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1.
J Craniofac Surg ; 25(6): 1998-2001, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25377986

RESUMO

AIM: The aims of this study were to compare radiofrequency tissue reduction (RFTR) and electrocautery (EC) techniques by assessing preoperatively and 8 weeks postoperatively the visual analog scale (VAS), inspiratory peak flowmetry (IPF), and magnetic resonance imaging (MRI) volume measurement of the inferior turbinate and to see whether EC still stands as a valid treatment of inferior turbinate hypertrophy. METHODS: A total of 36 patients were included in the study. An equal number of patients were chosen randomly from 2 groups. Inferior turbinate volumes measured by MRI, IPF, the VAS, and the Sinonasal Outcome Test-20 were used to determine the efficacy of treatment and to compare the 2 groups. RESULTS: Postoperative IPF increase, VAS score decrease, and Sinonasal Outcome Test-20 score decrease were statistically more significant in the EC group, compared with the RFTR group. Although statistically not significant, postoperative inferior turbinate MRI volume decrease was more evident in the EC group when compared with the RFTR group. CONCLUSIONS: Both RFTR and EC techniques could be used as an effective treatment of choice for inferior turbinate hypertrophy, and EC technique is superior to RFTR technique to achieve high efficiency.


Assuntos
Ablação por Cateter/métodos , Eletrocoagulação/métodos , Obstrução Nasal/cirurgia , Conchas Nasais/cirurgia , Adulto , Feminino , Humanos , Hipertrofia/cirurgia , Capacidade Inspiratória/fisiologia , Imageamento por Ressonância Magnética , Masculino , Obstrução Nasal/etiologia , Obstrução Nasal/fisiopatologia , Medição da Dor , Estudos Prospectivos , Resultado do Tratamento , Conchas Nasais/patologia
2.
Am J Otolaryngol ; 35(6): 791-5, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25148712

RESUMO

OBJECTIVE: We investigated the relationship between facial canal dehiscence and intraoperative middle ear and mastoid findings in patients operated on for cholesteatoma. METHODS: We examined retrospectively 334 patients who had been operated on for cholesteatoma in Izmir Katip Celebi University, Ataturk Research and Training Hospital, ENT Clinic, between April 1997 and April 2010. The patients were examined for facial canal dehiscence according to age, gender, side of the ear, surgery type, first or revision surgery, localization of the facial canal dehiscence, spread of the cholesteatoma, with the presence of lateral semi-circular canal (LSCC) fistula and any defect in the ossicle chain, and destruction in the posterior wall of the external auditory canal(EAC). RESULTS: Of the patients, 23.6% had facial canal dehiscence and detected most commonly in the right ear 28.9% and tympanic segment, 83.5%. Facial canal dehiscence was found to be 24.2-fold more common in patients with LSCC fistula and 4.1-fold more common in patients with destruction in the posterior wall of the (EAC). In patients located cholesteatoma in tympanic cavity+antrum and the tympanic cavity+all mastoid cells and with incus and stapes defect, increased incidence of dehiscence. Age, first or revision operation and canal wall down tympanoplasty (CWDT) or canal wall up tympanoplasty (CWUT) did not affect the incidence of dehiscence. CONCLUSIONS: That the likelihood of facial canal dehiscence occurrence is increased in patients with LSSC fistulas, destruction in the posterior wall of the EAC, or a stapes defect is important information for surgeons.


Assuntos
Colesteatoma da Orelha Média/epidemiologia , Traumatismos do Nervo Facial/patologia , Otite Média/epidemiologia , Adolescente , Adulto , Idoso , Criança , Colesteatoma da Orelha Média/cirurgia , Doença Crônica , Traumatismos do Nervo Facial/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Otite Média/cirurgia , Estudos Retrospectivos , Canais Semicirculares/patologia , Adulto Jovem
3.
J Craniofac Surg ; 25(4): 1305-8, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25006913

