RESUMO
The study revealed high levels of antibodies class A and G to benzopyrene and antibodies class G to estradiol and progesterone in women with pathology of fetus development. The most informative indicators of high risk of development of reproductive pathology are established The recommendations concerning the application of antibodies to benzopyrene, estradiol and progesterone in diagnostics of inherent malformations of fetus are provided.
Assuntos
Anticorpos , Benzo(a)pireno , Estradiol/imunologia , Doenças Fetais , Imunoglobulina A , Imunoglobulina G , Progesterona/imunologia , Adulto , Anticorpos/sangue , Anticorpos/imunologia , Feminino , Doenças Fetais/sangue , Doenças Fetais/diagnóstico , Doenças Fetais/imunologia , Feto/anormalidades , Humanos , Imunoglobulina A/sangue , Imunoglobulina A/imunologia , Imunoglobulina G/sangue , Imunoglobulina G/imunologia , GravidezRESUMO
A study was made of cytotoxic activity of blood serum from 118 patients with borderline neuropsychic disorders (neurotic depression, neurosis, psychopathy, pathologic development of the personality on the basis of organic injury to the brain). Material of 114 mentally and somatically healthy donors served as control. Balb mouse thymocytes and organ culture of the rat brain were employed as test objects. ++Anti-thymus activity (ATA) was measured according to the cytotoxic index, whereas neurotoxic activity (NTA) by inhibition of 3H-cholesterol incorporation. The patients and donors groups differed by distribution of persons with high and low values of NTA and ATA. However, according to the mean level of blood serum cytotoxic activity such a difference was revealed only in respect to NTA. The determined parameters are related in a different way to the patient's age and similarly to the disease standing. The intensity of ATA and NTA was different in different nosological subgroups. An interrelationship was established between the clinical and biological dynamics, supporting a possibility of the use of the given tests as predictors of the therapeutic efficacy and the depth of homeostasis derangement.
Assuntos
Lesões Encefálicas/psicologia , Citotoxicidade Imunológica/fisiologia , Depressão/imunologia , Transtornos Neurocognitivos/imunologia , Transtornos da Personalidade/imunologia , Adulto , Lesões Encefálicas/complicações , Lesões Encefálicas/imunologia , Testes Imunológicos de Citotoxicidade/métodos , Depressão/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Neurocognitivos/etiologia , Transtornos da Personalidade/etiologiaRESUMO
The action of blood serum obtained from 38 schizophrenic patients and 28 control subjects was studied on new cells: Chinese hamster kidney, diploid human cells and glial cultures of immature ependymoblastoma of type 5 mice (IE-5) and neurinoma of rat trigeminal ganglion. Sera of schizophrenic patients--especially of those with a continuous course and disease standing over 5 years and with a recurrent course and disease standing less than 5 years--were found to be significantly more toxic. In the culture of IU-5, sera from schizophrenic patients of a younger age (the mean age 27 years) exerted the most pronounced cytolytic action. Toxic activity of the serum of schizophrenic patients persisted for 14 days at +4 degrees C and 60 days at -30 degrees C but was reduced following thermal treatment (+56 degrees C, 30 min).