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1.
J Artif Organs ; 10(4): 240-4, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18071856

RESUMO

We developed a new coating material (Toyobo-National Cardiovascular Center coating) for medical devices that delivers high antithrombogenicity and long-term durability. We applied this coating to an extracorporeal membrane oxygenation (ECMO) system, including the circuit tube, cannulae, a seal-less centrifugal pump, and a diffusion membrane oxygenator, to realize prolonged cardiopulmonary support with trivial anticoagulant infusion. The oxygenator consisted of a hollow-fiber membrane made of polymethylpentene, which allows the transfer of gas by diffusion through the membrane. The centrifugal pump was free of seals and had a pivot bearing. We performed a venoarterial bypass in a goat using this ECMO system, and the system was driven for 151 days with trivial anticoagulant infusion. Plasma leakage from the oxygenator did not occur and sufficient gas-exchange performance was well maintained. In the oxygenator, thrombus formation was present around the top and the distributor of the inlet portion and was very slight in the outlet portion. In the centrifugal blood pump, there was some wear in the female pivot region and quite small amounts of thrombus formation on the edge of the shroud; the pivot wear seemed to be the cause of the hemolysis observed after 20 weeks of perfusion and which resulted in the termination of the perfusion. However, no significant amounts of thrombus were observed in other parts of the system. This ECMO system showed potential for long-term cardiopulmonary support with minimal use of systemic anticoagulants.


Assuntos
Anticoagulantes/administração & dosagem , Materiais Revestidos Biocompatíveis , Oxigenação por Membrana Extracorpórea/instrumentação , Heparina/administração & dosagem , Perfusão/instrumentação , Animais , Centrifugação , Modelos Animais de Doenças , Desenho de Equipamento , Cabras , Fatores de Tempo
2.
Artif Organs ; 26(6): 548-51, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12072113

RESUMO

We developed an extracorporeal membrane oxygenation (ECMO) system with high antithrombogenicity and durability characteristics for prolonged continuous cardiopulmonary support. The oxygenator consists of a special hollow-fiber-type polyolefin gas-exchange membrane, which has an ultrathin dense layer in contact with the blood, in order to prevent plasma leakage during protracted use (Platinum Cube NCVC). The centrifugal pump (RotaFlow) is free of seals. The entire blood-contacting surface of the system is coated with a newly developed heparin material (Toyobo-NCVC coating). We performed a venoarterial bypass in a goat, and the ECMO system was driven for 34 days without systemic anticoagulants. Plasma leakage from the oxygenator did not occur, and sufficient gas exchange performance was maintained. Thrombus formation was hardly observed in the ECMO system except in the casing margins of the oxygenator. This ECMO system showed potential for long-term cardiopulmonary support with minimal or no use of systemic anticoagulants.


Assuntos
Anticoagulantes/uso terapêutico , Oxigenação por Membrana Extracorpórea/instrumentação , Parada Cardíaca/terapia , Perfusão/instrumentação , Insuficiência Respiratória/terapia , Animais , Modelos Animais de Doenças , Desenho de Equipamento , Cabras , Fatores de Tempo
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