RESUMO

OBJECTIVE: To present the results of the traumatic intratemporal facial nerve injury that have undergone facial nerve decompression by using middle cranial fossa (MCF) approach. STUDY DESIGN: A retrospective study SETTING: Tertiary referral center PATIENTS AND METHODS: In this study, 13 patients who developed facial paralysis due to temporal bone trauma and undergone decompression by using MCF approach in Department of Otorhinolaryngology of Izmir Katip Celebi University Research and Training Hospital between January 1993 and December 2012 were presented retrospectively. Patients were assessed in terms of side, etiology, fracture type, House-Brackmann (HB) grade, electroneuronography (ENOG), electromyography (EMG), hearing loss, operation time, and the region of the injury. RESULTS: The fracture was at the right side in 7 (53.8%) and at the left side in 6 patients (46.1%). The type of temporal bone fracture was longitudinal in 6 (46.1%), transverse in 2 (15.3%), and mixed in 5 patients (38.4%). Total axonal degeneration in EMG and ENOG were seen in all patients, who were HB grade 6 at preoperative assessment. Mean operation time was 30 days. The lesion in all patients was at the region of geniculate ganglion. There was conductive hearing loss in 7 patients (53.8%), sensorineural in 4 (30.7%), and mixed in 1 patient (7.6%); hearing was normal in 1 patient (7.6%). Seven patients (53.8%) improved to HB grade 2. CONCLUSION: In the light of the information obtained from HRCT, ENOG, and EMG, we believe that better results can be achieved with facial nerve decompression that is performed before 1 month, and geniculate ganglion region may be better controlled by MCF approach.


Assuntos
Descompressão Cirúrgica/métodos , Traumatismos do Nervo Facial/cirurgia , Paralisia Facial/cirurgia , Adolescente , Adulto , Criança , Fossa Craniana Média/cirurgia , Craniotomia/métodos , Intervenção Médica Precoce , Feminino , Gânglio Geniculado/lesões , Gânglio Geniculado/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fraturas Cranianas/complicações , Osso Temporal/lesões , Adulto Jovem
4.
J Craniofac Surg ; 25(4): 1515-8, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24905944

RESUMO

The aim of our study was to determine the effectiveness of intratympanic α-lipoic acid injection as an otoprotective agent against cisplatin-induced ototoxicity in guinea pigs. Twenty-four adult male albino guinea pigs with normal hearing were divided into 4 groups. The guinea pigs received intraperitoneal cisplatin in group 1, intraperitoneal cisplatin and intratympanic α-lipoic acid in group 2, intratympanic α-lipoic acid in group 3, as well as intraperitoneal cisplatin and intratympanic saline in group 4. Distortion-product otoacoustic emission measurements were obtained for both ears at the following time points: before administration (baseline recording) and on day 3 (72 h later). In group 1 (cisplatin), significant deterioration was observed at all frequencies on day 3 (P < 0.05). In group 2 (cisplatin + α-lipoic acid), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P > 0.05). In group 3 (α-lipoic acid), no significant difference was observed between baseline and day 3 (P > 0.05). In group 4 (cisplatin + saline), deterioration was observed at all frequencies on day 3; however, this deterioration did not reach a statistical significance (P > 0.05). Cisplatin-induced hearing loss in the guinea pigs may be limited to some extent by the concomitant use of α-lipoic acid. Dose-dependent changes in the possible effects of α-lipoic acid need further investigation. Future morphologic studies may contribute to expose clearly the protective effect of α-lipoic acid.


Assuntos
Antineoplásicos/toxicidade , Antioxidantes/uso terapêutico , Cisplatino/toxicidade , Cóclea/efeitos dos fármacos , Substâncias Protetoras/uso terapêutico , Ácido Tióctico/uso terapêutico , Vestíbulo do Labirinto/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Orelha Média , Cobaias , Perda Auditiva/induzido quimicamente , Injeções , Injeções Intraperitoneais , Masculino , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Fatores de Tempo
5.
Int J Pediatr Otorhinolaryngol ; 78(7): 1019-25, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24794623

RESUMO

OBJECTIVES: This study investigated the effects of ascorbic acid and N-acetyl cysteine (NAC) antioxidants on the development of myringosclerosis (MS) in an experimental model. METHODS: Myringotomies were performed in the ears of 15 guinea pigs, and Spongostan pieces were placed on the perforated regions of the tympanic membrane. The subjects were divided randomly into three groups and treated with three different solutions on the Spongostan-group 1: (control, 0.9% saline), group 2 (ascorbic acid), and group 3 (NAC). On day 15 after treatment, specimens from the tympanic membranes were obtained and examined via light microscopy. Sclerosis and inflammation scores and the tympanic membrane thicknesses were evaluated. Immunohistochemical methods were used to evaluate the expression of VEGF, TGF-ß, iNOS, and IL1-ß in all groups. RESULTS: Lower sclerosis and inflammation scores and reduced tympanic membrane thicknesses were observed in groups treated with NAC or ascorbic acid compared with the control group. Immunohistochemical studies revealed significantly less expression of VEGF, TGF-ß, and iNOS in groups 2 and 3 compared with group 1. Additionally, IL1-ß expression was significantly less in group 3 than in group 1. Compared with group 1, group 2 animals exhibited reduced inflammation in the lamina propria, fewer active fibroblasts, less leukocyte infiltration, and decreased thickness of the vessels; group 3 animals exhibited decreased numbers of active fibroblasts and collagen fibers in the lamina propria. CONCLUSIONS: Inflammation scores, cellular infiltration, and expression of VEGF, TGF-ß, and iNOS were reduced by ascorbic acid and/or NAC treatments, thereby decreasing MS development. Decreased expression of IL1-ß was observed only in animals treated with NAC.


