Self-driven configurational dynamics in frustrated spring-mass systems.

Various physical systems relax mechanical frustration through configurational rearrangements. We examine such rearrangements via Hamiltonian dynamics of simple internally stressed harmonic four-mass systems. We demonstrate theoretically and numerically how mechanical frustration controls the underlying potential energy landscape. Then, we examine the harmonic four-mass systems' Hamiltonian dynamics and relate the onset of chaotic motion to self-driven rearrangements. We show such configurational dynamics may occur without strong precursors, rendering such dynamics seemingly spontaneous.

Computational wave-based photoacoustic imaging through an unknown thick aberrating layer.

We introduce a physics-based computational reconstruction framework for non-invasive photoacoustic tomography through a thick aberrating layer. Our wave-based approach leverages an analytic formulation of diffraction to beamform a photoacoustic image, when the aberrating layer profile is known. When the profile of the aberrating layer is unknown, the same analytical formulation serves as the basis for an automatic-differentiation regularized optimization algorithm that simultaneously reconstructs both the profile of the aberrating layer and the optically absorbing targets. Results from numerical studies and proof-of-concept experiments show promise for fast beamforming that takes into account diffraction effects occurring in the propagation through thick, highly-aberrating layers.

Image scanning lensless fiber-bundle endomicroscopy.

Fiber-based confocal endomicroscopy has shown great promise for minimally-invasive deep-tissue imaging. Despite its advantages, confocal fiber-bundle endoscopy inherently suffers from undersampling due to the spacing between fiber cores, and low collection efficiency when the target is not in proximity to the distal fiber facet. Here, we demonstrate an adaptation of image-scanning microscopy (ISM) to lensless fiber bundle endoscopy, doubling the spatial sampling frequency and significantly improving collection efficiency. Our approach only requires replacing the confocal detector with a camera. It improves the spatial resolution for targets placed at a distance from the fiber tip, and addresses the fundamental challenge of aliasing/pixelization artifacts.

Towards passive non-line-of-sight acoustic localization around corners using uncontrolled random noise sources.

Non-line-of-sight (NLoS) imaging is an important challenge in many fields ranging from autonomous vehicles and smart cities to defense applications. Several recent works in optics and acoustics tackle the challenge of imaging targets hidden from view (e.g. placed around a corner) by measuring time-of-flight information using active SONAR/LiDAR techniques, effectively mapping the Green functions (impulse responses) from several controlled sources to an array of detectors. Here, leveraging passive correlations-based imaging techniques (also termed 'acoustic daylight imaging'), we study the possibility of acoustic NLoS target localization around a corner without the use of controlled active sources. We demonstrate localization and tracking of a human subject hidden around a corner in a reverberating room using Green functions retrieved from correlations of broadband uncontrolled noise sources recorded by multiple detectors. Our results demonstrate that for NLoS localization controlled active sources can be replaced by passive detectors as long as a sufficiently broadband noise is present in the scene.

A flexible two-photon fiberscope for fast activity imaging and precise optogenetic photostimulation of neurons in freely moving mice.

We developed a flexible two-photon microendoscope (2P-FENDO) capable of all-optical brain investigation at near cellular resolution in freely moving mice. The system performs fast two-photon (2P) functional imaging and 2P holographic photostimulation of single and multiple cells using axially confined extended spots. Proof-of-principle experiments were performed in freely moving mice co-expressing jGCaMP7s and the opsin ChRmine in the visual or barrel cortex. On a field of view of 250 µm in diameter, we demonstrated functional imaging at a frame rate of up to 50 Hz and precise photostimulation of selected groups of cells. With the capability to simultaneously image and control defined neuronal networks in freely moving animals, 2P-FENDO will enable a precise investigation of neuronal functions in the brain during naturalistic behaviors.

Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography.

Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, current micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use of bulky optical elements such as lenses and scanners at the distal end, increasing the footprint and tissue-damage. Great efforts have been invested in developing approaches that avoid distal bulky optical elements. However, the fundamental barrier of dynamic optical wavefront-distortions in propagation through flexible fibers limits current approaches to nearly-static or non-flexible fibers. Here, we present an approach that allows holographic, bend-insensitive, coherence-gated, micro-endoscopic imaging using commercially available multi-core fibers (MCFs). We achieve this by adding a partially-reflecting mirror to the distal fiber-tip, allowing to perform low-coherence full-field phase-shifting holography. We demonstrate widefield diffraction-limited reflection imaging of amplitude and phase targets through dynamically bent fibers at video-rate. Our approach holds potential for label-free investigations of dynamic samples.

