[Dissertations 25 years after date 45. Prevalence and etiology of craniomandibular dysfunction in the Netherlands]. / Proefschriften 25 jaar na dato 45. Prevalentie en etiologie van craniomandibulaire disfunctie in Nederland.

The disorders temporomandibular dysfunction and craniomandibular dysfunction are still being discussed intensely in the literature 25 year after the publication of the dissertation 'Prevalence and etiology of craniomandibular dysfunction. An epidemiological study of the Dutch adult population'. Attention is especially being devoted to occlusion and its relationship with this disorder; the conclusions reached are often contradictory. In addition to the definitions of temporomandibular and craniomandibular dysfunction and of occlusion, a possible explanation for this controversy can be found in the methodological shortcomings of the studies. On the basis of the most important results in the dissertation of 25 years ago and the scientific discussion since, 7 guidelines are formulated that are illustrated with clinical examples for an evidence-based treatment of patients with this disorder in a general dental practice.

Efficacy of signal-averaged electrocardiography in the young orthotopic heart transplant patient to detect allograft rejection.

Endomyocardial biopsy is the gold standard survey for cardiac graft rejection. Signal-averaged electrocardiography (SAECG) identifies slowly conducting, diseased myocardium. We sought to determine whether SAECG is a sensitive, noninvasive transplant surveillance method in the young.Ninety-four SAECGs recorded prior to biopsy in 20 young transplant (OHT) patients and those from 15 healthy age-matched controls (CTL) were analyzed. In the OHT group, 56 no-rejection (NOREJ) (ISHLT grades 0 or 1 A) and 37 acute rejection (REJ) (ISHLT grades IB, 2, and 3A) SAECGs were compared, SAECGs were filtered at 40-255 Hz. Total QRS duration (QRSd), duration of terminal low amplitude of QRS under 40 microV (LAS), and root mean square amplitude of terminal 40 msec of QRS (RMS40) were compared.SAECGs were significantly different in CTL vs NOREJ but not in NOREJ vs REJ: QRSd, 81.7 +/- 8, 107.2 +/- 18.4, and 112.3 +/- 21.6 msec, respectively; LAS, (18 +/- 5.8, 23.6 +/- 10.7, and 27 +/- 14.8 msec, respectively; and RMS40, (169.3 +/- 100.4, 68 +/- 48.8, and 57.5 +/- 45.6 microV, respectively. Children following OHT exhibited significant differences in the SAECG compared to controls. Differences between the NOREJ and REJ groups were negligible. Therefore, SAECG may not be effective in detecting OHT rejection in the young.

Anaesthetic management of a parturient with the postural orthostatic tachycardia syndrome: a case report.

Postural orthostatic tachycardia syndrome encompasses a group of disorders characterized by orthostatic intolerance. We describe the anaesthetic management of analgesia for labour and of Caesarean section in a parturient suffering from this disorder. Worsening of her symptoms during pregnancy was managed with an increase in the dose of beta-blockers taken by the patient. Epidural analgesia was instigated early to attenuate the stress of labour and avoid consequent triggering of a tachycardic response. Slow titration of epidural analgesia and anaesthesia after an adequate fluid preload was undertaken to minimize hypotension and subsequent tachycardia. Neuraxial opioid, combined with non-steroidal anti-inflammatory drugs and bilateral iliohypogastric and ilioinguinal nerve blocks were used to optimize postoperative analgesia.

Patients' satisfaction in two long-term clinical studies on resin-bonded bridges.

This study aimed to evaluate patients' satisfaction with resin-bonded bridges and the effect of failures on the degree of satisfaction. In two clinical trials, 358 patients completed guided questionnaires at regular recalls (n=1484). In this way, data regarding 'overall function', 'colour', 'shape', 'functional changes', 'complaints' and 'recommendation to other patients' were obtained. The scores of each criterion were evaluated for the variables 'trial', 'gender', 'time after placement' and 'failure', using 4-way ANOVA. Encountered failures were rated using a 'failure severity scale'. For all combinations of measurement periods, the changes in patient's opinions were calculated and the differences tested using the paired t-test. Overall satisfaction was correlated with 'colour', 'shape' and inversely correlated with 'complaints' (r>0.34; all P<0.005). No statistical differences were found between males and females. No significant changes were observed in patient satisfaction over time. Failures influenced the failure sensitive variables 'functional changes' and 'avoidance of load'. The z-scores were independent of the severity of the failures (r<0.13; all P>0. 10). The degree of patient satisfaction with resin-bonded bridges appeared to be high and did not seem to be influenced by the occurrence of failure.