Assuntos
Acetilcisteína/farmacologia , Ácido Ascórbico/farmacologia , Miringoesclerose/prevenção & controle , Membrana Timpânica/metabolismo , Membrana Timpânica/patologia , Animais , Antioxidantes/farmacologia , Modelos Animais de Doenças , Feminino , Espuma de Fibrina , Fibroblastos/metabolismo , Sequestradores de Radicais Livres/farmacologia , Cobaias , Hemostáticos , Imuno-Histoquímica , Inflamação/patologia , Leucócitos/metabolismo , Microscopia , Mucosa/patologia , Miringoesclerose/patologia , Óxido Nítrico Sintase/metabolismo , Distribuição Aleatória , Fator de Crescimento Transformador beta/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismo
6.
Eur Arch Otorhinolaryngol ; 271(2): 281-5, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23632875

RESUMO

Endoscopic sinus surgery is a widely used technique in otolaryngologic practice. To avoid complications, the locations of important anatomical structures, such as the anterior ethmoid artery (AEA), should be determined preoperatively. We want to evaluate the effect of ethmoid cavity pneumatization on the location of the AEA and to determine consistent landmark(s) for locating the AEA. 524 consecutive patients undergoing sinus CT scans between February and October 2012 were reviewed retrospectively. After the exclusion criteria were applied, 150 CT scans (300 sides) were selected for the study. A statistically significant positive correlation was found between ethmoid pneumatization and the distance of the AEA to the attachment of the inferior turbinate to the lateral nasal wall (Spearman's rho = 0.305; p < 0.001). Likewise, a statistically significant positive correlation was found between ethmoid pneumatization and the distance between the AEA and the frontonasal junction (Spearman's rho = 0.219; p < 0.001). We found that the artery was located mostly between the second and third lamellae [n 211 (71 %) cases]. There was no statistically significant correlation between ethmoid pneumatization and AEA location in terms of the lamellae. Increased ethmoid volume increases the distance of the AEA from the frontonasal junction and the lateral attachment of the inferior turbinate. However, increased pneumatization of the ethmoid cavity did not affect AEA localization in terms of the lamellae. Based on our findings, we suggest that using the lamellae to locate the AEA is reliable.


Assuntos
Pontos de Referência Anatômicos/diagnóstico por imagem , Seio Etmoidal/diagnóstico por imagem , Artéria Oftálmica/diagnóstico por imagem , Adolescente , Adulto , Idoso , Seio Etmoidal/irrigação sanguínea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Seios Paranasais/irrigação sanguínea , Seios Paranasais/diagnóstico por imagem , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Adulto Jovem
7.
Turk Patoloji Derg ; 30(1): 73-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24101352

RESUMO

Giant cell tumor of soft parts is a rare tumor that is clinically and histologically similar to giant cell tumor of the bone. We present a 53-year-old female with a giant cell tumor of low malignant potential arising from the neck. The clinicopathological features and the importance of immunohistochemistry in the differential diagnosis with other giant cell rich tumors was discussed.


Assuntos
Tumores de Células Gigantes/patologia , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Tecidos Moles/patologia , Biomarcadores Tumorais/análise , Biópsia , Diagnóstico Diferencial , Feminino , Tumores de Células Gigantes/química , Tumores de Células Gigantes/cirurgia , Neoplasias de Cabeça e Pescoço/química , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/cirurgia
8.
Eur Arch Otorhinolaryngol ; 271(4): 743-7, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23999594