Massively degenerate coherent perfect absorber for arbitrary wavefronts.

One of the key insights of non-Hermitian photonics is that well-established concepts such as the laser can be operated in reverse to realize a coherent perfect absorber (CPA). Although conceptually appealing, such CPAs are limited so far to a single, judiciously shaped wavefront or mode. Here, we demonstrate how this limitation can be overcome by time-reversing a degenerate cavity laser based on a unique cavity that self-images any incident light field onto itself. Placing a weak, critically coupled absorber into this cavity, any incoming wavefront, even a complex and dynamically varying speckle pattern, is absorbed with close to perfect efficiency in a massively parallel interference process. These characteristics open up interesting new possibilities for applications in light harvesting, energy delivery, light control, and imaging.

Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues.

Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather than label-free imaging mode, making them unsuitable for general medical diagnosis. Herein, we report a fully flexible ultrathin fibre endoscope taking 3D holographic images of unstained tissues with 0.85-µm spatial resolution. Using a bare fibre bundle as thin as 200-µm diameter, we design a lensless Fourier holographic imaging configuration to selectively detect weak reflections from biological tissues, a critical step for label-free endoscopic reflectance imaging. A unique algorithm is developed for calibration-free holographic image reconstruction, allowing us to image through a narrow and curved passage regardless of fibre bending. We demonstrate endoscopic reflectance imaging of unstained rat intestine tissues that are completely invisible to conventional endoscopes. The proposed endoscope will expedite a more accurate and earlier diagnosis than before with minimal complications.

New constraints on axion-like dark matter using a Floquet quantum detector.

Dark matter is one of the greatest mysteries in physics. It interacts via gravity and composes most of our universe, but its elementary composition is unknown. We search for nongravitational interactions of axion-like dark matter with atomic spins using a precision quantum detector. The detector is composed of spin-polarized xenon gas that can coherently interact with a background dark matter field as it traverses through the galactic dark matter halo. Conducting a 5-month-long search, we report on the first results of the Noble and Alkali Spin Detectors for Ultralight Coherent darK matter (NASDUCK) collaboration. We limit ALP-neutron interactions in the mass range of 4 × 10-15 to 4 × 10-12 eV/c2 and improve upon previous terrestrial bounds by up to 1000-fold for masses above 4 × 10-13 eV/c2. We also set bounds on pseudoscalar dark matter models with quadratic coupling.

Everything Seems So Illogical: Constructing Missingness Between Life and Death in Israel.

This paper discusses the case of missing persons in Israel, to show how the category of "missingness" is constructed by the people who have been left behind, and how this may threaten the life-death dichotomy assumption. The field of missing persons in Israel is characterized not only by high uncertainty, but also by the absence of relevant cultural scripts. Based on a narrative ethnography of missingness in Israel, I claim that a new and subversive social category of "missingness" can be constructed following the absence of cultural scripts. The left-behinds fluctuate not only between different assumptions about the missing person's fate; they also fluctuate between acceptance of the life-death dichotomy, thus yearning for a solution to a temporary in-between state, and blurring this dichotomy, and thus constructing "missingness" as a new stable and subversive ontological category. Under this category, new rites of passage are also negotiated and constructed.

Guidestar-free image-guided wavefront shaping.

Optical imaging through scattering media is a fundamental challenge in many applications. Recently, breakthroughs such as imaging through biological tissues and looking around corners have been obtained via wavefront-shaping approaches. However, these require an implanted guidestar for determining the wavefront correction, controlled coherent illumination, and most often raster scanning of the shaped focus. Alternative novel computational approaches that exploit speckle correlations avoid guidestars and wavefront control but are limited to small two-dimensional objects contained within the "memory-effect" correlation range. Here, we present a new concept, image-guided wavefront shaping, allowing widefield noninvasive, guidestar-free, incoherent imaging through highly scattering layers, without illumination control. The wavefront correction is found even for objects that are larger than the memory-effect range, by blindly optimizing image quality metrics. We demonstrate imaging of extended objects through highly scattering layers and multicore fibers, paving the way for noninvasive imaging in various applications, from microscopy to endoscopy.