A systematic review of single-tooth restorations supported by implants.

OBJECTIVES: To make an inventory of clinical studies on single-tooth restorations supported by implants using a systematic review procedure and to aggregate overall survival results. DATA SOURCES: Papers referring to single-tooth implants were located by a MEDLINE search 1990 to April 1998. Three hundred and twenty references were found, and they were subjected to a systematic review procedure. STUDY SELECTION: A three-step inclusion/exclusion procedure was applied to identify papers that represented: good scientific practice (GSP), reported results of all patients, implants and crowns for more than 2years, and had sufficient data to generate life-table analyses. The outcomes were 'implant failure' and 'crown completion'. Nine studies survived. These data showed an overall mean GSP of 0.37 with a predicted 4year implant survival of 97% (n=459), and an uncomplicated crown maintenance of 83% (n=240). CONCLUSION: Single-tooth implants show an acceptable short-term survival of 4years, but crown complications are common.

Radiofrequency catheter ablation of supraventricular tachycardia substrates after mustard and senning operations for d-transposition of the great arteries.

OBJECTIVES: The purpose of this study was to determine the efficacy and risks of radiofrequency ablation of various forms of supraventricular tachycardia after Mustard and Senning operations for d-transposition of the great arteries. BACKGROUND: In this patient group, the reported success rate of catheter ablation of intraatrial reentry tachycardia is about 70% with a negligible complication rate. There are no reports of the use of radiofrequency ablation to treat other types of supraventricular tachycardia. METHODS: Standard diagnostic criteria were used to determine supraventricular tachycardia type. Appropriate sites for attempted ablation included 1) intraatrial reentry tachycardia: presence of concealed entrainment with a postpacing interval similar to tachycardia cycle length; 2) focal atrial tachycardia: a P-A interval < or =-20 ms; and 3) typical variety of atrioventricular (AV) node reentry tachycardia: combined electrographic and radiographic features. RESULTS: Nine Mustard and two Senning patients underwent 13 studies to successfully ablate all supraventricular tachycardia substrates in eight (73%) patients. Eight of eleven (73%) patients having intraatrial reentry tachycardia, 3/3 having typical AV node reentry tachycardia, and 2/2 having focal atrial reentry tachycardia were successfully ablated. Among five patients having intraatrial reentry tachycardia (IART) and not having ventriculoatrial (V-A) conduction, two suffered high-grade AV block when ablation of the systemic venous portion of the medial tricuspid valve/inferior vena cava isthmus was attempted. CONCLUSIONS: Radiofrequency catheter ablation can be effectively and safely performed for certain supraventricular tachycardia types in addition to intraatrial reentry. A novel catheter course is required for slow pathway modification. High-grade AV block is a potential risk of lesions placed in the systemic venous medial isthmus.

Coexisting preexcitation syndrome and intermittent heart block presenting as neonatal seizures.

An infant presented with neonatal syncope and seizures. An ECG showed a preexcitation pattern, most compatible with Wolff-Parkinson-White (WPW) syndrome. Rhythm monitoring during an event demonstrated prolonged periods of complete AV block with no ventricular escape mechanism. We postulated that ventricular asystole was initiated by mechanical or autonomic influences on the accessory pathway and sustained by electrophysiologic interactions between the accessory pathway and the junctional escape focus. This is the first case report of a newborn having coexisting congenital AV block and WPW syndrome.

[Five year survival of posterior adhesive bridges. Influence of bonding systems and tooth preparation]. / Vijfjaarsoverleving van adhesiefbruggen in de zijdelingse delen. De invloed van hechtsysteem en preparatievorm.