RESUMO

The objective of the study was to determine the inter-rater variability in assessment of laryngeal findings and whether diagnosing laryngopharyngeal reflux based on the laryngeal findings and history alone without considering allergic rhinitis leads to the overdiagnosis and overtreatment of laryngopharyngeal reflux. Patients with positive and negative skin prick tests were recruited from an allergy clinic in a tertiary teaching university hospital. All subjects completed the Reflux Symptom Index (RSI) and underwent laryngeal examinations by three physicians blinded to the skin prick test results and the Reflux Finding Score (RFS) was determined. RFS >7 or RSI >13 was considered reflux positive. Fleiss' kappa (κ) was used to measure inter-rater agreement. The inter-rater agreement was low for pseudosulcus vocalis (κ = 0.078), ventricular obliteration (κ = 0.206), diffuse laryngeal edema (κ = 0.204), and posterior laryngeal hypertrophy (κ = 0.27), intermediate for laryngeal erythema/hyperemia (κ = 0.42) and vocal fold edema (κ = 0.42), and high for thick endolaryngeal mucus (κ = 0.61). Although the frequency of allergy was high, there was no significant difference between allergy-positive and laryngopharyngeal reflux-positive patients. On logistic regression analysis, thick endolaryngeal mucus was a significant predictor of allergy (p = 0.012, odds ratio 0.264, 95 % confidence interval 0.093-0.74). The laryngeal examination for reflux is subject to marked inter-rater variability and allergic laryngitis was not misdiagnosed as laryngopharyngeal reflux. The presence of thick endolaryngeal mucus should alert physicians to the possibility of allergic rhinitis/laryngitis.


Assuntos
Refluxo Laringofaríngeo/diagnóstico , Laringoscopia , Rinite Alérgica Perene/diagnóstico , Prega Vocal/patologia , Adulto , Estudos de Coortes , Diagnóstico Diferencial , Feminino , Humanos , Edema Laríngeo/diagnóstico , Edema Laríngeo/patologia , Laringite/diagnóstico , Laringite/patologia , Refluxo Laringofaríngeo/patologia , Laringe/patologia , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Estudos Prospectivos , Rinite Alérgica , Rinite Alérgica Perene/patologia , Adulto Jovem
9.
Acta Otolaryngol ; 133(11): 1201-6, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24125191

RESUMO

CONCLUSIONS: Vocal and ventricular fold lateralization using crossing sutures with the thyroplasty window technique is an effective and durable procedure for the management of patients with bilateral vocal fold immobility. OBJECTIVES: To review the long-term results of bilateral vocal fold immobility in 26 patients treated with vocal and ventricular fold lateralization using crossing sutures with the thyroplasty window technique over a 6-year period. METHODS: This retrospective study examined patients with a minimum follow-up of 1 year. The main outcome measures used were the modified Medical Research Council (MRC) dyspnoea scale and the assessment of voice quality pre- and postoperatively using the Likert method. RESULTS: The mean follow-up period was 23.77 ± 12.01 months. All patients reported marked symptomatic improvement in dyspnoea (p = 0.0001). The voice quality worsened as expected; however, this difference did not reach a significant level (p = 0.642). Transient microaspiration was noted in seven of the patients and resolved in 1 or 2 days. The procedure was performed for the contralateral vocal fold in one case, due to the loss of suture tension. No patient showed aspiration postoperatively or during follow-up. All patients were regularly followed up for the beginning of movement of the lateralized or contralateral vocal folds in our outpatient clinic.


Assuntos
Laringoplastia/métodos , Paralisia das Pregas Vocais/cirurgia , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Técnicas de Sutura , Resultado do Tratamento
10.
J Craniofac Surg ; 24(5): 1716-9, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24036762

RESUMO

OBJECTIVE: This study evaluated the outcome in adult patients with laryngotracheal stenosis (LTS) and assessed the effect of procedures on their quality-of-life scores. METHODS: The study included 15 adult patients with LTS (11 males [73.3%], 4 females [26.7%]; mean age, 32 years [range, 10-52 years]) treated at the Department of Otolaryngology Head and Surgery Clinic, Izmir Atatürk Research Hospital, Turkey, from 1997 to 2008. Success of the surgery is evaluated by decanullation rate, Short form-36 (SF-36), and the Medical Research Council dyspnea scale. RESULTS: The etiology of the LTS was intubation related in 14 cases (93.3%) and idiopathic in 1 case. According to the Myers-Cotton classification, 2 (13%), 8 (54%), and 5 (33%) patients were at stages 2 to 4, respectively. Fourteen patients had a mean follow-up of 57 months (range, 24-256 months). The stenotic segment involved 1 to 3 cm (mean, 1.7 cm) of trachea, and 2 to 5 tracheal rings (mean, 3.1) were resected. Postoperative decannulation was achieved in 13 patients (86.6%). In the short form-36 questionnaire, all of the parameters except for "role-emotional" were found to be significant (P < 0.01). The Medical Research Council dyspnea scale assessment revealed a significant (P < 0.001) decrease postoperatively. CONCLUSIONS: Segmental resection with primary anastomosis is an effective method and can be used as the first option in selected cases of advanced stenosis.


