Absolute Pose Estimation of Central Cameras Using Planar Regions.

A novel method is proposed for the absolute pose estimation of a central 2D camera with respect to 3D depth data without the use of any dedicated calibration pattern or explicit point correspondences. The proposed method has no specific assumption about the data source: plain depth information is expected from the 3D sensing device and a central camera is used to capture the 2D images. Both the perspective and omnidirectional central cameras are handled within a single generic camera model. Pose estimation is formulated as a 2D-3D nonlinear shape registration task which is solved without point correspondences or complex similarity metrics. It relies on a set of corresponding planar regions, and the pose parameters are obtained by solving an overdetermined system of nonlinear equations. The efficiency and robustness of the proposed method were confirmed on both large scale synthetic data and on real data acquired from various types of sensors.

Accurate Morphology Preserving Segmentation of Overlapping Cells based on Active Contours.

The identification of fluorescently stained cell nuclei is the basis of cell detection, segmentation, and feature extraction in high content microscopy experiments. The nuclear morphology of single cells is also one of the essential indicators of phenotypic variation. However, the cells used in experiments can lose their contact inhibition, and can therefore pile up on top of each other, making the detection of single cells extremely challenging using current segmentation methods. The model we present here can detect cell nuclei and their morphology even in high-confluency cell cultures with many overlapping cell nuclei. We combine the "gas of near circles" active contour model, which favors circular shapes but allows slight variations around them, with a new data model. This captures a common property of many microscopic imaging techniques: the intensities from superposed nuclei are additive, so that two overlapping nuclei, for example, have a total intensity that is approximately double the intensity of a single nucleus. We demonstrate the power of our method on microscopic images of cells, comparing the results with those obtained from a widely used approach, and with manual image segmentations by experts.

Realigning 2D and 3D Object Fragments without Correspondences.

This paper addresses the problem of simultaneous estimation of different linear deformations, resulting in a global non-linear transformation, between an original object and its broken fragments. A general framework is proposed without using correspondences, where the solution of a polynomial system of equations directly provides the parameters of the alignment. We quantitatively evaluate the proposed algorithm on a large synthetic dataset containing 2D and 3D images, where linear (rigid-body and affine) transformations are considered. We also conduct an exhaustive analysis of the robustness against segmentation errors and the numerical stability of the proposed method. Moreover, we present experiments on 2D real images as well as on volumetric medical images.

A spline-based non-linear diffeomorphism for multimodal prostate registration.

This paper presents a novel method for non-rigid registration of transrectal ultrasound and magnetic resonance prostate images based on a non-linear regularized framework of point correspondences obtained from a statistical measure of shape-contexts. The segmented prostate shapes are represented by shape-contexts and the Bhattacharyya distance between the shape representations is used to find the point correspondences between the 2D fixed and moving images. The registration method involves parametric estimation of the non-linear diffeomorphism between the multimodal images and has its basis in solving a set of non-linear equations of thin-plate splines. The solution is obtained as the least-squares solution of an over-determined system of non-linear equations constructed by integrating a set of non-linear functions over the fixed and moving images. However, this may not result in clinically acceptable transformations of the anatomical targets. Therefore, the regularized bending energy of the thin-plate splines along with the localization error of established correspondences should be included in the system of equations. The registration accuracies of the proposed method are evaluated in 20 pairs of prostate mid-gland ultrasound and magnetic resonance images. The results obtained in terms of Dice similarity coefficient show an average of 0.980±0.004, average 95% Hausdorff distance of 1.63±0.48 mm and mean target registration and target localization errors of 1.60±1.17 mm and 0.15±0.12 mm respectively.

Nonlinear shape registration without correspondences.

In this paper, we propose a novel framework to estimate the parameters of a diffeomorphism that aligns a known shape and its distorted observation. Classical registration methods first establish correspondences between the shapes and then compute the transformation parameters from these landmarks. Herein, we trace back the problem to the solution of a system of nonlinear equations which directly gives the parameters of the aligning transformation. The proposed method provides a generic framework to recover any diffeomorphic deformation without established correspondences. It is easy to implement, not sensitive to the strength of the deformation, and robust against segmentation errors. The method has been applied to several commonly used transformation models. The performance of the proposed framework has been demonstrated on large synthetic data sets as well as in the context of various applications.

Detection of object motion regions in aerial image pairs with a multilayer markovian model.

We propose a new Bayesian method for detecting the regions of object displacements in aerial image pairs. We use a robust but coarse 2-D image registration algorithm. Our main challenge is to eliminate the registration errors from the extracted change map. We introduce a three-layer Markov random field (L(3)MRF) model which integrates information from two different features, and ensures connected homogenous regions in the segmented images. Validation is given on real aerial photos.