RESUMO
Background: Leukemia is a group of cancers that usually begin in the bone marrow and results in a large number of abnormal white blood cells. Chronic Lymphocytic Leukemia is the most prevalent leukemia in Western countries, with an estimated incidence rate of less than 1 to 5.5 per 100 000 people, and average age at diagnosis of 64 to 72 years. It is more common in men among Chronic Lymphocytic Leukemia patients in Ethiopia's hospitals at Felege Hiwot Referal Hospital. Methods: A retrospective cohort research design was employed to acquire critical information from patients' medical records in order to achieve the study's purpose. The study comprised the medical records of 312 Chronic Lymphocytic Leukemia who were followed from January 1, 2018 to December 31, 2020. A Cox proportional hazard model was used to determine the risk factors for time to death in Chronic Lymphocytic Leukemia patients. Results: Accordingly the Cox proportional hazard model, age (Hazard Ratio = 11.36; P < .001), sex of male (Hazard Ratio = 1.04; P = .004), married status (Hazard Ratio = 0.03; P = .003), medium stages of Chronic Lymphocytic Leukemia (Hazard Ratio = 1.29; P = .024), high stages of Chronic Lymphocytic Leukemia (Hazard Ratio = 1.99; P < .001), presence of anemia (Hazard Ratio =0.09; P = .005), platelets (Hazard Ratio = 2.11; P = .007), hemoglobin (Hazard Ratio = 0.02; P < .001), lymphocytes (Hazard Ratio = 0.29; P = .006), red blood cell (Hazard Ratio = 0.02; P < .001), which patients with Chronic Lymphocytic Leukemia had a significant relationship with time to death. Conclusions: Age, sex, Chronic Lymphocytic Leukemia stage, anemia, platelets, hemoglobin, lymphocytes, and red blood cells were all statistically significant determinants in the time to death of Chronic Lymphocytic Leukemia patients, according to the data. As a result, healthcare providers should pay particular attention to and emphasize the identified characteristics, as well as provide frequent counseling on how to enhance the health of Chronic Lymphocytic Leukemia patients.
RESUMO
BACKGROUND: Adoption of organic fertilization is low among farmers in rural areas of Ethiopia, affecting yields and general food security in the region. This study aimed to identify the determinants of the utilization of organic fertilizers among smallholder farmers in the South Gondar Zone, Amhara National Regional State (ANRS), Northwest Ethiopia. METHODS: A community-based cross-sectional study was used among smallholder farmers in the South Gondar Zone, ANRS, Northwest Ethiopia. Primary data were collected from 420 sample respondents using multistage sampling with a combination of both simple random and cluster sampling techniques. The binary logistic regression model was used to assess the use of organic fertilizers among smallholder farmers in the South Gondar Zone. The results are presented as adjusted odds ratios (AOR) together with their corresponding 95% confidence intervals. RESULTS: head of household age (AOR = 1.099, 95% CI 1.018-1.187), married marital status (AOR = 10.506, 95% CI 1.355-81.427), literate head of household (AOR = 3.323, 95% CI 1.571-7.029), number of laborers (AOR = 1.442, 95% CI 1.060-1.962), farming experience (AOR = 1.132, 95% CI 1.041-1.232), farm size (AOR = 1.063, 95% CI 1.008-1.121), and number of livestock (AOR = 1.368, 95% CI 1.115-1.677) were positively associated with the utilization of organic fertilizer while single marital status (AOR = 0.062, 95% CI 0.004-0.851), cost of laborer (AOR = 0.965, 95% CI 0.951-0.978), household income (AOR = 0.880, 95% CI 0.824-0.939), medium soil fertility (AOR = 0.039, 95% CI 0.007-0.229), fertile soil (AOR = 0.020, 95% CI 0.003-0.120), and home to farm distance (AOR = 0.219, 95% CI 0.067-0.717) were negatively associated with the utilization of organic fertilizer. CONCLUSIONS: This finding showed that multiple variables have an effect to determining the use of organic fertilizer by smallholder farmers. Therefore, the finding is important to adopt programs to encourage the use of organic fertilizer, implement policies in an attempt to adapt the use of organic fertilizer among the South Gondar Zone, and critically consider these factors. Furthermore, extension workers should focus on raising awareness about the importance of organic fertilizers to encourage or expand their use among smallholder farmers.
RESUMO
BACKGROUND: Leukemia is a type of cancers that start in the bone marrow and produce a serious number of abnormal white blood cells. Bleeding and bruising problems, fatigue, fever, and an increased risk of infection are among symptoms of the disease. The main objective of this study is to identify the determinant of the progression rate of white blood cells among patients with chronic lymphocytic leukemia at Felege Hiwot Referral Hospital (FHRH), Bahir Dar, Ethiopia. METHODS: A retrospective study design was conducted on 312 patients with chronic lymphocytic leukemia at FHRH, Bahir Dar, Ethiopia under treatment from 1 January 2017 to 31 December 2019. A linear mixed-effects model was considered for the progression of the white blood cell data. RESULTS: The estimated coefficient of the fixed effect intercept was 84.68, indicating that the average white blood cell (WBC) count of the patients was 84.68 at baseline time by excluding all covariates in the model (P-value <.001). Male sex (ß = 2.92, 95% confidence interval [CI] 0.58, 0.5.25), age (ß = .17, 95% CI 0.08, 0.28), widowed/divorced marital status (ß = 3.30, 95% CI 0.03, 6.57), medium chronic lymphocytic leukemia (CLL) stage (ß = -4.34, 95% CI -6.57, -2.68), high CLL stage (ß = -2.76, 95% CI -4.86, -0.67), hemoglobin (ß = .15, 95% CI 0.07, 0.22), platelet (ß = .09, 95% CI 0.02, 0.17), lymphocytes (ß = .16, 95% CI 0.03, 0.29), red blood cell (RBC) (ß = .17, 95% CI 0.09, 0.25), and follow-up time (ß = .27, 95% CI 0.19, 0.36) were significantly associated with the average WBC count of chronic lymphocytic leukemia patients. CONCLUSIONS: The finding showed that age, sex, lymphocytic, stage of chronic lymphocytic leukemia, marital status, platelet, hemoglobin, RBC, and follow-up time were significantly associated with the average WBC count of chronic lymphocytic leukemia patients. Therefore, health care providers should give due attention and prioritize those identified factors and give frequent counseling about improving the health of chronic lymphocytic leukemia patients.