Assuntos
Intubação Intratraqueal/efeitos adversos , Laringoestenose/cirurgia , Estenose Traqueal/cirurgia , Adolescente , Adulto , Criança , Constrição Patológica , Feminino , Humanos , Laringoestenose/etiologia , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Qualidade de Vida , Estenose Traqueal/etiologia , Turquia , Adulto Jovem
11.
Int J Pediatr Otorhinolaryngol ; 77(9): 1465-8, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23899702

RESUMO

OBJECTIVE: To investigate the ototoxic effect of boric acid solution prepared with different degree of alcohol. METHODS: This study was performed on 28 young albino guinea pigs. After the animals divided four groups prior to the application of the solution an auditory brainstem response (ABR) test was applied to the each animal under general anesthesia. Their tympanic membranes perforated and test solutions were administrated to the middle ear through the perforation. On 15th day, ABR measurements were carried out and comparison was made with preadministration values. RESULTS: The degrees of hearing loss occurring as a result of the administration of 4% boric alcohol solutions prepared with 60° and 40° alcohol differed significantly (p < 0.001). CONCLUSION: It was established that 4% boric acid solution prepared with 60 alcohol affected hearing in guinea pigs more negatively and an increase in degree of alcohol also increased the ototoxicity of the boric acid solution.


Assuntos
Ácidos Bóricos/toxicidade , Orelha Média/efeitos dos fármacos , Etanol/toxicidade , Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Perda Auditiva/induzido quimicamente , Animais , Limiar Auditivo/efeitos dos fármacos , Ácidos Bóricos/farmacologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Combinação de Medicamentos , Etanol/farmacologia , Cobaias , Perda Auditiva/diagnóstico , Instilação de Medicamentos , Distribuição Aleatória , Valores de Referência
12.
Kulak Burun Bogaz Ihtis Derg ; 23(1): 15-20, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23521407

RESUMO

OBJECTIVES: This study aims to evaluate the complications of tracheoesophageal puncture (TEP) for voice restoration and speech valves in patients undergoing total laryngectomy. PATIENTS AND METHODS: Between January 2006 and June 2011, 47 male patients (mean age 62.8±1.2 years; range 41 to 80 years) who underwent TEP and speech valve for voice restoration after total laryngectomy were retrospectively analyzed. Secondary TEP was performed and Provox indwelling voice prosthesis were inserted in all patients. Demographic, disease and treatment characteristics of patients were recorded. Complications related to TEP and speech valves, the management of complications and clinical conditions of complete closure of TEP were also recorded. RESULTS: Tracheoesophageal puncture and speech valve related complications were observed in 20 patients. The majority of complications were minor complications including granulation tissue formation (n=2, 4.2%), deglutition of prosthesis (n=6, 12.7%) and TEP enlargement/leakage around prosthesis (n=9, 19.1%). Major complications were observed in three patients. Two of them were life-threatening complications; a mediastinitis (n=1, 3.1%) and paraesophageal abscess (n=1, 3.1%), and both appeared in the first month of the postoperative period. The overall complication rate was 42.6% during mean follow-up of 15.3 months. Tracheoesophageal fistula enlargement (n=9, 19.1%) was the most common minor complication and the most common cause of complete closure of TEP in this study. CONCLUSION: Tracheoesophageal puncture for voice restoration is not an entirely innocent procedure without any complications. Patients should be monitored for TEP-related complications in the early and late postoperative period.


