RESUMO
We describe the management and clinical outcome of pregnancies among 100 Greek Cypriot women with thalassaemia: 88 with thalassaemia major and 12 with thalassaemia intermedia. A total of 152 successful pregnancies and 161 deliveries were included. All patients had endocrine assessment and frequent ferritin measurements. Multiple successful pregnancies included 7 twins and 1 triple pregnancy. Pregnant thalassaemics required significantly larger amount of total blood transfusion during pregnancy. There was a statistically significant increase in the ferritin levels during pregnancy, and levels remained significantly higher after pregnancy. Most pregnancies resulted in delivery of full-term healthy babies, and obstetric complications were rare, although some problems were encountered.
Assuntos
Transfusão de Sangue/estatística & dados numéricos , Cuidado Pós-Natal/organização & administração , Complicações Hematológicas na Gravidez/terapia , Resultado da Gravidez/epidemiologia , Cuidado Pré-Natal/organização & administração , Talassemia/terapia , Assistência ao Convalescente , Parto Obstétrico/métodos , Parto Obstétrico/estatística & dados numéricos , Feminino , Ferritinas/sangue , Aconselhamento Genético , Grécia/epidemiologia , Necessidades e Demandas de Serviços de Saúde , Humanos , Monitorização Fisiológica , Guias de Prática Clínica como Assunto , Gravidez , Complicações Hematológicas na Gravidez/sangue , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/epidemiologia , Estudos Retrospectivos , Estatísticas não Paramétricas , Talassemia/sangue , Talassemia/diagnóstico , Talassemia/epidemiologiaRESUMO
We describe the management and clinical outcome of pregnancies among 100 Greek Cypriot women with thalassaemia: 88 with thalassaemia major and 12 with thalassaemia intermedia. A total of 152 successful pregnancies and 161 deliveries were included. All patients had endocrine assessment and frequent ferritin measurements. Multiple successful pregnancies included 7 twins and 1 triple pregnancy. Pregnant thalassaemics required significantly larger amount of total blood transfusion during pregnancy. There was a statistically significant increase in the ferritin levels during pregnancy, and levels remained significantly higher after pregnancy. Most pregnancies resulted in delivery of full-term healthy babies, and obstetric complications were rare, although some problems were encountered
Assuntos
Talassemia , Mulheres , Transfusão de Sangue , Ferritinas , Estudos Retrospectivos , Hormônios , Testes de Função Cardíaca , Resultado da GravidezRESUMO
The effect of acute and chronic maternal administration of metoclopramide on prolactin levels in serum of umbilical vein and artery was investigated in 30 women with normal term pregnancy during labor. Serum maternal prolactin increased significantly when 20 mg metoclopramide was given intravenously 30 to 45 minutes before vaginal delivery. Prolactin values in serum of umbilical vessels did not change as compared with control values when metoclopramide was given to the mother either as a 20-mg intravenous bolus injection or per os for the last 4 days of pregnancy until delivery. Oral administration of metoclopramide in late pregnancy evoked a significant increase in maternal serum prolactin levels. It is suggested that, in humans, therapeutic doses of metoclopramide administered to the mother in late pregnancy stimulate maternal, but not fetal, prolactin secretion.