The present study reports the final analysis of a randomized controlled clinical trial in which different designs of posterior resin-bonded bridges were evaluated for a period of at least 5 years. The operational hypothesis was that the bonding system and the preparation design used in posterior resin-bonded bridges have an influence on the survival and clinical functioning of these restorations. Survival in this study was defined at two levels: (1) 'primary' survival (survival without any debonding), and (2) 'functional' survival (survival including loss of retention on one occasion and successful rebonding of the original resin-bonded bridge without further debonding). Preparation of grooves in abutment teeth for posterior resin-bonded bridges appeared to be beneficial to their chance of survival. Resin-bonded bridges placed in the maxilla have a better prognosis than those made in the mandible. The bonding systems used in this study (etching/Clearfil F2, sand blasting/Panavia EX and silica-coating/Microfill Pontic C) appear to have no influence on the chance of failure with regards to the 'primary' survival. In rebonded posterior resin-bonded bridges, the bonding system silica coating/Microfill Pontic C was more retentive than the other systems tested.

Loss of sound tooth structure when replacing amalgam restorations by adhesive inlays.

The replacement of amalgam restorations by adhesive inlays requires an adjustment to the cavity form. This often necessitates the removal of sound tooth substance. Undercuts may be blocked out by a base, but an extensive use of glass ionomer for this purpose is not recommended due to the weak mechanical properties of this material. The present study estimated the amount of sound tissue removed when a given amalgam preparation was reshaped for an adhesive inlay without the use of a base. An MOD amalgam preparation was created in an acrylic tooth. Twenty copies were distributed among 20 operators, who were requested to transform the preparation into an adhesive inlay preparation, removing as little material as possible. One control preparation with parallel walls was produced. All teeth were weighed before and after the alteration. The preparations' volumes were calculated: original amalgam preparation 0.130 ml, parallel preparation 0.136 ml. The minimum removal necessary was therefore 0.006 ml. The amount removed by the operators varied, with a mean volume of 0.0138 +/- 0.004 ml. Statistical analysis showed that for the given preparation, significantly more material was removed than necessary for undercut elimination. On average, more than twice the minimal volume of material was lost. This loss can be minimized by developing alternative techniques for undercut elimination.

Radiofrequency catheter ablation of multiple haemodynamically unstable ventricular tachycardias in a patient with surgically repaired tetralogy of Fallot.

A patient with repaired tetralogy of Fallot presented with recurrent syncope and had multiple haemodynamically unstable ventricular tachycardias unresponsive to antiarrhythmic medications. Ventricular tachycardias became haemodynamically tolerated with amiodarone, procainamide and dopamine, permitting activation and entrainment mapping. Radiofrequency ablation of three tachycardia circuits was performed. Ventricular tachycardia could not be induced 1 week, and 3 and 9 months later. Radiofrequency ablation is feasible for multiple, haemodynamically unstable ventricular tachycardias in repaired tetralogy of Fallot.

Risk factors and multiple failures in posterior resin-bonded bridges in a 5-year multi-practice clinical trial.

OBJECTIVES: A randomized controlled clinical trial was undertaken, to study the influence of some patient- and operator-dependent variables on the survival of posterior resin-bonded bridges (PRBBs) and to assess the survival of replacement' PRBBs. This report contains some of the results of the 5-year analysis. METHODS: Survival was defined at three levels: (1) complete survival (without any debonding), (2) functional survival (i.e. survival after one loss of retention) and (3) replacement survival (survival of 'replacement' PRBBs, inserted after rebonded bridges suffered a second dislodgement). Potential risk factors were analysed with Cox's proportional hazards model and differences were tested for significance with the Breslow test. Observed effects are expressed as conditional-relative-risk (CRR). Survival of 'replacement' PRBBs was assessed with the Kaplan-Meier method. RESULTS: Factors showing significant influences on complete survival were: 'location' (highest risk for mandibular PRBBs: CRR = 2.2), 'aetiology' (higher risk in treatment of aplasia: CRR = 2.9), and 'time of existence' (open spaces existing less than 2 years before insertion of PRBB: CRR: 2.0). The factor 'large open spaces in the mandible' was a risk for both complete and functional survival (CCR values 3.1 and 3.5, respectively). The survival of mandibular and maxillary 'replacement' PRBBs after 5 years was 19 +/- 7% and 31 +/- 18%, respectively. CONCLUSIONS: Risk factors for PRBBs were: 'location', 'aetiology', 'time of existence', 'isolation method' and 'large open spaces in the mandible'. Mandibular 'replacement' PRBBs showed such an unacceptably low survival rate that fabrication is not recommended.