Assuntos
Esôfago/cirurgia , Laringectomia/efeitos adversos , Laringe Artificial/efeitos adversos , Punções/efeitos adversos , Traqueia/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/secundário , Carcinoma de Células Escamosas/cirurgia , Neoplasias de Cabeça e Pescoço/secundário , Humanos , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Voz Esofágica/métodos
13.
Eur Arch Otorhinolaryngol ; 270(2): 469-75, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22456810

RESUMO

Magnetic resonance imaging (MRI) of the internal acoustic canal is the standard diagnostic tool for a wide range of indications in patients. This study aims to investigate the vascular variations and compression of the cranial nerves (CNs) VII and VIII at the cerebellopontine angle in patients with neuro-otologic symptoms using 3D-fast imaging employing steady-state acquisition (FIESTA) MR imaging. One hundred and eighty-seven patients (374 temporal bones) were examined on a 1.5-T MRI. In addition to conventional MR sequences, a 3D-FIESTA MR imaging was acquired. Magnetic resonance images thus obtained were evaluated with special regard to the presence of vascular contact to the CNs VII and VIII, as well as the presence of the vascular variations of the anterior inferior cerebellar artery (AICA) causing the compression of CNs. The Chi-squared test was used for statistical analysis. No statistically significant differences were found between the presence and absence of the AICA loop and/or vascular contact for the clinical symptoms of patients (P > 0.05). The cisternal and canalicular segments of CNs VII and VIII and adjacent vascular variations are well identified using 3D-FIESTA, especially by determining the relationship of the AICA variations between CNs.


Assuntos
Meato Acústico Externo/patologia , Imageamento por Ressonância Magnética , Nervo Facial/patologia , Doenças do Nervo Facial/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Síndromes de Compressão Nervosa/diagnóstico , Osso Temporal/patologia , Nervo Vestibulococlear/patologia , Doenças do Nervo Vestibulococlear/diagnóstico
14.
Kulak Burun Bogaz Ihtis Derg ; 22(6): 348-53, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23176700

RESUMO

Synovial sarcomas (SS) account for 7-8% of soft-tissue cancers and 3-5% of all cases with head and neck involvement. Synovial sarcoma of the infratemporal fossa is very rare In this article, we report the fourth case of SS of infratemporal fossa and the first case with intracranial extension via the foramen ovale. A 31-year-old man admitted with a one-year history of intense pain in his right jaw. On physical examination, there was only hyperesthesia over the right mandible side. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a mass in the infratemporal fossa and intracranial extension from the foramen ovale. The mass was surgically removed en bloc. Postoperative pathological examination reported the mass as a biphasic-type synovial sarcoma. The patient who received postoperative chemoradiotherapy had no recurrent disease for one year. The patient is still being followed in our clinic.


Assuntos
Sarcoma Sinovial/patologia , Neoplasias Cranianas/patologia , Osso Esfenoide , Osso Temporal , Adulto , Quimiorradioterapia Adjuvante , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Masculino , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/cirurgia , Sarcoma Sinovial/terapia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/cirurgia , Neoplasias Cranianas/terapia , Osso Esfenoide/patologia , Osso Temporal/patologia , Articulação Temporomandibular/patologia , Tomografia Computadorizada por Raios X
15.
Ear Nose Throat J ; 91(9): 383-4, 386, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22996710

RESUMO

We conducted a prospective study to compare the effectiveness of conventional computed tomography (CT) and puffed-cheek CT in detecting the presence and extension of oral cavity malignant tumors. We enrolled 11 patients--5 men and 6 women, aged 32 to 85 years--who had a primary squamous cell carcinoma of the oral cavity. These tumors were located in the floor of the mouth in 4 patients, in the buccal mucosa in 4, in both the buccal mucosa and retromolar trigone in 2, and in the retromolar trigone only in 1. First, conventional contrast-enhanced axial CT was obtained through the oral cavity and neck in each patient. Next, axial imaging was obtained through the oral cavity while patients inflated their cheeks, pursed their lips, and held their breath. We found that the puffed-cheek CTs provided more information regarding the size and extent of the squamous cell carcinomas than did the conventional CTs. For example, in 8 patients, conventional CT could not differentiate the tumor from the normal mucosal surface, but puffed-cheek images clearly showed the surface of the tumor as distinct from the normal mucosa. More disconcerting was the fact that in the other 3 patients, conventional CTs were evaluated as normal, even though puffed-cheek imaging clearly showed the mass in each case. We conclude that puffed-cheek CT is superior to conventional CT for evaluating the mucosal surfaces of the oral cavity. It provides a clearer and more detailed picture with no downside.


Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Insuflação/métodos , Neoplasias Bucais/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
16.
Otolaryngol Head Neck Surg ; 147(6): 1093-8, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22886078

RESUMO

OBJECTIVE: The aim of this study was to analyze the functional and oncologic results of supracricoid partial laryngectomy. STUDY DESIGN: Case series with chart review. SETTING: Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. SUBJECT AND METHODS: The medical records of 56 patients, who underwent supracricoid partial laryngectomy between March 2002 and December 2010, were reviewed in this study. Forty-three patients underwent supracricoid partial laryngectomy with cricohyoidopexy, and 13 patients underwent cricohyoidoepiglottopexy. The overall and disease-specific survival, local control rates, and the mean time of decannulation and nasogastric tube removal were evaluated. Association of type of surgery with the functional and oncologic outcomes was evaluated and statistically compared. RESULTS: The median follow-up period was 58 months. The 1-, 3-, and 5-year overall survival rates were 100%, 96.4%, and 82.1%, respectively. The 1-, 3-, and 5-year local control rates were 100%, 96.1%, and 92.5%, respectively. Type of surgery did not show any significant difference in survival and local control rates (P = .546, P = .455). The mean (SD) decannulation and nasogastric feeding tube removal time was 11.43 (2.03) and 16.79 (3.51) days, respectively. The mean time of decannulation and nasogastric tube removal was significantly longer in patients who underwent cricohyoidopexy when compared with those who underwent cricohyoidoepiglottopexy (P = .002, P = .000). CONCLUSION: Although delaying deglutition functions could be termed a disadvantage of supracricoid laryngectomy, especially with cricohyoidopexy, supracricoid laryngectomy has reliable oncologic and functional results for locally advanced laryngeal cancers while maintaining laryngeal functions.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Laríngeas/cirurgia , Laringectomia/métodos , Adulto , Idoso , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Cartilagem Cricoide/cirurgia , Deglutição/fisiologia , Remoção de Dispositivo , Nutrição Enteral/instrumentação , Epiglote/cirurgia , Feminino , Seguimentos , Humanos , Osso Hioide/cirurgia , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/patologia , Laringectomia/mortalidade , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Taxa de Sobrevida , Cartilagem Tireóidea/cirurgia , Fatores de Tempo , Resultado do Tratamento , Turquia
17.
Int J Pediatr Otorhinolaryngol ; 76(9): 1343-6, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22763210

RESUMO

OBJECTIVE: To evaluate the effectiveness of micronized flavonoid fraction in preventing cisplatin ototoxicity in a guinea pig model. METHODS: This study was conducted on 23 guinea pigs in the Animal Laboratory of Izmir Atatürk Training and Research Hospital. Animals were divided into three groups: Group 1 consisted of eight animals receiving cisplatin only; Group 2 contained eight animals receiving cisplatin+micronized flavonoid fraction; and Group 3 contained seven animals that received micronized flavonoid fraction only. Their cochlear reserve was evaluated by measuring the distortion product otoacoustic emission on days 0 and 7. RESULTS: In Groups 1 and 2, the intragroup signal-noise ratios were statistically different at all frequencies tested (based on negative ranks, p<0.05). In Group 3, the intragroup signal-noise ratios did not differ significantly at the frequencies tested (p>0.05). Comparison of the three groups showed statistically significant differences among the groups (p<0.05). The post hoc Bonferroni correction showed statistically significant differences among all three groups (p<0.016). The median signal-noise ratio of the three groups tended to increase (z-value was positive for all the frequencies tested; p<0.01). CONCLUSION: Micronized flavonoid fraction (Daflon) is effective against cisplatin-induced ototoxicity in guinea pigs.


Assuntos
Antineoplásicos/efeitos adversos , Cisplatino/efeitos adversos , Cóclea/efeitos dos fármacos , Diosmina/uso terapêutico , Otopatias/prevenção & controle , Animais , Diosmina/farmacologia , Modelos Animais de Doenças , Feminino , Flavonoides , Cobaias , Emissões Otoacústicas Espontâneas
18.
Otolaryngol Head Neck Surg ; 147(5): 907-11, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22753616

RESUMO

OBJECTIVE: To describe 2 subapproaches of the middle fossa approach: the transillumination method and transection of lines using the foramen spinosum, greater superficial petrosal nerve, and trigeminal impression to locate the malleus head for safe identification and decompression of the geniculate ganglion and facial nerve. STUDY DESIGN: Cadaver study. SETTING: A tertiary university hospital anatomy laboratory. SUBJECTS AND METHODS: The present study was conducted using 7 formalin-fixed cadaver heads (14 sides). A 0° endoscope was introduced into the external ear canal toward the posterosuperior quadrant of the tympanic membrane, after which transillumination was used to locate the malleus head. The brightest point indicated the convergence of the greater superficial petrosal nerve and a line drawn along the superior semicircular canal. An additional line was drawn parallel to the petrous ridge from the foramen spinosum and along the pathway of the greater superficial petrosal nerve. A third line connected the trigeminal impression to the zygomatic root. The area posterior to the intersection of these 2 lines separately with the third line was considered the zone of location of the malleus head. Among 17 patients undergoing surgery for facial paralysis between 1993 and 2011, transillumination was used in 6 patients to identify the malleus head to locate the geniculate ganglion. RESULTS: These techniques were proven to be reliable in locating the malleus head to find the geniculate ganglion in 14 dissected cadaveric temporal bones. CONCLUSION: Two methods of locating the malleus head for facial decompression were defined.


