1.
Sci Transl Med
; 14(670): eabo4997, 2022 11 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36350991
RESUMO
Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.