In vitro milling accuracy and fit of 'natural inlays'.

OBJECTIVE: This study aimed to investigate the milling behaviour of natural inlays (NI) dental restorations constructed from sound extracted teeth. This was done by comparing the milling accuracy and fit of NI to those of industrial porcelain inlays (PI), milled in the same way. METHODS: A calibration pro-inlay was used to mill three NI and three PI. These were cemented in six acrylic cavities reproduced from the calibration mould, using composite luting cement. No etching and bonding were done. After storage for 24 h in water at room temperature the specimens were sliced buccolingually in a standardised way. For each specimen, two sections were photographed under a light-microscope, resulting in enlarged pictures of the sections. An acetate matrix with the measurement points was placed over each picture in a standardised way. The interfaces between inlays and moulds were measured at 13 fixed points per section using computerised image analysis software. The mean vertical- and floor-interfaces were calculated for each picture, and the overall means were found for each group. Confidence intervals were used for comparison of the differences. The profiles of the milled materials were examined using scanning electron microscopy. RESULTS: There were no differences between NI and PI in the mean interfaces (NI, 102 +/- 8 micrometers; PI, 107 +/- 8 micrometers). Electron microscopy revealed no apparent differences in the profiles of the milled surfaces. CONCLUSION: These findings indicate that the milling accuracy and the fit of natural inlays and milled porcelain inlays are comparable.

Guidelines for organisation and management of external quality assessment using proficiency testing. Expert Panel on Cytometry of the International Council for Standardization in Haematology.

This document is intended to assist towards the WHO objective that external quality assessment (EQA) schemes be established at national and/or regional levels world-wide. Quality assurance is defined as all steps taken by the director of a laboratory to ensure reliability of laboratory results and to increase accuracy, reproducibility and between-laboratory comparability. This includes the use of internal quality control procedures and participation in external quality assessment. Internal quality control provides the means for evaluation of analytic test results at the time of testing in order to decide whether they are reliable enough to be released to the requesting clinicians. EQA, on the other hand, refers to a system of retrospective and objective comparison of results from different laboratories by means of proficiency testing (PT) organised by an external agency. The main purpose is to establish between-laboratory and between-method (including between-instrument) comparability, and agreement with a reference standard where one exists. Internal quality control and EQA complement each other and must never be considered as alternatives.

A five-year multi-practice clinical study on posterior resin-bonded bridges.

Previous clinical observations have revealed that resin-bonded bridges for posterior tooth replacements are less retentive than anterior resin-bonded bridges. Improved bonding procedures and preparation designs, however, may have a positive effect on the functional durability of these restorations. The present study reports the final analysis of a randomized controlled clinical trial in which different designs of posterior resin-bonded bridges were evaluated for a period of at least 5 years. The operational hypothesis was that the bonding system and the preparation design used in posterior resin-bonded bridges have an influence on the survival and clinical functioning of these restorations. Survival in this study was defined at two levels: (1) 'complete' survival (survival without any debonding), and (2) 'functional' survival (survival including loss of retention on one occasion and successful rebonding of the original RBB without further debonding). With regard to 'complete' survival, no significant differences were found between the bonding systems used for adherence of the restorations to abutment teeth (etching/Clearfil F2, sandblasting/Panavia EX, and silica-coating/Microfill Pontic C). The variable 'preparation form' (conventional preparation form vs. modified preparation form) for complete survival was statistically in favor of the modified preparation form (62% vs. 46%), but did not influence the functional survival. With regard to 'functional' survival, the combination of silica coating and Microfill Pontic C was more retentive than the other bonding systems (90% survival vs. 72% and 75%, p < 0.01). Factor location was found to be highly significant for both survival levels [Cox's PH model, p = 0.0002 (Cox, 1972)]: The five-year 'complete' survival rates were 65% for maxillary restorations and 40% for mandibular restorations, while the five-year 'functional' survival rates were 89% and 68%, respectively. It is concluded that preparation of grooves in abutment teeth for posterior resin-bonded bridges is beneficial to their chance of survival. Resin-bonded bridges placed in the maxilla have a better prognosis than those made in the mandible. The bonding systems used in this study appear to have no influence on the chance of failure. In rebonded posterior resin-bonded bridges, the bonding system silica-coating/Microfill Pontic C was more retentive than the other systems tested.