Assuntos
Fossa Craniana Média/anatomia & histologia , Descompressão Cirúrgica/métodos , Paralisia Facial/cirurgia , Cadáver , Paralisia Facial/etiologia , Fraturas Ósseas/complicações , Humanos , Osso Temporal/lesões
19.
Turk Patoloji Derg ; 28(2): 178-80, 2012.
Artigo em Turco | MEDLINE | ID: mdl-22627640

RESUMO

Clear cell variant of mucoepidermoid carcinoma of the salivary glands is rare. A 55-year-old male patient with recently growing left parotid mass underwent superficial parotidectomy. Although the dominant component of the tumor was composed of clear cells, mucin containing cells were also present. Histochemically, alcian blue stain supported intracellular mucin positivity. Immunohistochemically, p63 was positive. Based on the morphological, histochemical and immunohistochemical findings, the case was diagnosed as mucoepidermoid carcinoma, clear cell variant.


Assuntos
Carcinoma Mucoepidermoide/patologia , Neoplasias Parotídeas/patologia , Biomarcadores Tumorais/análise , Biópsia , Carcinoma Mucoepidermoide/química , Carcinoma Mucoepidermoide/cirurgia , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Mucinas/análise , Neoplasias Parotídeas/química , Neoplasias Parotídeas/cirurgia , Coloração e Rotulagem , Fatores de Transcrição/análise , Proteínas Supressoras de Tumor/análise
20.
Otolaryngol Head Neck Surg ; 146(3): 390-4, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22194242

RESUMO

OBJECTIVE: Head and neck squamous cell carcinomas readily metastasize to adjacent cervical lymph nodes. This is seen frequently in laryngeal squamous cell carcinoma (LSCC), and neck dissection may be performed in addition to excision of the primary lesion. The aim of this study was to define the frequency of level IIb metastasis to the lymph nodes in patients who underwent selective neck dissection because of LSCC. STUDY DESIGN AND SETTING: Cross-sectional study with planned data collection in a tertiary referral hospital. SUBJECTS AND METHODS: Eighty-one patients diagnosed with LSCC were accepted into the study. One hundred forty-eight neck dissection specimens were examined histopathologically, and those with level IIb metastasis were identified. The frequency of level IIb metastasis was evaluated in accordance with the primary tumor site, clinical N stage, central tumor presence, and T stage. RESULTS: Forty-seven of 81 patients were clinically N-, and 34 patients were clinically N+. Level IIb metastasis was seen in 5 (6%) of 81 patients, representing 5 of 148 neck dissection specimens. Two of these 5 patients were clinically N+ (6%), and 3 were clinically N- (6%). The relationship between level IIb metastasis and clinical N stage was not statistically significant (P ≥ .05). Likewise, no statistically significant relationships between the other parameters and level IIb involvement were found. CONCLUSION: Level IIb nodal involvement is very rare in LSCC. Therefore, the area can generally be preserved in elective neck dissection to lessen morbidity and, specifically, to avoid damaging the function of the spinal accessory nerve.


Assuntos
Carcinoma de Células Escamosas/secundário , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/cirurgia , Metástase Linfática/patologia , Esvaziamento Cervical/métodos , Adulto , Idoso , Terapia Combinada , Estudos Transversais , Intervalo Livre de Doença , Feminino , Seguimentos , Secções Congeladas , Humanos , Neoplasias Laríngeas/mortalidade , Laringectomia/métodos , Laringectomia/mortalidade , Excisão de Linfonodo/métodos , Excisão de Linfonodo/mortalidade , Masculino , Pessoa de Meia-Idade , Esvaziamento Cervical/mortalidade , Esvaziamento Cervical/estatística & dados numéricos , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/patologia , Estudos Prospectivos , Medição de Risco , Análise de Sobrevida , Resultado do Tratamento
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