntos
Asma/tratamento farmacológico , Glucocorticoides/uso terapêutico , Asma/sangue , Asma/imunologia , Asma/fisiopatologia , Dexametasona/farmacologia , Relação Dose-Resposta a Droga , Resistência a Medicamentos , Humanos , Pico do Fluxo Expiratório/efeitos dos fármacos , Prednisona/farmacologia , Linfócitos T/efeitos dos fármacosAssuntos
Asma/tratamento farmacológico , Glucocorticoides/uso terapêutico , Administração por Inalação , Adolescente , Albuterol/administração & dosagem , Criança , Relação Dose-Resposta a Droga , Resistência a Medicamentos/imunologia , Feminino , Volume Expiratório Forçado , Glucocorticoides/administração & dosagem , Humanos , Masculino , Teofilina/administração & dosagemAssuntos
Asma/tratamento farmacológico , Beclometasona/efeitos adversos , Broncodilatadores/efeitos adversos , Sistema Hipotálamo-Hipofisário/efeitos dos fármacos , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Administração por Inalação , Aerossóis , Beclometasona/administração & dosagem , Broncodilatadores/administração & dosagem , Budesonida , Criança , Depressão Química , Humanos , Pregnenodionas/administração & dosagem , Pregnenodionas/efeitos adversosRESUMO
Alternative treatments such as troleandomycin methotrexate, gold, and intravenous gamma globulin are sometimes considered for severe asthmatics to minimize the need for systemic corticosteroids and reduce adverse effects. These alternative therapies may also be associated with significant toxicity and expense. The ability to reduce corticosteroid use and the need for alternative treatment interventions in 125 pediatric patients at our institution were reviewed. Because corticosteroid requirements were reduced significantly, only 23 of 125 children evaluated were considered for treatment alternatives with only 10 receiving such therapy. This study emphasizes the importance of a thorough and comprehensive review of corticosteroid requirements and usage prior to initiating alternative approaches to treatment in moderate to severe asthmatics as well as in patients thought to be "steroid-dependent."
Assuntos
Corticosteroides/uso terapêutico , Asma/tratamento farmacológico , Administração por Inalação , Administração Oral , Adolescente , Criança , Pré-Escolar , Esquema de Medicação , Feminino , Humanos , Masculino , Transtornos Relacionados ao Uso de Substâncias/terapiaRESUMO
Troleandomycin (TAO) is an alternative agent used in the treatment of severe, steroid-requiring asthma. Its mechanism of action, once thought to be inhibition of theophylline clearance, remains unclear. Twenty-four-hour theophylline profiles were obtained in 11 children with severe asthma prior to and after 2 and 12 weeks of low-dose TAO therapy. Theophylline dosages were adjusted by blinded investigators to maintain serum theophylline concentrations (STCs) between 10 and 20 micrograms/ml. Dosages were decreased from 877 +/- 60 mg/day (mean +/- SEM) before TAO to 811 +/- 56 mg/day (NS) after 2 weeks and 764 +/- 56 mg/day (p less than 0.05) after 12 weeks. Because of the dosage adjustments, STCs did not increase significantly. Theophylline clearance was reduced from 65.7 +/- 9.8 ml/kg/hour at baseline to 50.2 +/- 4.1 ml/kg/hour (p less than 0.05) after 2 weeks and 50.1 +/- 6.2 ml/kg/hour (p less than 0.05) after 12 weeks of TAO therapy. We conclude that TAO can significantly reduce theophylline clearance, resulting in increased STCs if dosages are not titrated. We recommend an empiric 25% reduction of daily theophylline dose with the initiation of TAO. We also recommend monitoring STCs 4 hours after the morning dose (with twice-daily dosing of sustained-release products) after 3, 7, 14, and 30 days of TAO therapy, then periodically as indicated.