Three-dimensional broadband light beam manipulation in forward scattering samples.

Focusing light into highly disordered biological tissue is a major challenge in optical microscopy and biomedical imaging due to scattering. However, correlations in the scattering matrix, known as "memory effects", can be used to improve imaging capabilities. Here we discuss theoretically and numerically the possibility to achieve three-dimensional ultrashort laser focusing and scanning inside forward scattering media, beyond the scattering mean free path, by simultaneously taking advantage of the angular and the chromato-axial memory effects. The numerical model is presented in details, is validated within the state of the art theoretical and experimental framework and is finally used to propose a scheme for focusing ultra-short laser pulses in depth through forward scattering media.

100,000 frames-per-second compressive imaging with a conventional rolling-shutter camera by random point-spread-function engineering.

We demonstrate an approach that allows taking videos at very high frame-rates of over 100,000 frames per second by exploiting the fast sampling rate of the standard rolling-shutter readout mechanism, common to most conventional sensors, and a compressive-sampling acquisition scheme. Our approach is directly applied to a conventional imaging system by the simple addition of a diffuser to the pupil plane that randomly encodes the entire field-of-view to each camera row, while maintaining diffraction-limited resolution. A short video is reconstructed from a single camera frame via a compressed-sensing reconstruction algorithm, exploiting the inherent sparsity of the imaged scene.

Using fiber-bending-generated speckles for improved working distance and background rejection in lensless micro-endoscopy.

Lensless flexible fiber-bundle-based endoscopes allow imaging at depths beyond the reach of conventional microscopes with a minimal footprint. These multicore fibers provide a simple solution for wide-field fluorescent imaging when the target is adjacent to the fiber facet. However, they suffer from a very limited working distance and out-of-focus background. Here, we carefully study the dynamic speckle illumination patterns generated by bending a commercial fiber bundle and show that they can be exploited to allow extended working distance and background rejection, using a super-resolution fluctuations imaging analysis of multiple frames, without the addition of any optical elements.

Regular regimes of the harmonic three-mass system.

The symmetric harmonic three-mass system with finite rest lengths, despite its apparent simplicity, displays a wide array of interesting dynamics for different energy values. At low energy the system shows regular behavior that produces a deformation-induced rotation with a constant averaged angular velocity. As the energy is increased this behavior makes way to a chaotic regime with rotational behavior statistically resembling Lévy walks and random walks. At high enough energies, where the rest lengths become negligible, the chaotic signature vanishes and the system returns to regularity, with a single dominant frequency. The transition to and from chaos, as well as the anomalous power-law statistics measured for the angular displacement of the harmonic three-mass system are largely governed by the structure of regular solutions of this mixed Hamiltonian system. Thus, a deeper understating of the system's irregular behavior requires mapping out its regular solutions. In this work we provide a comprehensive analysis of the system's regular regimes of motion, using perturbative methods to derive analytical expressions of the system as almost-integrable in its low- and high-energy extremes. The compatibility of this description with the full system is shown numerically. In the low-energy regime, the Birkhoff normal form method is utilized to circumvent the low-order 1:1 resonance of the system, and the conditions for Kolmogorov-Arnold-Moser theory are shown to hold. The integrable approximations provide the back-bone structure around which the behavior of the full nonlinear system is organized and provide a pathway to understanding the origin of the power-law statistics measured in the system.

Super-resolution photoacoustic and ultrasound imaging with sparse arrays.

It has previously been demonstrated that model-based reconstruction methods relying on a priori knowledge of the imaging point spread function (PSF) coupled to sparsity priors on the object to image can provide super-resolution in photoacoustic (PA) or in ultrasound (US) imaging. Here, we experimentally show that such reconstruction also leads to super-resolution in both PA and US imaging with arrays having much less elements than used conventionally (sparse arrays). As a proof of concept, we obtained super-resolution PA and US cross-sectional images of microfluidic channels with only 8 elements of a 128-elements linear array using a reconstruction approach based on a linear propagation forward model and assuming sparsity of the imaged structure. Although the microchannels appear indistinguishable in the conventional delay-and-sum images obtained with all the 128 transducer elements, the applied sparsity-constrained model-based reconstruction provides super-resolution with down to only 8 elements. We also report simulation results showing that the minimal number of transducer elements required to obtain a correct reconstruction is fundamentally limited by the signal-to-noise ratio. The proposed method can be straigthforwardly applied to any transducer geometry, including 2D sparse arrays for 3D super-resolution PA and US imaging.

