RESUMO
We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium-based algorithm. Five tag SNPs in 2 genes (AICDA and CASP14) remained significant after adjusted multiple tests. The most significant association with childhood brain tumor risk was for IVS1-401G>C in the AICDA gene [odds ratio (OR) = 2.8; 95% confidence interval (95%CI) = 1.25-6.46]; the polymorphism *9276A>C of CASP14 was associated with decreased brain tumor risk (OR = 0.4; 95%CI = 0.19-0.95). We concluded that genetic polymorphisms in AICDA and CASP14 are associated with risk for brain tumor in Korean children.
Assuntos
Neoplasias Encefálicas/genética , Caspases/genética , Citidina Desaminase/genética , Estudos de Associação Genética , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único/genética , Apoptose/genética , Ciclo Celular/genética , Criança , Pré-Escolar , Feminino , Humanos , Masculino , República da Coreia , Fatores de RiscoRESUMO
The purpose of this study is to present the results of laser surgery for Bartholin's cyst which shows to be a method that is safe, efficient, of low morbidity, and can be performed in an outpatient clinic under local anesthesia. Of the 22 cases operated on, only two had relapses which were resolved using a second procedure. The average surgery time was short, without bleeding during the operation. Complete epithelization was achieved within a maximum 4-week span with minimal or no postoperative discomfort.