Effect of composite basing on the resistance to bulk fracture of industrial porcelain inlays.

OBJECTIVES: Bases are used in restorative dentistry for several reasons (i.e. isolation, elimination of undercuts, etc). Glass ionomers are the standard materials used as bases for porcelain inlays, despite the disadvantages of their mechanical properties. An alternative basing material is composite: a generous layer of posterior composite is cured and shaped in the cavity before an impression is taken. The composite basing technique has several clinical advantages. The aim of this study was to investigate the effect of the thickness of a composite base on the bulk fracture resistance of industrial porcelain, and to describe the procedure. METHODS: Fifteen porcelain (P) and 15 composite (C) bars, 1-, 2-, and 3-mm thick were joined to form 15 C/P bars, all 4-mm thick. Three groups were created: C 1 mm/P 3 mm (group 1), C 2 mm/P 2 mm (group 2), and C 3 mm/P 1 mm (group 3). The pairs were joined using Twinlook cement, subjected to a three-point bending test and loaded to fracture. The beam theory was used to support and explain the results. RESULTS: The fracture load means were: group 1, 197.7 +/- 18.7 N; group 2, 234.3 +/- 63.3 N, group 3, 336.3 +/- 31.3 N. Group 3 was significantly stronger than group 1 (P = 0.01) and group 2 (P = 0.03). Groups 1 and 2 were not statistically different. CONCLUSION: Composite basing is a tissue conserving method which may significantly increase the resistance to bulk fracture of adhesive porcelain inlays.

Management of the child with Wolff-Parkinson-White syndrome and supraventricular tachycardia: model for cost effectiveness.

In the next decade, "better" management will be defined by cost effectiveness including morbidity, mortality, and cost. We used a cost-effectiveness model for children with Wolff-Parkinson-White syndrome (WPW) and supraventricular tachycardia (SVT) comparing medical, surgical, and catheter ablative treatment between age 5 years (estimated average age at first recurrence after infancy) and age 21. Charges were quantitated from actual hospital bills; mortality was estimated from the literature; morbidity was assessed by estimating the number of hours in SVT, hours in clinic, hours in routine hospital bed, and hours in hospital intensive care; and the hours were then multiplied by a severity factor, normalized to 1.0 for 1 hour of SVT (0.5 for 1 hour in clinic, 0.75 for routine hospital, and 2.0 for intensive care). Overall charges (5 to 21 years old) for catheter ablation ($17,236) were 39% of surgical management and 57% of medical management; estimated mortality for catheter ablation (5 to 21 years old including failures that reverted to medical management) was 0.15%, which was 10% of medical management and 28% of surgical management; morbidity for catheter ablation was 27.6 units, which was 32% of medical management and 36% of surgical management. Sensitivity analysis demonstrated that the catheter ablation strategy remained preferable throughout the range of plausible values of cost, mortality, and morbidity (including a repeat procedure for initial failures). Therefore, catheter ablation has lower cost, mortality, and morbidity than either medical management or surgery and is the treatment of choice for the child 5 years of age or older with WPW and SVT. This type of analysis can be used for other forms of chronic disease in children.

Effect of repair strategy on hospital cost for infants with tetralogy of Fallot.