Passive optical time-of-flight for non line-of-sight localization.

Optical imaging through diffusive, visually-opaque barriers and around corners is an important challenge in many fields, ranging from defense to medical applications. Recently, novel techniques that combine time-of-flight (TOF) measurements with computational reconstruction have allowed breakthrough imaging and tracking of objects hidden from view. These light detection and ranging (LiDAR)-based approaches require active short-pulsed illumination and ultrafast time-resolved detection. Here, bringing notions from passive radio detection and ranging (RADAR) and passive geophysical mapping approaches, we present an optical TOF technique that allows passive localization of light sources and reflective objects through diffusive barriers and around corners. Our approach retrieves TOF information from temporal cross-correlations of scattered light, via interferometry, providing temporal resolution that surpasses state-of-the-art ultrafast detectors by three orders of magnitude. While our passive approach is limited by signal-to-noise to relatively sparse scenes, we demonstrate passive localization of multiple white-light sources and reflective objects hidden from view using a simple setup.

Controlling light in complex media beyond the acoustic diffraction-limit using the acousto-optic transmission matrix.

Studying the internal structure of complex samples with light is an important task but a difficult challenge due to light scattering. While the complex optical distortions induced by scattering can be effectively undone if the medium's scattering-matrix is known, this matrix generally cannot be retrieved without the presence of an invasive detector or guide-star at the target points of interest. To overcome this limitation, the current state-of-the-art approaches utilize focused ultrasound for generating acousto-optic guide-stars, in a variety of different techniques. Here, we introduce the acousto-optic transmission matrix (AOTM), which is an ultrasonically-encoded, spatially-resolved, optical scattering-matrix. The AOTM provides both a generalized framework to describe any acousto-optic based technique, and a tool for light control and focusing beyond the acoustic diffraction-limit inside complex samples. We experimentally demonstrate complex light control using the AOTM singular vectors, and utilize the AOTM framework to analyze the resolution limitation of acousto-optic guided focusing approaches.

Self-Driven Fractional Rotational Diffusion of the Harmonic Three-Mass System.

In flat space, changing a system's velocity requires the presence of an external force. However, an isolated nonrigid system can freely change its orientation due to the nonholonomic nature of the angular momentum conservation law. Such nonrigid isolated systems may thus manifest their internal dynamics as rotations. In this work, we show that for such systems chaotic internal dynamics may lead to macroscopic rotational random walk resembling thermally induced motion. We do so by studying the classical harmonic three-mass system in the strongly nonlinear regime, the simplest physical model capable of zero angular momentum rotation as well as chaotic dynamics. At low energies, the dynamics are regular and the system rotates at a constant rate with zero angular momentum. For sufficiently high energies a rotational random walk is observed. For intermediate energies the system performs ballistic bouts of constant rotation rates interrupted by unpredictable orientation reversal events, and the system constitutes a simple physical model for Lévy walks. The orientation reversal statistics in this regime lead to a fractional rotational diffusion that interpolates smoothly between the ballistic and regular diffusive regimes.

(Un) Natural Grief: Novelty, Tradition and Naturalization in Israeli Discourse on Posthumous Reproduction.

This article examines Israeli discourse on posthumous reproduction (PR) and the related cultural construction of "(un)natural" grief. Based mainly on an analysis of in-depth interviews with family members who submitted a request for PR, we examine the regimes of justification used by supporters and opponents of this technology. With both sides using the notion of "nature" to support their claim, the dispute centers on whether PR constructs a new social expression of grief (and hence should be seen as unnatural) or is only a reflection of an age-old grieving process (and is thus natural). We argue that by employing a twofold, novel/traditional justification, PR supporters aim to go one step further, from a symbolic continuity of the dead to a so-called real one. This progression highlights the flexibility of the natural category at the intersection of technology and culture and the abandonment of such binary distinctions as life/death and nature/culture.