RESUMO
Platypnea-orthodeoxia syndrome is a rare cause of positional hypoxemia and dyspnea. We present the case of a 54-year-old man with right-to-left shunting through a patent foramen ovale in the setting of metastatic cholangiocarcinoma resulting in platypnea-orthodeoxia syndrome. The shunt was originally not visualized on cardiac magnetic resonance imaging but later detected with transesophageal echocardiography. This case highlights the importance of complimentary multimodality cardiac imaging in the diagnosis of both common and uncommon disorders.
Assuntos
Neoplasias dos Ductos Biliares , Colangiocarcinoma , Forame Oval Patente , Masculino , Humanos , Pessoa de Meia-Idade , Síndrome de Platipneia Ortodeoxia , Postura , Forame Oval Patente/diagnóstico , Forame Oval Patente/diagnóstico por imagem , Ecocardiografia Transesofagiana/efeitos adversos , Dispneia/etiologia , Dispneia/complicações , Hipóxia/diagnóstico , Hipóxia/etiologia , Colangiocarcinoma/complicações , Colangiocarcinoma/diagnóstico , Neoplasias dos Ductos Biliares/complicações , Neoplasias dos Ductos Biliares/diagnóstico , Ductos Biliares Intra-HepáticosRESUMO
Amyloid-beta (Aß) deposition occurs in the early stages of Alzheimer's disease (AD), but the early detection of Aß is a persistent challenge. Herein, we engineered a near-infrared optical nanosensor capable of detecting Aß intracellularly in live cells and intracranially in vivo. The sensor is composed of single-walled carbon nanotubes functionalized with Aß wherein Aß-Aß interactions drive the response. We found that the Aß nanosensors selectively responded to Aß via solvatochromic modulation of the near-infrared emission of the nanotube. The sensor tracked Aß accumulation in live cells and, upon intracranial administration in a genetic model of AD, signaled distinct responses in aged mice. This technology enables the interrogation of molecular mechanisms underlying Aß neurotoxicity in the development of AD in living systems.