OBJECTIVE: This study compares the total hospital cost (HC) for one-stage versus "two-stage" repair of tetralogy of Fallot (TOF) in infants younger than 1 year of age. SUMMARY BACKGROUND DATA: Total (one-stage) correction of TOF is now being performed with excellent results in infancy. Alternatively, a two-stage approach, with palliation of infants in the first year of life, followed by complete repair at a later time can be used. In some institutions, the two-stage approach is standard practice for infants younger than 1 year of age or is used selectively in patients with an anomalous coronary artery across the right ventricular outflow tract (RVOT), "small pulmonary arteries," multiple congenital anomalies, critical illnesses (CI), which increase the risk of bypass (e.g., sepsis or DIC), or severe hypercyanotic spells (HS) at the time of presentation. The cost implications of these two approaches are unknown. METHODS: The authors reviewed 22 patients younger than 1 year of age who underwent repair of TOF at their institution between 1993 and 1995. Eighteen patients had one-stage (1 degree) repair (mean age, 3.4 +/- 3.1 months; range, 3 days-9 months) and 4 patients were treated by a staged approach with initial palliation (1.6 +/- 0.4 month; range, 1.5-2 months) followed by later repair (14.75 +/- 1.5 months; range, 13-16 months). The reasons for palliation were severe HS at time of presentation (two patients), anomalous coronary artery (one patient) and CI (one patient). In the 18 patients undergoing 1 degree repair, 3 (16.6%) presented with HS, 6 (33.3%) had a transanular repair, and 6 (33.3%) were able to be repaired through an entirely transatrial approach (youngest patient, 1.5 months). The HC (1996 dollars) and hospital length of stay (LOS; days) were evaluated for all patients. The HCs were calculated using transition I, which is a cost accounting system used by our medical center since July 1992. Transition I provides complete data on all direct and indirect hospital-based, nonprofessional costs. RESULTS: There was no mortality in either group. The group undergoing 1 degree repair had an average LOS of 14.5 +/- 11.2 days compared to an average LOS for palliation of 14 +/- 6.4 days. When the palliated group returned for complete repair, the average LOS was 28.8 +/- 25 days, yielding a total LOS for the two-stage strategy of 43 +/- 30.8 days (p = 0.003 compared to 1 degree repair). The HC for 1 degree repair was $32,541 +/- $15,968 compared to $25,737 +/- $1900 for palliation (p = not significant compared to 1 degree repair) and $54,058 +/- $39,395 for subsequent complete repair (p = not significant compared to 1 degree repair) (total two-stage repair HC = $79,795 +/- $40,625; p = 0.001 compared to 1 degree repair). The LOS and HC for the two-stage group combine a total of palliation plus later repair and, as such, reflect two separate hospitalizations and convalescent periods. To eliminate cost outliers, a best-case analysis was performed by eliminating 50% of patients from each group. Using this analysis, the two-stage approach resulted in an average (total) LOS of 16.5 +/- 2.1 days compared to 8.5 +/- 1.4 days for the 1 degree group. Total cost for the two-stage strategy in this best-case group was $44,660 +/- $3645 compared to $22,360 +/- $3331 for 1 degree repair (p = 0.00001). CONCLUSIONS: The data from this review show that palliation alone generates HC similar to that from 1 degree infant repair of TOF, and total combined HC and LOS for palliation plus eventual repair of TOF (two-stage approach) are significantly higher than from 1 degree repair. Furthermore, these data do not include additional costs for care delivered between palliation and repair (e.g., outpatient visits, cardiac catheterization, serial echocardiography). Although there may be occasions when a strategy using initial palliation followed by later repair may seem prudent, the cost is clearly higher and use of health care resources greater.

Long-term survival data from a clinical trial on resin-bonded bridges.

OBJECTIVES: A clinical trial, involving 203 resin-bonded bridges (RBBs) was undertaken to investigate the influence of retainer-type and luting material on the survival of these restorations. METHODS: For this evaluation, 157 patients were available (14% of the original sample was lost to follow-up or excluded from the study following the stopping criteria). Fifty per cent of the patients were questioned concerning the fate of the RBBs and 59% of questioned patients were examined clinically. The patients that were seen for examination were representatives of the experimental groups. The findings from the clinical examination were compared with the data obtained from the questionnaire. Missing data were censored at the date of the last available information. Kaplan-Meier estimates were calculated to assess the survivals at the endpoints and compared using Cox's proportional hazards procedure. RESULTS: A significant difference was found between perforated (P-type) and etched (E-type) RBBs (P = 0.05) for original bonded restorations but not when rebonded RBBs were taken into account. The results of the survival analysis were: anterior P-type, 49 +/- 7% after 10.5 years: anterior E-type, 57 +/- 7% after 10.5 years; posterior P-type, 18 +/- 11% after 6.8 years; posterior E-type, 37 +/- 13% after 10.2 years. Survivals of RBBs that were rebonded once during the evaluation period were 62 +/- 9% (11.0 years) for anterior RBBs and 51 +/- 11% (10.2 years) for posterior RBBs. CONCLUSIONS: The factor location (anterior versus posterior) was as in previous analyses, highly significant. Differences in survival between cementation materials were not significant.